FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2195516753> ?p ?o ?g. }

• W2195516753 endingPage "e1483" @default.
• W2195516753 startingPage "e1483" @default.
• W2195516753 abstract "Mechanical ventilation (MV) of patients can cause damage to bronchoalveolar epithelium, leading to a sterile inflammatory response, infection and in severe cases sepsis. Limited knowledge is available on the effects of MV on the innate immune defense system in the human lung. In this study, we demonstrate that cyclic stretch of the human bronchial epithelial cell lines VA10 and BCi NS 1.1 leads to down-regulation of cathelicidin antimicrobial peptide ( CAMP ) gene expression. We show that treatment of VA10 cells with vitamin D3 and/or 4-phenyl butyric acid counteracted cyclic stretch mediated down-regulation of CAMP mRNA and protein expression (LL-37). Further, we observed an increase in pro-inflammatory responses in the VA10 cell line subjected to cyclic stretch. The mRNA expression of the genes encoding pro-inflammatory cytokines IL-8 and IL-1 β was increased after cyclic stretching, where as a decrease in gene expression of chemokines IP-10 and RANTES was observed. Cyclic stretch enhanced oxidative stress in the VA10 cells. The mRNA expression of toll-like receptor ( TLR ) 3 , TLR5 and TLR8 was reduced, while the gene expression of TLR2 was increased in VA10 cells after cyclic stretch. In conclusion, our in vitro results indicate that cyclic stretch may differentially modulate innate immunity by down-regulation of antimicrobial peptide expression and increase in pro-inflammatory responses." @default.
• W2195516753 created "2016-06-24" @default.
• W2195516753 creator A5017466174 @default.
• W2195516753 creator A5038677193 @default.
• W2195516753 creator A5039108392 @default.
• W2195516753 creator A5062170890 @default.
• W2195516753 creator A5091075447 @default.
• W2195516753 date "2015-12-07" @default.
• W2195516753 modified "2023-10-03" @default.
• W2195516753 title "Cyclic mechanical stretch down-regulates cathelicidin antimicrobial peptide expression and activates a pro-inflammatory response in human bronchial epithelial cells" @default.
• W2195516753 cites W1500925296 @default.
• W2195516753 cites W1583831774 @default.
• W2195516753 cites W1844316610 @default.
• W2195516753 cites W1876407697 @default.
• W2195516753 cites W1902310782 @default.
• W2195516753 cites W1910618583 @default.
• W2195516753 cites W1964758221 @default.
• W2195516753 cites W1972181361 @default.
• W2195516753 cites W1983337716 @default.
• W2195516753 cites W1984520102 @default.
• W2195516753 cites W1988177557 @default.
• W2195516753 cites W1993244478 @default.
• W2195516753 cites W1993491358 @default.
• W2195516753 cites W2018274677 @default.
• W2195516753 cites W2021800929 @default.
• W2195516753 cites W2024806925 @default.
• W2195516753 cites W2034459537 @default.
• W2195516753 cites W2048814498 @default.
• W2195516753 cites W2051930121 @default.
• W2195516753 cites W2063116767 @default.
• W2195516753 cites W2077925256 @default.
• W2195516753 cites W2079170112 @default.
• W2195516753 cites W2084141237 @default.
• W2195516753 cites W2090407536 @default.
• W2195516753 cites W2099058959 @default.
• W2195516753 cites W2107277218 @default.
• W2195516753 cites W2111187630 @default.
• W2195516753 cites W2112915641 @default.
• W2195516753 cites W2113540967 @default.
• W2195516753 cites W2116558722 @default.
• W2195516753 cites W2117075813 @default.
• W2195516753 cites W2123184578 @default.
• W2195516753 cites W2125766343 @default.
• W2195516753 cites W2128862717 @default.
• W2195516753 cites W2130318026 @default.
• W2195516753 cites W2130855144 @default.
• W2195516753 cites W2147852098 @default.
• W2195516753 cites W2157339124 @default.
• W2195516753 cites W2160943337 @default.
• W2195516753 cites W2167836952 @default.
• W2195516753 cites W2168139169 @default.
• W2195516753 cites W2192080449 @default.
• W2195516753 cites W2227906064 @default.
• W2195516753 cites W2228300111 @default.
• W2195516753 cites W2888571 @default.
• W2195516753 cites W2146431105 @default.
• W2195516753 doi "https://doi.org/10.7717/peerj.1483" @default.
• W2195516753 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4675098" @default.
• W2195516753 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26664810" @default.
• W2195516753 hasPublicationYear "2015" @default.
• W2195516753 type Work @default.
• W2195516753 sameAs 2195516753 @default.
• W2195516753 citedByCount "7" @default.
• W2195516753 countsByYear W21955167532016 @default.
• W2195516753 countsByYear W21955167532018 @default.
• W2195516753 countsByYear W21955167532020 @default.
• W2195516753 countsByYear W21955167532021 @default.
• W2195516753 crossrefType "journal-article" @default.
• W2195516753 hasAuthorship W2195516753A5017466174 @default.
• W2195516753 hasAuthorship W2195516753A5038677193 @default.
• W2195516753 hasAuthorship W2195516753A5039108392 @default.
• W2195516753 hasAuthorship W2195516753A5062170890 @default.
• W2195516753 hasAuthorship W2195516753A5091075447 @default.
• W2195516753 hasBestOaLocation W21955167531 @default.
• W2195516753 hasConcept C104317684 @default.
• W2195516753 hasConcept C129437159 @default.
• W2195516753 hasConcept C13373296 @default.
• W2195516753 hasConcept C136449434 @default.
• W2195516753 hasConcept C150194340 @default.
• W2195516753 hasConcept C185592680 @default.
• W2195516753 hasConcept C203014093 @default.
• W2195516753 hasConcept C2776070231 @default.
• W2195516753 hasConcept C2776914184 @default.
• W2195516753 hasConcept C2777379352 @default.
• W2195516753 hasConcept C2781236682 @default.
• W2195516753 hasConcept C4937899 @default.
• W2195516753 hasConcept C540938839 @default.
• W2195516753 hasConcept C55493867 @default.
• W2195516753 hasConcept C62478195 @default.
• W2195516753 hasConcept C68324877 @default.
• W2195516753 hasConcept C86803240 @default.
• W2195516753 hasConcept C8891405 @default.
• W2195516753 hasConcept C89423630 @default.
• W2195516753 hasConcept C95444343 @default.
• W2195516753 hasConceptScore W2195516753C104317684 @default.
• W2195516753 hasConceptScore W2195516753C129437159 @default.
• W2195516753 hasConceptScore W2195516753C13373296 @default.
• W2195516753 hasConceptScore W2195516753C136449434 @default.

• next