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- W2194732252 abstract "UNTIL recently carcinoma of the lung has been considered a relatively infrequent condition. However, recent studies demonstrate that pulmonary malignancy is not only a common occurrence but is one of the most frequent carcinomas of the body. This increase in incidence of bronchogenic malignancy is undoubtedly both apparent and real, as evinced by autopsy series from the German Clinics. Junghanns found an incidence of pulmonary carcinoma of 1.67 per cent of all autopsies performed from 1893 to 1927. The incidence of primary pulmonary carcinoma in all malignancies found at autopsy was 14.27 per cent during the period from 1893 to 1897. Seyfarth found increases in the incidence of pulmonary carcinoma from 5.01 per cent during 1900 to 1906 to 8.75 per cent from 1919 to 1923. During the first half of 1924 there was an incidence of 15.5 per cent. Jaff$eA, of Chicago, believes that pulmonary carcinoma represents 11.47 per cent of all carcinomas, and that pulmonary carcinoma was second in frequency only to carcinoma of the stomach and of the intestine. Frissel and Knox, in a series of 3,659 autopsies, found 588 cases of carcinoma of which 39 were carcinoma of the lung, thus representing 6.6 per cent of the total carcinomas and 1.06 per cent of the total autopsies. D'Aunoy, Pearson, and Halpert reported that of 6,000 necropsies on persons over 1 year of age, performed in the Charity Hospital in New Orleans, primary carcinoma of the lung occurred in 70, or 1.1 per cent, and was almost as frequent as primary carcinoma of the biliary tract or of the pancreas. In 1,244 autopsies performed at the Touro Infirmary in New Orleans there were 259 cases with carcinoma. Twenty-three of the carcinomas originated in the bronchus. The incidence of bronchial carcinoma in the total autopsies was 1.8 per cent, whereas that in all carcinomas was 8.8 per cent (36). It is evident, therefore, that the frequency of pulmonary carcinoma is high. The fact that in Jaff$eA's cases it was second only to carcinoma of the stomach emphasizes the necessity for its clinical consideration.Although it is controversial whether the increase in pulmonary carcinoma in recent years is apparent or real, the German autopsy statistics would indicate that the increase is actual and not only apparent. There are several explanations for the actual increase in the incidence of pulmonary malignancies, most of which have not been satisfactory. A number of theories have been suggested. Winternitz, Wason, and McNamara, because of the presence of metaplasia in the bronchial mucosa of persons dying from influenza, suggested that this change is a precancerous lesion. The inhalation of irritating gases such as war gas or gas originating from the increased use of motor cars has been proposed as an etiological factor. In our opinion the increase in smoking with the universal custom of inhaling is probably a responsible factor, as the inhaled smoke, constantly repeated over a long period of time, undoubtedly is a source of chronic irritation to the bronchial mucosa. In addition to the actual increase in pulmonary malignancy, there is unquestionably a relative increase in those localities where routine postmortem examinations previously have not been made. This is due probably to the fact that the condition has not been suspected in many cases and adequate diagnostic procedures have not been employed. The recent development of thoracic surgery has stimulated interest in intrathoracic lesions. This, with the development of specialized methods of diagnosis, has facilitated the recognition of pulmonary malignancies." @default.
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- W2194732252 title "Primary pulmonary malignancy: treatment by total pneumonectomy; analysis of 79 collected cases and presentation of 7 personal cases." @default.
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