FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2194947045> ?p ?o ?g. }

• W2194947045 endingPage "188" @default.
• W2194947045 startingPage "180" @default.
• W2194947045 abstract "A potential role for immune dysfunction in autism spectrum disorders (ASD) has been well established. However, immunological features of Rett syndrome (RTT), a genetic neurodevelopmental disorder closely related to autism, have not been well addressed yet. By using multiplex Luminex technology, a panel of 27 cytokines and chemokines was evaluated in serum from 10 RTT patients with confirmed diagnosis of MECP2 mutation (typical RTT), 12 children affected by classic autistic disorder and 8 control subjects. The cytokine/chemokine gene expression was assessed by real time PCR on mRNA of isolated peripheral blood mononuclear cells (PBMCs). Moreover, ultrastructural analysis of PBMCs was performed using transmission electron microscopy (TEM). Significantly higher serum levels of interleukin-8 (IL-8), IL-9, IL-13 were detected in RTT compared to control subjects, and IL-15 shows a trend toward the upregulation in RTT. In addition, IL-1β and VEGF were the only down-regulated cytokines in autistic patients with respect to RTT. No difference in cytokine/chemokine profile between autistic and control groups was detected. These data were also confirmed by ELISA real time PCR. At the ultrastructural level, the most severe morphological abnormalities were observed in mitochondria of both RTT and autistic PBMCs. In conclusion, our study shows a deregulated cytokine/chemokine profile together with morphologically altered immune cells in RTT. Such abnormalities were not quite as evident in autistic subjects. These findings indicate a possible role of immune dysfunction in RTT making the clinical features of this pathology related also to the immunology aspects, suggesting, therefore, novel possible therapeutic interventions for this disorder." @default.
• W2194947045 created "2016-06-24" @default.
• W2194947045 creator A5003122342 @default.
• W2194947045 creator A5006491765 @default.
• W2194947045 creator A5010261777 @default.
• W2194947045 creator A5029455714 @default.
• W2194947045 creator A5039126618 @default.
• W2194947045 creator A5046340193 @default.
• W2194947045 creator A5065384634 @default.
• W2194947045 creator A5070209640 @default.
• W2194947045 date "2016-01-01" @default.
• W2194947045 modified "2023-09-25" @default.
• W2194947045 title "Cytokines profile and peripheral blood mononuclear cells morphology in Rett and autistic patients" @default.
• W2194947045 cites W1763873242 @default.
• W2194947045 cites W1963952288 @default.
• W2194947045 cites W1966717823 @default.
• W2194947045 cites W1968577394 @default.
• W2194947045 cites W1983444230 @default.
• W2194947045 cites W1987368333 @default.
• W2194947045 cites W1994210488 @default.
• W2194947045 cites W1998619221 @default.
• W2194947045 cites W2001605140 @default.
• W2194947045 cites W2012807815 @default.
• W2194947045 cites W2018685944 @default.
• W2194947045 cites W2020407498 @default.
• W2194947045 cites W2026751327 @default.
• W2194947045 cites W2032817788 @default.
• W2194947045 cites W2035339084 @default.
• W2194947045 cites W2035770994 @default.
• W2194947045 cites W2036075099 @default.
• W2194947045 cites W2044745325 @default.
• W2194947045 cites W2045042214 @default.
• W2194947045 cites W2051460287 @default.
• W2194947045 cites W2055823139 @default.
• W2194947045 cites W2058533604 @default.
• W2194947045 cites W2058783695 @default.
• W2194947045 cites W2075046972 @default.
• W2194947045 cites W2075190567 @default.
• W2194947045 cites W2076155145 @default.
• W2194947045 cites W2077162835 @default.
• W2194947045 cites W2082548421 @default.
• W2194947045 cites W2118742454 @default.
• W2194947045 cites W2119129835 @default.
• W2194947045 cites W2119337283 @default.
• W2194947045 cites W2135882681 @default.
• W2194947045 cites W2141082604 @default.
• W2194947045 cites W2141171636 @default.
• W2194947045 cites W2152423521 @default.
• W2194947045 cites W2154057943 @default.
• W2194947045 cites W2156732833 @default.
• W2194947045 cites W2160533950 @default.
• W2194947045 cites W2163485668 @default.
• W2194947045 cites W2165978081 @default.
• W2194947045 cites W2168058242 @default.
• W2194947045 cites W2169760625 @default.
• W2194947045 cites W2127567778 @default.
• W2194947045 doi "https://doi.org/10.1016/j.cyto.2015.10.002" @default.
• W2194947045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26471937" @default.
• W2194947045 hasPublicationYear "2016" @default.
• W2194947045 type Work @default.
• W2194947045 sameAs 2194947045 @default.
• W2194947045 citedByCount "50" @default.
• W2194947045 countsByYear W21949470452016 @default.
• W2194947045 countsByYear W21949470452017 @default.
• W2194947045 countsByYear W21949470452018 @default.
• W2194947045 countsByYear W21949470452019 @default.
• W2194947045 countsByYear W21949470452020 @default.
• W2194947045 countsByYear W21949470452021 @default.
• W2194947045 countsByYear W21949470452022 @default.
• W2194947045 countsByYear W21949470452023 @default.
• W2194947045 crossrefType "journal-article" @default.
• W2194947045 hasAuthorship W2194947045A5003122342 @default.
• W2194947045 hasAuthorship W2194947045A5006491765 @default.
• W2194947045 hasAuthorship W2194947045A5010261777 @default.
• W2194947045 hasAuthorship W2194947045A5029455714 @default.
• W2194947045 hasAuthorship W2194947045A5039126618 @default.
• W2194947045 hasAuthorship W2194947045A5046340193 @default.
• W2194947045 hasAuthorship W2194947045A5065384634 @default.
• W2194947045 hasAuthorship W2194947045A5070209640 @default.
• W2194947045 hasConcept C104317684 @default.
• W2194947045 hasConcept C118552586 @default.
• W2194947045 hasConcept C127716648 @default.
• W2194947045 hasConcept C13373296 @default.
• W2194947045 hasConcept C137061746 @default.
• W2194947045 hasConcept C202751555 @default.
• W2194947045 hasConcept C203014093 @default.
• W2194947045 hasConcept C205778803 @default.
• W2194947045 hasConcept C2777543196 @default.
• W2194947045 hasConcept C2778690821 @default.
• W2194947045 hasConcept C2778863441 @default.
• W2194947045 hasConcept C2779388368 @default.
• W2194947045 hasConcept C54355233 @default.
• W2194947045 hasConcept C71924100 @default.
• W2194947045 hasConcept C86803240 @default.
• W2194947045 hasConcept C8891405 @default.
• W2194947045 hasConceptScore W2194947045C104317684 @default.
• W2194947045 hasConceptScore W2194947045C118552586 @default.
• W2194947045 hasConceptScore W2194947045C127716648 @default.

• next