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- W2196099160 abstract "This chapter discusses the eradication of tumor by adoptive transfer of cytotoxic T lymphocytes. Complete and permanent eradication of tumors by histocompatability complex (MHC) class I restricted CD8+ tumor-specific cytotoxic T lymphocytes (CTLs) can be achieved in a variety of experimental murine models. In human metastatic melanoma, CD8+ tumor-specific CTLs are probably therapeutically the most active components among lymphokine-activated killer or tumor-infiltrating lymphocytes cells, with a possibly important contribution by CD4+ cells in some patients, although no clinical experience with cloned T cells exists as yet to evaluate this point. Cancer cells can avoid the induction of and destruction by tumorspecific CTLs in a number of ways, some of which can be manipulated to increase the efficacy of sensitization or adoptive therapy. T cell therapy allows targeting on minute changes in any cellular peptide that is presentable in the context of MHC molecules. CD8+ CTLs stand out as remarkably effective in tumor eradication in view of their remarkable potency, and specificity in allograft rejection and antiviral immunity." @default.
- W2196099160 created "2016-06-24" @default.
- W2196099160 creator A5035565968 @default.
- W2196099160 date "1992-01-01" @default.
- W2196099160 modified "2023-10-03" @default.
- W2196099160 title "Tumor Eradication by Adoptive Transfer of Cytototic T Lymphocytes" @default.
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