FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2195155186> ?p ?o ?g. }

• W2195155186 endingPage "e0141220" @default.
• W2195155186 startingPage "e0141220" @default.
• W2195155186 abstract "During development, liver undergoes a rapid transition from a hematopoietic organ to a major organ for drug metabolism and nutrient homeostasis. However, little is known on a transcriptome level of the genes and RNA-splicing variants that are differentially regulated with age, and which up-stream regulators orchestrate age-specific biological functions in liver. We used RNA-Seq to interrogate the developmental dynamics of the liver transcriptome in mice at 12 ages from late embryonic stage (2-days before birth) to maturity (60-days after birth). Among 21,889 unique NCBI RefSeq-annotated genes, 9,641 were significantly expressed in at least one age, 7,289 were differently regulated with age, and 859 had multiple (> = 2) RNA splicing-variants. Factor analysis showed that the dynamics of hepatic genes fall into six distinct groups based on their temporal expression. The average expression of cytokines, ion channels, kinases, phosphatases, transcription regulators and translation regulators decreased with age, whereas the average expression of peptidases, enzymes and transmembrane receptors increased with age. The average expression of growth factors peak between Day-3 and Day-10, and decrease thereafter. We identified critical biological functions, upstream regulators, and putative transcription modules that seem to govern age-specific gene expression. We also observed differential ontogenic expression of known splicing variants of certain genes, and 1,455 novel splicing isoform candidates. In conclusion, the hepatic ontogeny of the transcriptome ontogeny has unveiled critical networks and up-stream regulators that orchestrate age-specific biological functions in liver, and suggest that age contributes to the complexity of the alternative splicing landscape of the hepatic transcriptome." @default.
• W2195155186 created "2016-06-24" @default.
• W2195155186 creator A5017344729 @default.
• W2195155186 creator A5029700070 @default.
• W2195155186 creator A5030329823 @default.
• W2195155186 creator A5059897495 @default.
• W2195155186 creator A5068046399 @default.
• W2195155186 creator A5076743166 @default.
• W2195155186 creator A5083842467 @default.
• W2195155186 date "2015-10-23" @default.
• W2195155186 modified "2023-09-25" @default.
• W2195155186 title "Deciphering the Developmental Dynamics of the Mouse Liver Transcriptome" @default.
• W2195155186 cites W102297612 @default.
• W2195155186 cites W1558611396 @default.
• W2195155186 cites W15647580 @default.
• W2195155186 cites W1590597519 @default.
• W2195155186 cites W1760727902 @default.
• W2195155186 cites W1888080914 @default.
• W2195155186 cites W1963090492 @default.
• W2195155186 cites W1981509058 @default.
• W2195155186 cites W1984708728 @default.
• W2195155186 cites W1992356089 @default.
• W2195155186 cites W2010233594 @default.
• W2195155186 cites W2011920499 @default.
• W2195155186 cites W2012139697 @default.
• W2195155186 cites W2012386903 @default.
• W2195155186 cites W2013833048 @default.
• W2195155186 cites W2014016589 @default.
• W2195155186 cites W2020642127 @default.
• W2195155186 cites W2021937150 @default.
• W2195155186 cites W2023190763 @default.
• W2195155186 cites W2023723464 @default.
• W2195155186 cites W2026330543 @default.
• W2195155186 cites W2031017582 @default.
• W2195155186 cites W2035165017 @default.
• W2195155186 cites W2037595666 @default.
• W2195155186 cites W2041575918 @default.
• W2195155186 cites W2042948416 @default.
• W2195155186 cites W2052497886 @default.
• W2195155186 cites W2052925329 @default.
• W2195155186 cites W2055770801 @default.
• W2195155186 cites W2062299199 @default.
• W2195155186 cites W2072765911 @default.
• W2195155186 cites W2081028309 @default.
• W2195155186 cites W2084975284 @default.
• W2195155186 cites W2087751835 @default.
• W2195155186 cites W2088477804 @default.
• W2195155186 cites W2096580672 @default.
• W2195155186 cites W2097065948 @default.
• W2195155186 cites W2097184538 @default.
• W2195155186 cites W2098832713 @default.
• W2195155186 cites W2099960100 @default.
• W2195155186 cites W2101651930 @default.
• W2195155186 cites W2103020094 @default.
• W2195155186 cites W2109557071 @default.
• W2195155186 cites W2109936378 @default.
• W2195155186 cites W2110065044 @default.
• W2195155186 cites W2110103300 @default.
• W2195155186 cites W2119884047 @default.
• W2195155186 cites W2122056961 @default.
• W2195155186 cites W2122527560 @default.
• W2195155186 cites W2127747731 @default.
• W2195155186 cites W2128016314 @default.
• W2195155186 cites W2136997107 @default.
• W2195155186 cites W2141458291 @default.
• W2195155186 cites W2142520006 @default.
• W2195155186 cites W2142709032 @default.
• W2195155186 cites W2143513235 @default.
• W2195155186 cites W2143965359 @default.
• W2195155186 cites W2147024792 @default.
• W2195155186 cites W2147407057 @default.
• W2195155186 cites W2147494036 @default.
• W2195155186 cites W2151806551 @default.
• W2195155186 cites W2154431984 @default.
• W2195155186 cites W2155069168 @default.
• W2195155186 cites W2160114795 @default.
• W2195155186 cites W2162143298 @default.
• W2195155186 cites W2168909179 @default.
• W2195155186 cites W2172116519 @default.
• W2195155186 cites W2413006633 @default.
• W2195155186 cites W2413399712 @default.
• W2195155186 cites W4232865341 @default.
• W2195155186 doi "https://doi.org/10.1371/journal.pone.0141220" @default.
• W2195155186 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4619800" @default.
• W2195155186 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26496202" @default.
• W2195155186 hasPublicationYear "2015" @default.
• W2195155186 type Work @default.
• W2195155186 sameAs 2195155186 @default.
• W2195155186 citedByCount "34" @default.
• W2195155186 countsByYear W21951551862016 @default.
• W2195155186 countsByYear W21951551862017 @default.
• W2195155186 countsByYear W21951551862018 @default.
• W2195155186 countsByYear W21951551862019 @default.
• W2195155186 countsByYear W21951551862020 @default.
• W2195155186 countsByYear W21951551862021 @default.
• W2195155186 countsByYear W21951551862022 @default.
• W2195155186 countsByYear W21951551862023 @default.
• W2195155186 crossrefType "journal-article" @default.

• next