FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2195731101> ?p ?o ?g. }

• W2195731101 endingPage "1082" @default.
• W2195731101 startingPage "1071" @default.
• W2195731101 abstract "Little is known about the biology of meniscal allograft transplantation in humans. In particular, little information is available about the phenotype of the cells that repopulate the allograft, whether an immune response is elicited against the graft, and whether the repopulating cells synthesize normal extracellular matrix components.A small biopsy specimen of the meniscal allograft (twenty-eight menisci in twenty-five patients) and the adjacent synovial membrane (sixteen patients) was harvested during follow-up arthroscopy in patients who had undergone meniscal allograft transplantation at a mean of sixteen months earlier. Seventeen patients had undergone concomitant reconstruction of the anterior cruciate ligament with an allograft. Normal menisci (unimplanted allografts) and synovial specimens from age-matched controls were examined as well. All twenty-eight meniscal allografts were examined histologically. Immunohistochemical analysis was carried out on ten menisci and nine synovial specimens with use of monoclonal antibodies to class-I and class-II major histocompatibility complex antigens, CD-8, CD-11b, and CD-19 epitopes, as well as other epitopes, to demonstrate immunogenic macromolecules, cytotoxic T-lymphocytes, activated macrophages, and B-lymphocytes.Most of the specimens demonstrated incomplete repopulation with viable cells. The repopulating cells stained positively with phenotype markers for both synovial cells and fibroblasts. Polarized light microscopy demonstrated evidence of active remodeling of the matrix. The cells in frozen, unimplanted menisci stained positively for class-I and class-II human leukocyte antigens, indicating immunogenicity at the time of transplantation. Overall, nine of twelve specimens contained immunoreactive cells (B-lymphocytes or cytotoxic T-cells) in the meniscus or synovial tissue. However, only a small number of these cells was present. There was no evidence of frank immunological rejection. The clinical outcome (success or failure of the transplant) was not related to the overall histological score or to the presence of an immune response in the meniscal or synovial biopsy specimen.Human meniscal allograft transplants are repopulated with cells that appear to be derived from the synovial membrane; these cells appear to actively remodel the matrix. Although there is histological evidence of an immune response directed against the transplant, this response does not appear to affect the clinical outcome. The presence of histocompatibility antigens on the meniscal surface at the time of transplantation (even after freezing) indicates the potential for an immune response against the transplant.Despite the absence of frank immunological rejection, a subtle immune reaction may affect the healing, incorporation, and revascularization of the graft. It is possible that the structural remodeling associated with cellular repopulation may render the meniscus more susceptible to injury." @default.
• W2195731101 created "2016-06-24" @default.
• W2195731101 creator A5010416890 @default.
• W2195731101 creator A5050312260 @default.
• W2195731101 creator A5057190775 @default.
• W2195731101 creator A5063311766 @default.
• W2195731101 creator A5084422934 @default.
• W2195731101 creator A5090554610 @default.
• W2195731101 date "2000-08-01" @default.
• W2195731101 modified "2023-10-18" @default.
• W2195731101 title "Histological Analysis of Human Meniscal Allografts" @default.
• W2195731101 cites W1984763554 @default.
• W2195731101 cites W1999942374 @default.
• W2195731101 cites W2009426950 @default.
• W2195731101 cites W2015523468 @default.
• W2195731101 cites W2016162093 @default.
• W2195731101 cites W2025153838 @default.
• W2195731101 cites W2058694343 @default.
• W2195731101 cites W2103551716 @default.
• W2195731101 cites W2113911966 @default.
• W2195731101 cites W2134965978 @default.
• W2195731101 cites W2180722336 @default.
• W2195731101 cites W2235894342 @default.
• W2195731101 cites W2287407002 @default.
• W2195731101 cites W2290655748 @default.
• W2195731101 cites W2339585521 @default.
• W2195731101 cites W2886236895 @default.
• W2195731101 doi "https://doi.org/10.2106/00004623-200008000-00002" @default.
• W2195731101 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10954095" @default.
• W2195731101 hasPublicationYear "2000" @default.
• W2195731101 type Work @default.
• W2195731101 sameAs 2195731101 @default.
• W2195731101 citedByCount "204" @default.
• W2195731101 countsByYear W21957311012012 @default.
• W2195731101 countsByYear W21957311012013 @default.
• W2195731101 countsByYear W21957311012014 @default.
• W2195731101 countsByYear W21957311012015 @default.
• W2195731101 countsByYear W21957311012016 @default.
• W2195731101 countsByYear W21957311012017 @default.
• W2195731101 countsByYear W21957311012018 @default.
• W2195731101 countsByYear W21957311012019 @default.
• W2195731101 countsByYear W21957311012020 @default.
• W2195731101 countsByYear W21957311012021 @default.
• W2195731101 countsByYear W21957311012022 @default.
• W2195731101 countsByYear W21957311012023 @default.
• W2195731101 crossrefType "journal-article" @default.
• W2195731101 hasAuthorship W2195731101A5010416890 @default.
• W2195731101 hasAuthorship W2195731101A5050312260 @default.
• W2195731101 hasAuthorship W2195731101A5057190775 @default.
• W2195731101 hasAuthorship W2195731101A5063311766 @default.
• W2195731101 hasAuthorship W2195731101A5084422934 @default.
• W2195731101 hasAuthorship W2195731101A5090554610 @default.
• W2195731101 hasConcept C120665830 @default.
• W2195731101 hasConcept C121332964 @default.
• W2195731101 hasConcept C141071460 @default.
• W2195731101 hasConcept C142724271 @default.
• W2195731101 hasConcept C147483822 @default.
• W2195731101 hasConcept C154317977 @default.
• W2195731101 hasConcept C159654299 @default.
• W2195731101 hasConcept C189178095 @default.
• W2195731101 hasConcept C195616568 @default.
• W2195731101 hasConcept C202751555 @default.
• W2195731101 hasConcept C203014093 @default.
• W2195731101 hasConcept C2776914184 @default.
• W2195731101 hasConcept C2777652487 @default.
• W2195731101 hasConcept C2780868878 @default.
• W2195731101 hasConcept C2911091166 @default.
• W2195731101 hasConcept C542903549 @default.
• W2195731101 hasConcept C55493867 @default.
• W2195731101 hasConcept C61511704 @default.
• W2195731101 hasConcept C71924100 @default.
• W2195731101 hasConcept C86803240 @default.
• W2195731101 hasConceptScore W2195731101C120665830 @default.
• W2195731101 hasConceptScore W2195731101C121332964 @default.
• W2195731101 hasConceptScore W2195731101C141071460 @default.
• W2195731101 hasConceptScore W2195731101C142724271 @default.
• W2195731101 hasConceptScore W2195731101C147483822 @default.
• W2195731101 hasConceptScore W2195731101C154317977 @default.
• W2195731101 hasConceptScore W2195731101C159654299 @default.
• W2195731101 hasConceptScore W2195731101C189178095 @default.
• W2195731101 hasConceptScore W2195731101C195616568 @default.
• W2195731101 hasConceptScore W2195731101C202751555 @default.
• W2195731101 hasConceptScore W2195731101C203014093 @default.
• W2195731101 hasConceptScore W2195731101C2776914184 @default.
• W2195731101 hasConceptScore W2195731101C2777652487 @default.
• W2195731101 hasConceptScore W2195731101C2780868878 @default.
• W2195731101 hasConceptScore W2195731101C2911091166 @default.
• W2195731101 hasConceptScore W2195731101C542903549 @default.
• W2195731101 hasConceptScore W2195731101C55493867 @default.
• W2195731101 hasConceptScore W2195731101C61511704 @default.
• W2195731101 hasConceptScore W2195731101C71924100 @default.
• W2195731101 hasConceptScore W2195731101C86803240 @default.
• W2195731101 hasIssue "8" @default.
• W2195731101 hasLocation W21957311011 @default.
• W2195731101 hasLocation W21957311012 @default.
• W2195731101 hasOpenAccess W2195731101 @default.
• W2195731101 hasPrimaryLocation W21957311011 @default.
• W2195731101 hasRelatedWork W1560414607 @default.

• next