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- W2196562403 abstract "Receptor-mediated retrograde axonal transport to sensory neurons of the dorsal root ganglia (DRG) has been demonstrated for the neurotrophins, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4), as well as the neuroactive cytokines, ciliary neurotrophic factor (CNTF) and leukemia inhibitory factor (LIF). The receptor-mediated nature of these transport events has been demonstrated by a pharmacological approach. Increased transport of CNTF after peripheral nerve lesion may be an intrinsically programmed cellular mechanism for increasing the accumulation of much needed neurotrophic factors after neuronal damage. Further, injured or otherwise compromised neurons may show a selective responsiveness to neurotrophic factors by virtue of their increased retrograde transport. This is of significance when considering therapeutic intervention with pharmacological doses of neurotrophic factors for peripheral neuropathies. It is necessary to determine how the increased retrograde flow of neurotrophic signals is processed and what molecular mechanisms are operable in the transduction of these retrograde signals." @default.
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- W2196562403 date "1994-01-01" @default.
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- W2196562403 title "Chapter 4 Receptor mediated retrograde axonal transport of neurotrophic factors is increased after peripheral nerve injury" @default.
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- W2196562403 doi "https://doi.org/10.1016/s0079-6123(08)61124-3" @default.
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