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- W2195071417 abstract "Despite extensive research, no therapeutic interventions have been shown to prevent AKI, accelerate recovery of AKI, or reduce progression of AKI to CKD in patients. This failure in translation has led investigators to speculate that the animal models being used do not predict therapeutic responses in humans. Although this issue continues to be debated, an important concern that has not been addressed is whether improvements in preclinical study design can be identified that might also increase the likelihood of translating basic AKI research into clinical practice using the current models. In this review, we have taken an evidence-based approach to identify common weaknesses in study design and reporting in preclinical AKI research that may contribute to the poor translatability of the findings. We focused on use of N-acetylcysteine or sodium bicarbonate for the prevention of contrast-induced AKI and use of erythropoietin for the prevention of AKI, two therapeutic approaches that have been extensively studied in clinical trials. On the basis of our findings, we identified five areas for improvement in preclinical study design and reporting. These suggested and preliminary guidelines may help improve the quality of preclinical research for AKI drug development." @default.
- W2195071417 created "2016-06-24" @default.
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- W2195071417 date "2015-12-01" @default.
- W2195071417 modified "2023-10-12" @default.
- W2195071417 title "Bridging Translation by Improving Preclinical Study Design in AKI" @default.
- W2195071417 cites W11766024 @default.
- W2195071417 cites W1533115818 @default.
- W2195071417 cites W1549329940 @default.
- W2195071417 cites W1790120012 @default.
- W2195071417 cites W1965024037 @default.
- W2195071417 cites W1967014306 @default.
- W2195071417 cites W1970174538 @default.
- W2195071417 cites W1970753596 @default.
- W2195071417 cites W1973190471 @default.
- W2195071417 cites W1974181209 @default.
- W2195071417 cites W1980538933 @default.
- W2195071417 cites W1983640477 @default.
- W2195071417 cites W1987777080 @default.
- W2195071417 cites W1990337194 @default.
- W2195071417 cites W1990817996 @default.
- W2195071417 cites W1991267170 @default.
- W2195071417 cites W1991778938 @default.
- W2195071417 cites W1993209689 @default.
- W2195071417 cites W1993847258 @default.
- W2195071417 cites W1996238457 @default.
- W2195071417 cites W1999938053 @default.
- W2195071417 cites W2003423899 @default.
- W2195071417 cites W2004678839 @default.
- W2195071417 cites W2009324582 @default.
- W2195071417 cites W2016702021 @default.
- W2195071417 cites W2019442978 @default.
- W2195071417 cites W2020689357 @default.
- W2195071417 cites W2021690806 @default.
- W2195071417 cites W2028309540 @default.
- W2195071417 cites W2028758495 @default.
- W2195071417 cites W2031700674 @default.
- W2195071417 cites W2035076162 @default.
- W2195071417 cites W2038997540 @default.
- W2195071417 cites W2041179993 @default.
- W2195071417 cites W2041438931 @default.
- W2195071417 cites W2045804567 @default.
- W2195071417 cites W2047621580 @default.
- W2195071417 cites W2048060485 @default.
- W2195071417 cites W2048373970 @default.
- W2195071417 cites W2049069390 @default.
- W2195071417 cites W2049153360 @default.
- W2195071417 cites W2050034605 @default.
- W2195071417 cites W2051557145 @default.
- W2195071417 cites W2051640837 @default.
- W2195071417 cites W2053043470 @default.
- W2195071417 cites W2055395864 @default.
- W2195071417 cites W2058665168 @default.
- W2195071417 cites W2058982742 @default.
- W2195071417 cites W2064814194 @default.
- W2195071417 cites W2065594595 @default.
- W2195071417 cites W2067833766 @default.
- W2195071417 cites W2068768932 @default.
- W2195071417 cites W2069578934 @default.
- W2195071417 cites W2070441922 @default.
- W2195071417 cites W2075596754 @default.
- W2195071417 cites W2079079821 @default.
- W2195071417 cites W2084098715 @default.
- W2195071417 cites W2087642255 @default.
- W2195071417 cites W2092057596 @default.
- W2195071417 cites W2092137231 @default.
- W2195071417 cites W2094137936 @default.
- W2195071417 cites W2094174396 @default.
- W2195071417 cites W2098993135 @default.
- W2195071417 cites W2099222347 @default.
- W2195071417 cites W2107432951 @default.
- W2195071417 cites W2108636417 @default.
- W2195071417 cites W2111762687 @default.
- W2195071417 cites W2111939910 @default.
- W2195071417 cites W2114224807 @default.
- W2195071417 cites W2115473542 @default.
- W2195071417 cites W2127787997 @default.
- W2195071417 cites W2128738437 @default.
- W2195071417 cites W2130118378 @default.
- W2195071417 cites W2130955026 @default.
- W2195071417 cites W2133923659 @default.
- W2195071417 cites W2134762997 @default.
- W2195071417 cites W2137516955 @default.
- W2195071417 cites W2139425275 @default.
- W2195071417 cites W2139951683 @default.
- W2195071417 cites W2141111229 @default.
- W2195071417 cites W2146081758 @default.