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- W21962857 abstract "Abstract The molecular basis for the immune dysfunction that accompanies psychological distress is unknown. The purpose of this study was to determine whether epigenetic modifications underlie this immune dysregulation. Women newly diagnosed with early stage breast cancer were enrolled into the study and psychological, immunological and epigenetic assessments were made at diagnosis and four months later, after completion of cancer treatment. At diagnosis women reported increased perceived stress, anxiety, and mood disturbance and the peripheral blood mononuclear cells (PBMC) of these women exhibited reduced natural killer cell activity and reduced production of interferon gamma, which contrasted with results, obtained after completion of treatment. At the epigenetic level, the PBMC of these women at diagnosis exhibited distinct epigenetic patterns, with reduced nuclear acetylation of histone residues H4-K8 and H4-K12, as well as reduced phosphorylation of H3-S10, when compared to PBMC derived after the completion of treatment. PBMC function (natural killer cell activity and interferon-gamma production) associated with nuclear acetylation and phosphorylation status of these histone residues. These findings demonstrate associations among PBMC nuclear epigenetic patterns and the immune dysregulation that accompanies psychosocial distress." @default.
- W21962857 created "2016-06-24" @default.
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- W21962857 date "2011-04-01" @default.
- W21962857 modified "2023-09-23" @default.
- W21962857 title "Immune dysregulation by psychological distress (113.26)" @default.
- W21962857 doi "https://doi.org/10.4049/jimmunol.186.supp.113.26" @default.
- W21962857 hasPublicationYear "2011" @default.
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