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• W2194865652 startingPage "25" @default.
• W2194865652 abstract "Abstract Obesity is characterized by an increase in fat mass primarily as a result of adipocyte hypertrophy. Diets enriched in omega ( n )‐3 polyunsaturated fatty acids (PUFA) are suggested to reduce obesity, however, the mechanisms are not well understood. We investigated the effect of n ‐3 PUFA on adipocyte hypertrophy and the key genes involved in adipocyte hypertrophy. Female C57BL/6 mice were fed semi‐purified diets (20 % w/w fat) containing high n ‐3 PUFA before mating, during pregnancy, and until weaning. Male and female offspring were continued on high n ‐3 PUFA (10 % w/w), medium n ‐3 PUFA (4 % w/w), or low n ‐3 PUFA (2 % w/w) diet for 16 weeks postweaning. Adipocyte area was quantified using microscopy, and gonadal mRNA expression of acyl CoA:diacylglycerol acyltransferase‐2 (DGAT‐2), fatty acid binding protein‐4 (FABP‐4) and leptin were measured. The high n ‐3 PUFA group showed higher levels of total n ‐3 PUFA in gonadal TAG compared to the medium and low n ‐3 PUFA groups ( P < 0.001). The high n ‐3 PUFA male group had a lower adipocyte area compared to the medium and low n ‐3 PUFA group ( P < 0.001); however, no difference was observed in females. The high n ‐3 PUFA male group showed lower mRNA expression of FABP‐4, DGAT‐2 and leptin compared to the low n ‐3 PUFA group, with no difference in females. Plasma lipid levels were lower in the high n ‐3 PUFA group compared to the other groups. Our findings show for the first time that n ‐3 PUFA prevents adipocyte hypertrophy by downregulating FABP‐4, DGAT‐2 and leptin; the effects are however sex‐specific." @default.
• W2194865652 created "2016-06-24" @default.
• W2194865652 creator A5024635358 @default.
• W2194865652 creator A5025216670 @default.
• W2194865652 date "2015-12-11" @default.
• W2194865652 modified "2023-10-09" @default.
• W2194865652 title "Dietary Omega‐3 Fatty Acids Prevented Adipocyte Hypertrophy by Downregulating <i>DGAT</i>‐<i>2</i> and <i>FABP</i>‐<i>4</i> in a Sex‐Dependent Fashion" @default.
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