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• W2194888552 startingPage "1681" @default.
• W2194888552 abstract "Escherichia coli has three DNA polymerases implicated in the bypass of DNA damage, a process called translesion synthesis (TLS) that alleviates replication stalling. Although these polymerases are specialized for different DNA lesions, it is unclear if they interact differently with the replication machinery. Of the three, DNA polymerase (Pol) II remains the most enigmatic. Here we report a stable ternary complex of Pol II, the replicative polymerase Pol III core complex and the dimeric processivity clamp, β. Single-molecule experiments reveal that the interactions of Pol II and Pol III with β allow for rapid exchange during DNA synthesis. As with another TLS polymerase, Pol IV, increasing concentrations of Pol II displace the Pol III core during DNA synthesis in a minimal reconstitution of primer extension. However, in contrast to Pol IV, Pol II is inefficient at disrupting rolling-circle synthesis by the fully reconstituted Pol III replisome. Together, these data suggest a β-mediated mechanism of exchange between Pol II and Pol III that occurs outside the replication fork." @default.
• W2194888552 created "2016-06-24" @default.
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• W2194888552 date "2015-12-10" @default.
• W2194888552 modified "2023-10-05" @default.
• W2194888552 title "Exchange between<i>Escherichia coli</i>polymerases II and III on a processivity clamp" @default.
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• W2194888552 doi "https://doi.org/10.1093/nar/gkv1375" @default.
• W2194888552 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4770218" @default.
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• W2194888552 hasPublicationYear "2015" @default.
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