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• W2195093571 abstract "The discovery of over 150 monogenic epilepsies and advances in early genetic diagnoses have launched a search for molecular strategies and developmental timetables to reverse or even prevent the course of these debilitating brain disorders. Orthologous rodent models of key disease genes are providing important examples of the range of targets, and serve as valuable test systems for perinatal therapeutic approaches. While gene-specific analyses of single rare 'orphan' diseases are each narrow in scope, they illuminate downstream pathways converging onto interneurons, and treatments that strengthen inhibition during cortical maturation may provide broad protection against these seemingly disparate gene errors. Several genes, even those linked to malformations, show promise for postnatal correction before the onset of their clinical phenotype." @default.
• W2195093571 created "2016-06-24" @default.
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• W2195093571 date "2016-02-01" @default.
• W2195093571 modified "2023-09-27" @default.
• W2195093571 title "Early rescue of interneuron disease trajectory in developmental epilepsies" @default.
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• W2195093571 doi "https://doi.org/10.1016/j.conb.2015.10.007" @default.
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