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- W2196268244 abstract "As a low-affinity neurotrophins receptor, p75 neurotrophin receptor (p75NTR) is a transmembrane receptor involved in a diverse array of cellular responses, including apoptosis, survival, neurite outgrowth, migration, and cell cycle arrest, which may be related to some neurological disorders, such as Alzheimer’s disease (AD), schizophrenia, major depressive disorder (MDD), posttraumatic stress disorder (PTSD), amyotrophic lateral sclerosis (ALS), and Parkinson’s disease (PD). Indeed, a series of studies during the last decade has demonstrated that the p75NTR signaling plays key roles in most aspects of the neurological disorder diseases. In spite of the limited information available, this review still tried to summary the relationship between p75NTR and diverse neurological disorder diseases, and tried to further clarify the possible mechanism, which may provide a novel therapeutic target for the treatment of neurological disorders." @default.
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- W2196268244 date "2015-12-01" @default.
- W2196268244 modified "2023-10-18" @default.
- W2196268244 title "Update on the role of p75NTR in neurological disorders: A novel therapeutic target" @default.
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- W2196268244 doi "https://doi.org/10.1016/j.biopha.2015.10.010" @default.
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