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- W2195487135 abstract "This article is part of a Special Issue Estradiol and Cognition. In estrogen-induced synaptic plasticity, a correlation of structure, function and behavior in the hippocampus has been widely established. 17ß-estradiol has been shown to increase dendritic spine density on hippocampal neurons and is accompanied by enhanced long-term potentiation and improved performance of animals in hippocampus-dependent memory tests. After inhibition of aromatase, the final enzyme of estradiol synthesis, with letrozole we consistently found a strong and significant impairment of long-term potentiation (LTP) in female mice as early as after six hours of treatment. LTP impairment was followed by loss of hippocampal spine synapses in the hippocampal CA1 area. Interestingly, these effects were not found in male animals. In the Morris water maze test, chronic administration of letrozole did not alter spatial learning and memory in either female or male mice. In humans, analogous effects of estradiol on hippocampal morphology and physiology were observed using neuroimaging techniques. However, similar to our findings in mice, an effect of estradiol on memory performance has not been consistently observed." @default.
- W2195487135 created "2016-06-24" @default.
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- W2195487135 date "2015-08-01" @default.
- W2195487135 modified "2023-10-15" @default.
- W2195487135 title "Structure–function–behavior relationship in estrogen-induced synaptic plasticity" @default.
- W2195487135 cites W1967230609 @default.
- W2195487135 cites W1975412200 @default.
- W2195487135 cites W1975759742 @default.
- W2195487135 cites W1976929239 @default.
- W2195487135 cites W1978728630 @default.
- W2195487135 cites W1978884020 @default.
- W2195487135 cites W1982341155 @default.
- W2195487135 cites W1984131837 @default.
- W2195487135 cites W1985080615 @default.
- W2195487135 cites W1986662149 @default.
- W2195487135 cites W1989431767 @default.
- W2195487135 cites W2002639930 @default.
- W2195487135 cites W2002710403 @default.
- W2195487135 cites W2003539800 @default.
- W2195487135 cites W2004225262 @default.
- W2195487135 cites W2005016581 @default.
- W2195487135 cites W2005737804 @default.
- W2195487135 cites W2010166612 @default.
- W2195487135 cites W2011506847 @default.
- W2195487135 cites W2021620837 @default.
- W2195487135 cites W2024630005 @default.
- W2195487135 cites W2025590886 @default.
- W2195487135 cites W2026804832 @default.
- W2195487135 cites W2027781855 @default.
- W2195487135 cites W2028665031 @default.
- W2195487135 cites W2028970529 @default.
- W2195487135 cites W2032679733 @default.
- W2195487135 cites W2034134656 @default.
- W2195487135 cites W2035357964 @default.
- W2195487135 cites W2037611373 @default.
- W2195487135 cites W2038439206 @default.
- W2195487135 cites W2041910867 @default.
- W2195487135 cites W2048229068 @default.
- W2195487135 cites W2050559000 @default.
- W2195487135 cites W2052669437 @default.
- W2195487135 cites W2052791472 @default.
- W2195487135 cites W2053672512 @default.
- W2195487135 cites W2054728846 @default.
- W2195487135 cites W2055247604 @default.
- W2195487135 cites W2055456545 @default.
- W2195487135 cites W2055917382 @default.
- W2195487135 cites W2056139665 @default.
- W2195487135 cites W2056154912 @default.
- W2195487135 cites W2058269906 @default.
- W2195487135 cites W2058768130 @default.
- W2195487135 cites W2059165844 @default.
- W2195487135 cites W2061076711 @default.
- W2195487135 cites W2065233722 @default.
- W2195487135 cites W2065912927 @default.
- W2195487135 cites W2069250997 @default.
- W2195487135 cites W2069930634 @default.
- W2195487135 cites W2072739064 @default.
- W2195487135 cites W2075840160 @default.
- W2195487135 cites W2077678165 @default.
- W2195487135 cites W2078219183 @default.
- W2195487135 cites W2082344236 @default.
- W2195487135 cites W2082861309 @default.
- W2195487135 cites W2083422851 @default.
- W2195487135 cites W2085210323 @default.
- W2195487135 cites W2089158506 @default.
- W2195487135 cites W2095078635 @default.
- W2195487135 cites W2096610613 @default.
- W2195487135 cites W2110451811 @default.
- W2195487135 cites W2110887671 @default.
- W2195487135 cites W2111375880 @default.
- W2195487135 cites W2114104729 @default.
- W2195487135 cites W2117800611 @default.
- W2195487135 cites W2118443528 @default.
- W2195487135 cites W2118743997 @default.
- W2195487135 cites W2119261700 @default.
- W2195487135 cites W2125898420 @default.
- W2195487135 cites W2136249808 @default.
- W2195487135 cites W2137775562 @default.
- W2195487135 cites W2137840050 @default.
- W2195487135 cites W2138341890 @default.
- W2195487135 cites W2143377924 @default.
- W2195487135 cites W2144741543 @default.
- W2195487135 cites W2145135770 @default.
- W2195487135 cites W2145424598 @default.
- W2195487135 cites W2145865543 @default.
- W2195487135 cites W2146126584 @default.
- W2195487135 cites W2150329556 @default.
- W2195487135 cites W2150771326 @default.
- W2195487135 cites W2151034458 @default.