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• W2195865802 abstract "Future Medicinal ChemistryVol. 7, No. 17 CommentaryPeptide triazole inactivators of HIV-1: how do they work and what is their potential?Irwin Chaiken & Adel A RashadIrwin Chaiken*Author for correspondence: E-mail Address: irwin.chaiken@drexelmed.edu Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USASearch for more papers by this author & Adel A Rashad Department of Biochemistry & Molecular Biology, Drexel University College of Medicine, Philadelphia, PA 19102, USASearch for more papers by this authorPublished Online:24 Nov 2015https://doi.org/10.4155/fmc.15.152AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: AIDScell entryenvelope protein antagonismHIV-1infection inhibitionmacrocyclepeptidomimeticsvirus inactivationReferences1 Acharya P, Lusvarghi S, Bewley CA, Kwong PD. 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A model of peptide triazole entry inhibitor binding to HIV-1 gp120 and the mechanism of bridging sheet disruption. Biochemistry 52(13), 2245–2261 (2013).Crossref, Medline, CAS, Google Scholar24 Aneja R, Rashad AA, Li H et al. Peptide triazole inactivators of HIV-1 utilize a conserved two-cavity binding site at the junction of the inner and outer domains of Env gp120. J. Med. Chem. 58(9), 3843–3858 (2015).Crossref, Medline, CAS, Google Scholar25 Rashad AA, Kalyana Sundaram RV, Aneja R, Duffy C, Chaiken I. Macrocyclic envelope glycoprotein antagonists that irreversibly inactivate HIV-1 before host cell encounter. J. Med. Chem. 58(18), 7603–7608 (2015).Crossref, Medline, CAS, Google Scholar26 Rashad AA, Kalyana Sundaram RV, Nangarlia A, Aneja R, Duffy C, Chaiken I. Macrocyclic HIV-1 envelope glycoprotein antagonists. Presented at: Structural Biology Related to HIV/AIDS. Natcher Conference Center, Bethesda, Maryland, USA, 18–19 June 2015.Google Scholar27 Bastian AR. Irreversible breakdown of HIV-1 by peptide triazole thiols and multivalent gold nanoparticle conjugates [PhD thesis]. Ann Arbor, Drexel University, MI, USA (2014).Google ScholarFiguresReferencesRelatedDetailsCited ByAltered Env conformational dynamics as a mechanism of resistance to peptide-triazole HIV-1 inactivators9 October 2021 | Retrovirology, Vol. 18, No. 1Therapeutic potential of HIV-1 entry inhibitor peptidomimetics17 February 2021 | Experimental Biology and Medicine, Vol. 246, No. 9Protein- and Peptide-Based Virus Inactivators: Inactivating Viruses Before Their Entry Into Cells25 May 2020 | Frontiers in Microbiology, Vol. 11Recognition of HIV-inactivating peptide triazoles by the recombinant soluble Env trimer, BG505 SOSIP.66411 March 2017 | Proteins: Structure, Function, and Bioinformatics, Vol. 85, No. 5Targeting cell surface HIV-1 Env protein to suppress infectious virus formationVirus Research, Vol. 235Chemical optimization of macrocyclic HIV-1 inactivators for improving potency and increasing the structural diversity at the triazole ring1 January 2017 | Organic & Biomolecular Chemistry, Vol. 15, No. 37Pyrazolo[1,5-a]pyrimidine-based macrocycles as novel HIV-1 inhibitors: a patent evaluation of WO201512318219 July 2016 | Expert Opinion on Therapeutic Patents, Vol. 26, No. 9 Vol. 7, No. 17 Follow us on social media for the latest updates Metrics Downloaded 55 times History Published online 24 November 2015 Published in print November 2015 Information© Future science LtdKeywordsAIDScell entryenvelope protein antagonismHIV-1infection inhibitionmacrocyclepeptidomimeticsvirus inactivationFinancial & competing interests disclosurePeptide triazole studies have been supported by National Institutes of General Medical Sciences and Allergy and Infectious Diseases, NIH; National Science Foundation; United States Agency for international Development; WW Smith Charitable Trust; Schlumberger Foundation; and Drexel University. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download" @default.
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