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• W2195870368 abstract "Enhanced adrenergic drive is involved in the development of left ventricular (LV) diastolic dysfunction observed in metabolic syndrome (MS). Thus, β-blockers might improve LV dysfunction observed in MS, but whether this occurs is unknown. We assessed in Zucker fa/fa rats the effects of short- (5 days) and long-term (90 days) metoprolol (‘pure’ β-blockade; 80 mg/kg/day) or nebivolol (β-blocker with vasodilating properties; 5 mg/kg/day) treatment on LV hemodynamics and remodeling, as well as the long-term effects on coronary and peripheral endothelial dysfunction. At identical degree of β1-receptor blockade, metoprolol and nebivolol decreased heart rate to the same extent and preserved cardiac output via increased stroke volume. None of the β-blockers, either after long- or short-term administration, modified LV end-systolic pressure-volume relation. Both β-blockers reduced, after long-term administration, LV end-diastolic pressure, Tau and end-diastolic pressure-volume relation, and this was associated with reduced LV collagen density, but not heart weight. Similar hemodynamic effects were also observed after short-term nebivolol, but not short-term metoprolol. These short-term effects of nebivolol were abolished by NO synthase inhibition. At the vascular level, nebivolol, and to a lesser extend metoprolol, improved NO dependent coronary vasorelaxation, which was abolished by NO synthase inhibition. In a model of MS, the β-blockers metoprolol and nebivolol improve to the same extent LV hemodynamics, remodeling and diastolic function, but nebivolol prevent more markedly endothelium dependent vasorelaxation involving a more marked enhancement of NO bio-availability." @default.
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• W2195870368 date "2011-08-01" @default.
• W2195870368 modified "2023-09-27" @default.
• W2195870368 title "Improvement of left ventricular diastolic function induced by β-blockade" @default.
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• W2195870368 doi "https://doi.org/10.1016/j.yjmcc.2011.05.012" @default.
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