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- W2195587321 abstract "Summary The predictable pharmacokinetic drug interaction between clozapine and rifampicin is listed in most standard reference texts but little detail is given or emphasis on its clinical significance. The interaction is based on theoretical knowledge of both drugs; to date just two case reports have been published. This article describes a third case demonstrating the significance of this interaction. This was potentially devastating for the patient who required an extended psychiatric admission. The enzyme induction was so potent that the dose of clozapine had to be increased approximately sixfold. Careful management of this significant interaction is essential for effective patient care." @default.
- W2195587321 created "2016-06-24" @default.
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- W2195587321 date "2016-06-01" @default.
- W2195587321 modified "2023-09-28" @default.
- W2195587321 title "Prescribing clozapine and rifampicin: clinical impact of their interaction" @default.
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- W2195587321 doi "https://doi.org/10.1192/pb.bp.115.051250" @default.
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