FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2195451549> ?p ?o ?g. }

• W2195451549 endingPage "1499" @default.
• W2195451549 startingPage "1491" @default.
• W2195451549 abstract "<h3>Objective:</h3> To identify the clinical and structural MRI markers for predicting cognitive impairment (CI) in patients with neuromyelitis optica (NMO). <h3>Methods:</h3> Fifty-four patients with NMO and 27 healthy controls underwent extensive neuropsychological testing and multimodal 3.0T MRI. The patient group was classified as CI or cognitively preserved (CP), using a criterion of ≤1.5 SD on at least 2 cognitive domains. MRI measurements included white matter (WM) lesion volume, gray matter (GM), WM, and deep GM (DGM) volume, cortical thickness, and the severity and extent of WM tract diffusion metric alterations based on fractional anisotropy and mean, axial, and radial diffusivity. Groups were compared using a multivariate general linear model, and clinical and MRI measurements were related to average cognition <i>z</i> scores by partial correlations and a stepwise linear regression model. <h3>Results:</h3> Twenty-six patients with NMO (48.2%) were classified as CI and showed WM tract diffusion abnormalities, particularly increased radial diffusivity, and GM especially DGM atrophy compared with healthy controls. Patients classified as CP also showed alterations of WM tract diffusion but without significant GM atrophy. Compared with the CP group, patients with CI demonstrated a lower level of education and decreased hippocampal volume. In the whole patient group, average cognition <i>z</i> scores were best predicted by the level of education and hippocampal volume (<i>R</i>² = 0.46, <i>p</i> < 0.001). <h3>Conclusion:</h3> In patients with NMO, WM tract integrity disruption was identified in both CP and CI groups. GM atrophy, particularly in the DGM, was only found in the CI group. Hippocampal volume is the main MRI predictor of cognition in NMO." @default.
• W2195451549 created "2016-06-24" @default.
• W2195451549 creator A5009318195 @default.
• W2195451549 creator A5018006177 @default.
• W2195451549 creator A5018119212 @default.
• W2195451549 creator A5029594874 @default.
• W2195451549 creator A5030762103 @default.
• W2195451549 creator A5048043623 @default.
• W2195451549 creator A5049296141 @default.
• W2195451549 creator A5059761276 @default.
• W2195451549 creator A5064378373 @default.
• W2195451549 creator A5066905895 @default.
• W2195451549 creator A5070980028 @default.
• W2195451549 creator A5074416256 @default.
• W2195451549 creator A5083960293 @default.
• W2195451549 creator A5084148006 @default.
• W2195451549 date "2015-09-30" @default.
• W2195451549 modified "2023-10-06" @default.
• W2195451549 title "Structural MRI substrates of cognitive impairment in neuromyelitis optica" @default.
• W2195451549 cites W1743037390 @default.
• W2195451549 cites W1950012264 @default.
• W2195451549 cites W1974581106 @default.
• W2195451549 cites W1974620993 @default.
• W2195451549 cites W1994683739 @default.
• W2195451549 cites W2020625181 @default.
• W2195451549 cites W2027504287 @default.
• W2195451549 cites W2028734275 @default.
• W2195451549 cites W2028942474 @default.
• W2195451549 cites W2030451055 @default.
• W2195451549 cites W2034957520 @default.
• W2195451549 cites W2036388619 @default.
• W2195451549 cites W2053983047 @default.
• W2195451549 cites W2070991720 @default.
• W2195451549 cites W2071063637 @default.
• W2195451549 cites W2072110415 @default.
• W2195451549 cites W2073861322 @default.
• W2195451549 cites W2083148244 @default.
• W2195451549 cites W2084828153 @default.
• W2195451549 cites W2085936358 @default.
• W2195451549 cites W2089940272 @default.
• W2195451549 cites W2091934359 @default.
• W2195451549 cites W2104448214 @default.
• W2195451549 cites W2107941546 @default.
• W2195451549 cites W2110153487 @default.
• W2195451549 cites W2112165124 @default.
• W2195451549 cites W2114753322 @default.
• W2195451549 cites W2116128158 @default.
• W2195451549 cites W2130632081 @default.
• W2195451549 cites W2136132690 @default.
• W2195451549 cites W2141836159 @default.
• W2195451549 cites W2150667092 @default.
• W2195451549 cites W2151130155 @default.
• W2195451549 cites W2156086635 @default.
• W2195451549 cites W2161197854 @default.
• W2195451549 doi "https://doi.org/10.1212/wnl.0000000000002067" @default.
• W2195451549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26423432" @default.
• W2195451549 hasPublicationYear "2015" @default.
• W2195451549 type Work @default.
• W2195451549 sameAs 2195451549 @default.
• W2195451549 citedByCount "57" @default.
• W2195451549 countsByYear W21954515492016 @default.
• W2195451549 countsByYear W21954515492017 @default.
• W2195451549 countsByYear W21954515492018 @default.
• W2195451549 countsByYear W21954515492019 @default.
• W2195451549 countsByYear W21954515492020 @default.
• W2195451549 countsByYear W21954515492021 @default.
• W2195451549 countsByYear W21954515492022 @default.
• W2195451549 countsByYear W21954515492023 @default.
• W2195451549 crossrefType "journal-article" @default.
• W2195451549 hasAuthorship W2195451549A5009318195 @default.
• W2195451549 hasAuthorship W2195451549A5018006177 @default.
• W2195451549 hasAuthorship W2195451549A5018119212 @default.
• W2195451549 hasAuthorship W2195451549A5029594874 @default.
• W2195451549 hasAuthorship W2195451549A5030762103 @default.
• W2195451549 hasAuthorship W2195451549A5048043623 @default.
• W2195451549 hasAuthorship W2195451549A5049296141 @default.
• W2195451549 hasAuthorship W2195451549A5059761276 @default.
• W2195451549 hasAuthorship W2195451549A5064378373 @default.
• W2195451549 hasAuthorship W2195451549A5066905895 @default.
• W2195451549 hasAuthorship W2195451549A5070980028 @default.
• W2195451549 hasAuthorship W2195451549A5074416256 @default.
• W2195451549 hasAuthorship W2195451549A5083960293 @default.
• W2195451549 hasAuthorship W2195451549A5084148006 @default.
• W2195451549 hasConcept C126322002 @default.
• W2195451549 hasConcept C126838900 @default.
• W2195451549 hasConcept C14216870 @default.
• W2195451549 hasConcept C142724271 @default.
• W2195451549 hasConcept C143409427 @default.
• W2195451549 hasConcept C149550507 @default.
• W2195451549 hasConcept C15744967 @default.
• W2195451549 hasConcept C164705383 @default.
• W2195451549 hasConcept C169760540 @default.
• W2195451549 hasConcept C169900460 @default.
• W2195451549 hasConcept C2781172350 @default.
• W2195451549 hasConcept C2781192897 @default.
• W2195451549 hasConcept C2989005 @default.
• W2195451549 hasConcept C548259974 @default.
• W2195451549 hasConcept C71924100 @default.

• next