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- W2196350097 abstract "The resurgence of haploidentical donor transplantation over the past decade is a major advance in the field of hematopoietic cell transplantation (HCT). Several platforms have been described, such as ex vivo T-cell depletion techniques with positive-CD34+ selection, ‘mega-dose’ of purified CD34+ cells, or selective depletion of T-cells, and T-cell replete approaches that include use of intensified immune suppression or post-transplant high-dose cyclophosphamide.1, 2, 3 It is safe to say that haploidentical transplantation has become a well-accepted alternative donor source, with several studies reporting survival comparable to umbilical cord blood and matched unrelated donors.4, 5, 6, 7, 8 Ongoing clinical trials such as the BMT CTN 1101 (double cord versus haplo) will further clarify where haploidentical donors factor into the donor selection process." @default.
- W2196350097 created "2016-06-24" @default.
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- W2196350097 date "2015-12-07" @default.
- W2196350097 modified "2023-10-09" @default.
- W2196350097 title "HLA-identical siblings versus haploidentical donors: full match still beats half match" @default.
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- W2196350097 doi "https://doi.org/10.1038/bmt.2015.291" @default.
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