FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2196520558> ?p ?o ?g. }

• W2196520558 endingPage "80" @default.
• W2196520558 startingPage "74" @default.
• W2196520558 abstract "Hepatitis B virus (HBV) dynamics in treated patients can be complex and differ considerably from other viral infections. We analyse dynamics of liver and serum levels of HBV DNA in 24 chronically HBV-infected individuals undergoing 1 year of combination therapy with pegylated interferon alpha and adefovir dipivoxil (ADV), followed by 2 years of ADV monotherapy. Serum viral dynamics differentiated the patients into four response groups dependent on how quickly viremia became undetectable: quickly suppressed (HBV DNA <100 copies/ml within 8 weeks and staying suppressed, GRP1); quickly suppressed but some rebound (<10,000 copies/ml, GRP2); slow decay (GRP3); virological failures (>10,000 copies/ml, GRP4). These groups did not differ before start of therapy by serum HBV DNA (p=0.2), HBsAg (p=0.1), ALT (p=0.4), total HBV DNA within the liver (p=0.08), or cccDNA (p=0.3). Despite very different serum HBV DNA levels after 3 years, there was no statistical difference in total HBV DNA within the liver (p=0.08), nor in cccDNA levels (p=0.1), but HBsAg levels in serum were significantly lower for GRP1 compared to GRP4 (p=0.02). Efficacy in terms of reduction over the 3 years of serum HBV DNA, liver HBV DNA, cccDNA, and ratios of liver HBV DNA to cccDNA were 99.98%, 99.5%, 98.4%, and 83.2% respectively, exhibiting larger antiviral effects in serum than in liver. Over the course of therapy, HBV DNA viremia exhibited large oscillations for some individuals. Mathematical modelling reproduced the dynamics of these diverse groups by assuming a number of viral clones arose that experienced delayed recognition by the antibody response. Large viremia oscillations under therapy suggest sequential outgrowth of viral clones with delayed recognition by the humoral response." @default.
• W2196520558 created "2016-06-24" @default.
• W2196520558 creator A5000271726 @default.
• W2196520558 creator A5002384746 @default.
• W2196520558 creator A5008360976 @default.
• W2196520558 creator A5008902850 @default.
• W2196520558 creator A5070490848 @default.
• W2196520558 creator A5081100749 @default.
• W2196520558 date "2016-02-01" @default.
• W2196520558 modified "2023-10-03" @default.
• W2196520558 title "Variability in long-term hepatitis B virus dynamics under antiviral therapy" @default.
• W2196520558 cites W1424006447 @default.
• W2196520558 cites W1966416075 @default.
• W2196520558 cites W1968184723 @default.
• W2196520558 cites W1969760550 @default.
• W2196520558 cites W1973543793 @default.
• W2196520558 cites W1974721186 @default.
• W2196520558 cites W1991592276 @default.
• W2196520558 cites W1992409693 @default.
• W2196520558 cites W2007835096 @default.
• W2196520558 cites W2007999618 @default.
• W2196520558 cites W2038334617 @default.
• W2196520558 cites W2043987692 @default.
• W2196520558 cites W2045956714 @default.
• W2196520558 cites W2046150771 @default.
• W2196520558 cites W2059560167 @default.
• W2196520558 cites W2075557802 @default.
• W2196520558 cites W2084013582 @default.
• W2196520558 cites W2089153567 @default.
• W2196520558 cites W2096806332 @default.
• W2196520558 cites W2108226840 @default.
• W2196520558 cites W2109848199 @default.
• W2196520558 cites W2115715165 @default.
• W2196520558 cites W2126663612 @default.
• W2196520558 cites W2143501119 @default.
• W2196520558 cites W2169404894 @default.
• W2196520558 cites W2426020403 @default.
• W2196520558 cites W4230991682 @default.
• W2196520558 cites W91492690 @default.
• W2196520558 doi "https://doi.org/10.1016/j.jtbi.2015.12.005" @default.
• W2196520558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26723531" @default.
• W2196520558 hasPublicationYear "2016" @default.
• W2196520558 type Work @default.
• W2196520558 sameAs 2196520558 @default.
• W2196520558 citedByCount "7" @default.
• W2196520558 countsByYear W21965205582016 @default.
• W2196520558 countsByYear W21965205582017 @default.
• W2196520558 countsByYear W21965205582018 @default.
• W2196520558 countsByYear W21965205582019 @default.
• W2196520558 countsByYear W21965205582021 @default.
• W2196520558 crossrefType "journal-article" @default.
• W2196520558 hasAuthorship W2196520558A5000271726 @default.
• W2196520558 hasAuthorship W2196520558A5002384746 @default.
• W2196520558 hasAuthorship W2196520558A5008360976 @default.
• W2196520558 hasAuthorship W2196520558A5008902850 @default.
• W2196520558 hasAuthorship W2196520558A5070490848 @default.
• W2196520558 hasAuthorship W2196520558A5081100749 @default.
• W2196520558 hasConcept C159047783 @default.
• W2196520558 hasConcept C189490182 @default.
• W2196520558 hasConcept C203014093 @default.
• W2196520558 hasConcept C2522874641 @default.
• W2196520558 hasConcept C2776185481 @default.
• W2196520558 hasConcept C2776461080 @default.
• W2196520558 hasConcept C2777410769 @default.
• W2196520558 hasConcept C2777869810 @default.
• W2196520558 hasConcept C2779517838 @default.
• W2196520558 hasConcept C2780040827 @default.
• W2196520558 hasConcept C2780593183 @default.
• W2196520558 hasConcept C3020491458 @default.
• W2196520558 hasConcept C71924100 @default.
• W2196520558 hasConcept C86803240 @default.
• W2196520558 hasConceptScore W2196520558C159047783 @default.
• W2196520558 hasConceptScore W2196520558C189490182 @default.
• W2196520558 hasConceptScore W2196520558C203014093 @default.
• W2196520558 hasConceptScore W2196520558C2522874641 @default.
• W2196520558 hasConceptScore W2196520558C2776185481 @default.
• W2196520558 hasConceptScore W2196520558C2776461080 @default.
• W2196520558 hasConceptScore W2196520558C2777410769 @default.
• W2196520558 hasConceptScore W2196520558C2777869810 @default.
• W2196520558 hasConceptScore W2196520558C2779517838 @default.
• W2196520558 hasConceptScore W2196520558C2780040827 @default.
• W2196520558 hasConceptScore W2196520558C2780593183 @default.
• W2196520558 hasConceptScore W2196520558C3020491458 @default.
• W2196520558 hasConceptScore W2196520558C71924100 @default.
• W2196520558 hasConceptScore W2196520558C86803240 @default.
• W2196520558 hasLocation W21965205581 @default.
• W2196520558 hasLocation W21965205582 @default.
• W2196520558 hasOpenAccess W2196520558 @default.
• W2196520558 hasPrimaryLocation W21965205581 @default.
• W2196520558 hasRelatedWork W1989143809 @default.
• W2196520558 hasRelatedWork W2041886750 @default.
• W2196520558 hasRelatedWork W2088849008 @default.
• W2196520558 hasRelatedWork W2089153567 @default.
• W2196520558 hasRelatedWork W2091886855 @default.
• W2196520558 hasRelatedWork W2196520558 @default.
• W2196520558 hasRelatedWork W2351448447 @default.
• W2196520558 hasRelatedWork W2653435827 @default.
• W2196520558 hasRelatedWork W2766427799 @default.

• next