Matches in SemOpenAlex for { <https://semopenalex.org/work/W2195512204> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2195512204 endingPage "4" @default.
- W2195512204 startingPage "14070" @default.
- W2195512204 abstract "The aim of this study was to explore the association of CpG islands methylation of liver kinase B1 (LKB1) with primary lung cancer and smoking, providing a theoretical basis for the demethylating drug to treat lung cancer by detecting the LKB1 promoter CpG methylation. mRNA expression of LKB1 were detected by in situ hybridization and methylation status on Hap II locus of the promoter of LKB1 was analyzed by methylation-specific polymerase chain reaction (PCR). 7 of 80 LKB1 positive cases had methylation on CpG islands while 18 of 44 LKB1 negative cases had methylation on CpG islands. The difference was significant between CpG island methylation and LKB1 expression. 8 of 54 cases of early and middle lung cancer were detected LKB1 promoter CpG island methylation while 30 controls were not detected, the difference was significant. 5 of 64 more-than-5-year cases had methylation on CpG islands while 20 of 60 less-than-5-year cases had methylation. The difference was significant between of 5-year survival and CpG island methylation of LKB1. 22 of 74 smoking cases of lung cancer had methylation on CpG islands of LKB1 while only 3 of 50 non-smoking cases had methylation. The difference of smoking and CpG island methylation of LKB1 was significant. LKB1 promoter CpG islands aberrant methylation is closely associated with the occurrence, development and prognosis of lung cancer, especially with smoking history including clinical early diagnosis and prognosis. CpG islands methylation in the promoter of LKB1 is likely important one of the mechanism of smoking-associated lung cancer." @default.
- W2195512204 created "2016-06-24" @default.
- W2195512204 creator A5006636063 @default.
- W2195512204 creator A5010589255 @default.
- W2195512204 creator A5053375208 @default.
- W2195512204 creator A5053982153 @default.
- W2195512204 creator A5056168495 @default.
- W2195512204 creator A5085639658 @default.
- W2195512204 creator A5089276634 @default.
- W2195512204 creator A5090427438 @default.
- W2195512204 date "2015-01-01" @default.
- W2195512204 modified "2023-09-26" @default.
- W2195512204 title "Liver kinase B1 promoter CpG island methylation is related to lung cancer and smoking." @default.
- W2195512204 cites W1577251139 @default.
- W2195512204 cites W1619256199 @default.
- W2195512204 cites W1980036031 @default.
- W2195512204 cites W1981052581 @default.
- W2195512204 cites W1983348452 @default.
- W2195512204 cites W1997828131 @default.
- W2195512204 cites W2002975917 @default.
- W2195512204 cites W2006902864 @default.
- W2195512204 cites W2008925501 @default.
- W2195512204 cites W2012419200 @default.
- W2195512204 cites W2013664313 @default.
- W2195512204 cites W2035556432 @default.
- W2195512204 cites W2048573827 @default.
- W2195512204 cites W2050285623 @default.
- W2195512204 cites W2065722660 @default.
- W2195512204 cites W2072398457 @default.
- W2195512204 cites W2075704676 @default.
- W2195512204 cites W2084821546 @default.
- W2195512204 cites W2132708041 @default.
- W2195512204 cites W2141744105 @default.
- W2195512204 cites W2157829770 @default.
- W2195512204 cites W2335700876 @default.
- W2195512204 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4613055" @default.
- W2195512204 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26550370" @default.
- W2195512204 hasPublicationYear "2015" @default.
- W2195512204 type Work @default.
- W2195512204 sameAs 2195512204 @default.
- W2195512204 citedByCount "4" @default.
- W2195512204 countsByYear W21955122042017 @default.
- W2195512204 countsByYear W21955122042020 @default.
- W2195512204 countsByYear W21955122042023 @default.
- W2195512204 crossrefType "journal-article" @default.
- W2195512204 hasAuthorship W2195512204A5006636063 @default.
- W2195512204 hasAuthorship W2195512204A5010589255 @default.
- W2195512204 hasAuthorship W2195512204A5053375208 @default.
- W2195512204 hasAuthorship W2195512204A5053982153 @default.
- W2195512204 hasAuthorship W2195512204A5056168495 @default.
- W2195512204 hasAuthorship W2195512204A5085639658 @default.
- W2195512204 hasAuthorship W2195512204A5089276634 @default.
- W2195512204 hasAuthorship W2195512204A5090427438 @default.
- W2195512204 hasConcept C104317684 @default.
- W2195512204 hasConcept C140173407 @default.
- W2195512204 hasConcept C143998085 @default.
- W2195512204 hasConcept C150194340 @default.
- W2195512204 hasConcept C153911025 @default.
- W2195512204 hasConcept C190727270 @default.
- W2195512204 hasConcept C2776256026 @default.
- W2195512204 hasConcept C2779277951 @default.
- W2195512204 hasConcept C33288867 @default.
- W2195512204 hasConcept C502942594 @default.
- W2195512204 hasConcept C54355233 @default.
- W2195512204 hasConcept C71924100 @default.
- W2195512204 hasConcept C86803240 @default.
- W2195512204 hasConceptScore W2195512204C104317684 @default.
- W2195512204 hasConceptScore W2195512204C140173407 @default.
- W2195512204 hasConceptScore W2195512204C143998085 @default.
- W2195512204 hasConceptScore W2195512204C150194340 @default.
- W2195512204 hasConceptScore W2195512204C153911025 @default.
- W2195512204 hasConceptScore W2195512204C190727270 @default.
- W2195512204 hasConceptScore W2195512204C2776256026 @default.
- W2195512204 hasConceptScore W2195512204C2779277951 @default.
- W2195512204 hasConceptScore W2195512204C33288867 @default.
- W2195512204 hasConceptScore W2195512204C502942594 @default.
- W2195512204 hasConceptScore W2195512204C54355233 @default.
- W2195512204 hasConceptScore W2195512204C71924100 @default.
- W2195512204 hasConceptScore W2195512204C86803240 @default.
- W2195512204 hasIssue "8" @default.
- W2195512204 hasLocation W21955122041 @default.
- W2195512204 hasOpenAccess W2195512204 @default.
- W2195512204 hasPrimaryLocation W21955122041 @default.
- W2195512204 hasRelatedWork W1957046050 @default.
- W2195512204 hasRelatedWork W1975104948 @default.
- W2195512204 hasRelatedWork W1988403972 @default.
- W2195512204 hasRelatedWork W2009325917 @default.
- W2195512204 hasRelatedWork W2078166100 @default.
- W2195512204 hasRelatedWork W2089104774 @default.
- W2195512204 hasRelatedWork W2093017020 @default.
- W2195512204 hasRelatedWork W2166901579 @default.
- W2195512204 hasRelatedWork W2486024774 @default.
- W2195512204 hasRelatedWork W3152305951 @default.
- W2195512204 hasVolume "8" @default.
- W2195512204 isParatext "false" @default.
- W2195512204 isRetracted "false" @default.
- W2195512204 magId "2195512204" @default.
- W2195512204 workType "article" @default.