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- W2196337416 abstract "Two well-known compounds, tingenone and pristimerin were isolated from column chromatography of a mixture of n-hexane and etlylacetate crude extracts of the whole root of Salacia oliveriana plant. This is the first report on the phytochemistry of the plant. The structures of the compounds were determined by means of 1 H and 13 C NMR spectroscopy as well as 2D NMR (COSY, HSQC and HMBC) and in comparison with existing literature. Tingenone and pristimerin were evaluated for potential antimicrobial activity against medically important bacteria (eleven) and three fungal strains. Their antimicrobial activities were determined using punched agar diffusion and serial dilution methods. Different concentrations of the compounds (200, 100, 50, 25 12.5, 6.25, 3.125mg/mL) were used in the study. Zones of inhibition were compared with that of standards gentamicin for antibacterial and tioconazole for antifungal activities. The results showed that remarkable inhibition of the bacterial and fungal growth was shown against the tested organisms, Escherichia coli, Staphylococcus aureus, Salmonella typhii, Bacillus subtilis, Staphylococcus albus, Streptococcus mutans, Streptococcus pyogenes, Proteus vulgaris, Enterobacter aerogenes, Pseudomonas aeruginosa, Klebsiella pneumoniae (bacteria), Candida albicans, Aspergillus niger and Aspergillus flavus (fungi). The antibiotic activities confirmed effectiveness of plant for treating ailments." @default.
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- W2196337416 date "2015-10-24" @default.
- W2196337416 modified "2023-09-24" @default.
- W2196337416 title "Isolation of Quinone Methides - Tingenone and Pristimerin from the Whole Root of Salacia oliveriana (Celastraceae)" @default.
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