Matches in SemOpenAlex for { <https://semopenalex.org/work/W2195011242> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2195011242 endingPage "1256" @default.
- W2195011242 startingPage "1250" @default.
- W2195011242 abstract "Complement anaphylatoxins have been investigated extensively; however, the role of complement anaphylatoxin C4a in hyperoxic lung injury has yet to be investigated. To the best of our knowledge, the present study is the first to demonstrate the role of C4a in hyperoxic lung injury in vitro and in vivo. BALB/c mice were ventilated with 100% oxygen with or without C4a treatment for 36 h. The body weight and the relative lung weight of the mice were determined, along with any morphological changes in the lung. The expression levels of interleukin (IL)-1, IL-6 and tumor necrosis factor-α (TNF-α) were quantified in the lung tissue and bronchoalveolar lavage fluid (BALF) samples by enzyme-linked immunosorbent assay (ELISA) and western blot analysis. The total cell count and the number of macrophages, neutrophils and lymphocytes in the BALF were determined using cytocentrifuge slides and a hemocytometer. Histamine release from total cells in the BALF was also analyzed. The relative mRNA expression levels of CD68, F4/80, CD64, CD19 and CD3 in the murine lung tissue were assessed by reverse transcription-quantitative polymerase chain reaction. The results revealed that hyperoxia induced lung injury and morphological changes, and increased the expression levels of IL-1, IL-6 and TNF-α, histamine release, the number of inflammatory cells, and the expression levels of CD68, F4/80, CD64, CD19 and CD3. The hyperoxia-induced morphological changes and inflammatory reaction were significantly attenuated in mice treated with C4a. Treatment with C4a also attenuated the increase in the total cell count, decreased the number of macrophages in the BALF, and suppressed the elevated mRNA expression levels of CD68 and F4/80 in the lung tissue samples. Conversely, treatment with C4a did not affect the number of neutrophils or lymphocytes in the BALF or the mRNA expression of CD64, CD19 and CD3 in lung tissue. In conclusion, C4a attenuated hyperoxic lung injury via a macrophage-dependent but not a neutrophil/lymphocyte-dependent pathway." @default.
- W2195011242 created "2016-06-24" @default.
- W2195011242 creator A5004907720 @default.
- W2195011242 creator A5037775867 @default.
- W2195011242 creator A5053741998 @default.
- W2195011242 creator A5054029283 @default.
- W2195011242 creator A5069896801 @default.
- W2195011242 date "2015-12-07" @default.
- W2195011242 modified "2023-09-30" @default.
- W2195011242 title "Protective effect of C4a against hyperoxic lung injury via a macrophage-dependent but not a neutrophil/lymphocyte-dependent signaling pathway" @default.
- W2195011242 cites W1527953088 @default.
- W2195011242 cites W1837446566 @default.
- W2195011242 cites W1948268265 @default.
- W2195011242 cites W1969614900 @default.
- W2195011242 cites W1977584500 @default.
- W2195011242 cites W2003481405 @default.
- W2195011242 cites W2010270130 @default.
- W2195011242 cites W2030074507 @default.
- W2195011242 cites W2034441952 @default.
- W2195011242 cites W2041189421 @default.
- W2195011242 cites W2060261829 @default.
- W2195011242 cites W2068549054 @default.
- W2195011242 cites W2077262223 @default.
- W2195011242 cites W2079427425 @default.
- W2195011242 cites W2082005220 @default.
- W2195011242 cites W2086687613 @default.
- W2195011242 cites W2090829322 @default.
- W2195011242 cites W2100837269 @default.
- W2195011242 cites W2127875836 @default.
- W2195011242 cites W2172046528 @default.
- W2195011242 cites W71208058 @default.
- W2195011242 doi "https://doi.org/10.3892/mmr.2015.4651" @default.
- W2195011242 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26648567" @default.
- W2195011242 hasPublicationYear "2015" @default.
- W2195011242 type Work @default.
- W2195011242 sameAs 2195011242 @default.
- W2195011242 citedByCount "3" @default.
- W2195011242 countsByYear W21950112422017 @default.
- W2195011242 countsByYear W21950112422021 @default.
- W2195011242 countsByYear W21950112422023 @default.
- W2195011242 crossrefType "journal-article" @default.
- W2195011242 hasAuthorship W2195011242A5004907720 @default.
- W2195011242 hasAuthorship W2195011242A5037775867 @default.
- W2195011242 hasAuthorship W2195011242A5053741998 @default.
- W2195011242 hasAuthorship W2195011242A5054029283 @default.
- W2195011242 hasAuthorship W2195011242A5069896801 @default.
- W2195011242 hasBestOaLocation W21950112421 @default.
- W2195011242 hasConcept C111684460 @default.
- W2195011242 hasConcept C126322002 @default.
- W2195011242 hasConcept C153911025 @default.
- W2195011242 hasConcept C159654299 @default.
- W2195011242 hasConcept C17991360 @default.
- W2195011242 hasConcept C203014093 @default.
- W2195011242 hasConcept C2777714996 @default.
- W2195011242 hasConcept C2777961210 @default.
- W2195011242 hasConcept C2780672939 @default.
- W2195011242 hasConcept C71924100 @default.
- W2195011242 hasConcept C86803240 @default.
- W2195011242 hasConcept C90582226 @default.
- W2195011242 hasConceptScore W2195011242C111684460 @default.
- W2195011242 hasConceptScore W2195011242C126322002 @default.
- W2195011242 hasConceptScore W2195011242C153911025 @default.
- W2195011242 hasConceptScore W2195011242C159654299 @default.
- W2195011242 hasConceptScore W2195011242C17991360 @default.
- W2195011242 hasConceptScore W2195011242C203014093 @default.
- W2195011242 hasConceptScore W2195011242C2777714996 @default.
- W2195011242 hasConceptScore W2195011242C2777961210 @default.
- W2195011242 hasConceptScore W2195011242C2780672939 @default.
- W2195011242 hasConceptScore W2195011242C71924100 @default.
- W2195011242 hasConceptScore W2195011242C86803240 @default.
- W2195011242 hasConceptScore W2195011242C90582226 @default.
- W2195011242 hasIssue "2" @default.
- W2195011242 hasLocation W21950112421 @default.
- W2195011242 hasLocation W21950112422 @default.
- W2195011242 hasOpenAccess W2195011242 @default.
- W2195011242 hasPrimaryLocation W21950112421 @default.
- W2195011242 hasRelatedWork W1569422489 @default.
- W2195011242 hasRelatedWork W186272449 @default.
- W2195011242 hasRelatedWork W2010848172 @default.
- W2195011242 hasRelatedWork W2063876721 @default.
- W2195011242 hasRelatedWork W2074394995 @default.
- W2195011242 hasRelatedWork W2100686743 @default.
- W2195011242 hasRelatedWork W2162868360 @default.
- W2195011242 hasRelatedWork W2296819479 @default.
- W2195011242 hasRelatedWork W2364686720 @default.
- W2195011242 hasRelatedWork W2377286306 @default.
- W2195011242 hasVolume "13" @default.
- W2195011242 isParatext "false" @default.
- W2195011242 isRetracted "false" @default.
- W2195011242 magId "2195011242" @default.
- W2195011242 workType "article" @default.