Matches in SemOpenAlex for { <https://semopenalex.org/work/W2196171657> ?p ?o ?g. }
Showing items 1 to 76 of
76
with 100 items per page.
- W2196171657 endingPage "R1407" @default.
- W2196171657 startingPage "R1397" @default.
- W2196171657 abstract "An enhanced sympathetic nerve activity (SNA) has been implicated in the development and maintenance of the hypertension observed in experimental animal models such as the spontaneously hypertensive rat (SHR). Recent evidence suggests that an alteration of sympathetic synaptic transmission could also play a significant role in the elevation of SNA observed in the SHR (J. C. Magee and G. G. Schofield. Hypertension Dallas 20: 367-373, 1992). To test this hypothesis, we used intracellular recordings from superior cervical ganglion (SCG) neurons to compare properties of synaptic transmission between SHRs and two normotensive controls [Wistar-Kyoto (WKY) and Wistar rats]. Supramaximal preganglionic stimulation elicited larger amplitude fast excitatory postsynaptic potentials (EPSPs) and currents (EPSCs) in SHR sympathetic neurons compared with the normotensive controls. Analysis of variance of both compound and unitary EPSC amplitudes suggests that an increase in transmitter release is responsible for the elevated EPSP amplitude in these neurons. Also, a diminished short-term facilitation and an elevated synaptic depression limit the ability of SHR preganglionic neurons to increase transmitter release during short trains of repetitive stimuli. It is hypothesized that an enhanced transmitter depletion results in the altered synaptic plasticity of SHR sympathetic ganglion neurons. Intracellular recordings in low-Ca2+, high-Mg2+ external solutions support this idea. Therefore, synaptic transmission between the preganglionic and postganglionic neurons of SCGs from hypertensive rats was found to be altered in a manner that would tend to enhance sympathetic nervous activity, further implicating an exaggerated SNA in the pathogenesis of hypertension in the SHR model." @default.
- W2196171657 created "2016-06-24" @default.
- W2196171657 creator A5043288520 @default.
- W2196171657 creator A5057308878 @default.
- W2196171657 date "1994-11-01" @default.
- W2196171657 modified "2023-09-27" @default.
- W2196171657 title "Alterations of synaptic transmission in sympathetic ganglia of spontaneously hypertensive rats" @default.
- W2196171657 doi "https://doi.org/10.1152/ajpregu.1994.267.5.r1397" @default.
- W2196171657 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7977871" @default.
- W2196171657 hasPublicationYear "1994" @default.
- W2196171657 type Work @default.
- W2196171657 sameAs 2196171657 @default.
- W2196171657 citedByCount "14" @default.
- W2196171657 countsByYear W21961716572012 @default.
- W2196171657 countsByYear W21961716572018 @default.
- W2196171657 countsByYear W21961716572019 @default.
- W2196171657 countsByYear W21961716572022 @default.
- W2196171657 crossrefType "journal-article" @default.
- W2196171657 hasAuthorship W2196171657A5043288520 @default.
- W2196171657 hasAuthorship W2196171657A5057308878 @default.
- W2196171657 hasConcept C112592302 @default.
- W2196171657 hasConcept C126322002 @default.
- W2196171657 hasConcept C134018914 @default.
- W2196171657 hasConcept C169760540 @default.
- W2196171657 hasConcept C170493617 @default.
- W2196171657 hasConcept C17077164 @default.
- W2196171657 hasConcept C185592680 @default.
- W2196171657 hasConcept C197341189 @default.
- W2196171657 hasConcept C200170125 @default.
- W2196171657 hasConcept C2776533406 @default.
- W2196171657 hasConcept C2777646271 @default.
- W2196171657 hasConcept C2778086073 @default.
- W2196171657 hasConcept C29561615 @default.
- W2196171657 hasConcept C71924100 @default.
- W2196171657 hasConcept C84393581 @default.
- W2196171657 hasConcept C86803240 @default.
- W2196171657 hasConcept C98229152 @default.
- W2196171657 hasConceptScore W2196171657C112592302 @default.
- W2196171657 hasConceptScore W2196171657C126322002 @default.
- W2196171657 hasConceptScore W2196171657C134018914 @default.
- W2196171657 hasConceptScore W2196171657C169760540 @default.
- W2196171657 hasConceptScore W2196171657C170493617 @default.
- W2196171657 hasConceptScore W2196171657C17077164 @default.
- W2196171657 hasConceptScore W2196171657C185592680 @default.
- W2196171657 hasConceptScore W2196171657C197341189 @default.
- W2196171657 hasConceptScore W2196171657C200170125 @default.
- W2196171657 hasConceptScore W2196171657C2776533406 @default.
- W2196171657 hasConceptScore W2196171657C2777646271 @default.
- W2196171657 hasConceptScore W2196171657C2778086073 @default.
- W2196171657 hasConceptScore W2196171657C29561615 @default.
- W2196171657 hasConceptScore W2196171657C71924100 @default.
- W2196171657 hasConceptScore W2196171657C84393581 @default.
- W2196171657 hasConceptScore W2196171657C86803240 @default.
- W2196171657 hasConceptScore W2196171657C98229152 @default.
- W2196171657 hasIssue "5" @default.
- W2196171657 hasLocation W21961716571 @default.
- W2196171657 hasLocation W21961716572 @default.
- W2196171657 hasOpenAccess W2196171657 @default.
- W2196171657 hasPrimaryLocation W21961716571 @default.
- W2196171657 hasRelatedWork W159464688 @default.
- W2196171657 hasRelatedWork W1968793633 @default.
- W2196171657 hasRelatedWork W1977695003 @default.
- W2196171657 hasRelatedWork W2095658396 @default.
- W2196171657 hasRelatedWork W2122090986 @default.
- W2196171657 hasRelatedWork W2196171657 @default.
- W2196171657 hasRelatedWork W2252302924 @default.
- W2196171657 hasRelatedWork W2897075501 @default.
- W2196171657 hasRelatedWork W2954096078 @default.
- W2196171657 hasRelatedWork W4321095294 @default.
- W2196171657 hasVolume "267" @default.
- W2196171657 isParatext "false" @default.
- W2196171657 isRetracted "false" @default.
- W2196171657 magId "2196171657" @default.
- W2196171657 workType "article" @default.