FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2196632372> ?p ?o ?g. }

• W2196632372 endingPage "456" @default.
• W2196632372 startingPage "449" @default.
• W2196632372 abstract "The Human immunodeficiency virus type 1 (HIV-1) gp41 membrane proximal external region (MPER) is targeted by broadly neutralizing antibodies (e.g. 2F5, 4E10, Z13e and m66.6), which makes this region a promising target for vaccine design. One strategy to elicit neutralizing antibodies against the MPER epitope is to design peptide immunogens mimicking neutralization structures. To probe 2F5-like neutralizing antibodies, two yeast-displayed antibody libraries from peripheral blood mononuclear cells from a HIV-1 patient were screened against the 2F5 epitope peptide SP62. Two 2F5-like antibodies were identified that specifically recognized SP62. However, these antibodies only weakly neutralized HIV-1 primary isolates. The epitopes recognized by these two 2F5-like antibodies include not only the 2F5 epitope (amino acids (aa) 662–667 in the MPER) but also several other residues (aa 652–655) locating at the N-terminus in SP62. Experimental results suggest that residues of SP62 adjacent to the 2F5 epitope influence the response of broadly neutralizing 2F5-like antibodies in vaccination. Our findings may aid the design of vaccine immunogens and development of therapeutics against HIV-1 infection." @default.
• W2196632372 created "2016-06-24" @default.
• W2196632372 creator A5010867003 @default.
• W2196632372 creator A5023930365 @default.
• W2196632372 creator A5028355034 @default.
• W2196632372 creator A5052787170 @default.
• W2196632372 creator A5066716873 @default.
• W2196632372 creator A5071732035 @default.
• W2196632372 creator A5085352453 @default.
• W2196632372 date "2015-12-01" @default.
• W2196632372 modified "2023-10-16" @default.
• W2196632372 title "N-terminal residues of an HIV-1 gp41 membrane-proximal external region antigen influence broadly neutralizing 2F5-like antibodies" @default.
• W2196632372 cites W150036197 @default.
• W2196632372 cites W1591828451 @default.
• W2196632372 cites W1794879226 @default.
• W2196632372 cites W1842798465 @default.
• W2196632372 cites W1980696330 @default.
• W2196632372 cites W1983124068 @default.
• W2196632372 cites W1990971245 @default.
• W2196632372 cites W199166898 @default.
• W2196632372 cites W1993035689 @default.
• W2196632372 cites W2001335299 @default.
• W2196632372 cites W2018295245 @default.
• W2196632372 cites W2041534144 @default.
• W2196632372 cites W2065654184 @default.
• W2196632372 cites W2077596118 @default.
• W2196632372 cites W2087322499 @default.
• W2196632372 cites W2095910488 @default.
• W2196632372 cites W2102548388 @default.
• W2196632372 cites W2107068362 @default.
• W2196632372 cites W2113597847 @default.
• W2196632372 cites W2113963476 @default.
• W2196632372 cites W2120399100 @default.
• W2196632372 cites W2125231927 @default.
• W2196632372 cites W2133406801 @default.
• W2196632372 cites W2134322675 @default.
• W2196632372 cites W2136225973 @default.
• W2196632372 cites W2154575731 @default.
• W2196632372 cites W2156841733 @default.
• W2196632372 cites W2159376668 @default.
• W2196632372 cites W2159565850 @default.
• W2196632372 cites W2177434887 @default.
• W2196632372 cites W2411581368 @default.
• W2196632372 doi "https://doi.org/10.1007/s12250-015-3664-6" @default.
• W2196632372 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26715302" @default.
• W2196632372 hasPublicationYear "2015" @default.
• W2196632372 type Work @default.
• W2196632372 sameAs 2196632372 @default.
• W2196632372 citedByCount "6" @default.
• W2196632372 countsByYear W21966323722017 @default.
• W2196632372 countsByYear W21966323722018 @default.
• W2196632372 countsByYear W21966323722019 @default.
• W2196632372 countsByYear W21966323722020 @default.
• W2196632372 crossrefType "journal-article" @default.
• W2196632372 hasAuthorship W2196632372A5010867003 @default.
• W2196632372 hasAuthorship W2196632372A5023930365 @default.
• W2196632372 hasAuthorship W2196632372A5028355034 @default.
• W2196632372 hasAuthorship W2196632372A5052787170 @default.
• W2196632372 hasAuthorship W2196632372A5066716873 @default.
• W2196632372 hasAuthorship W2196632372A5071732035 @default.
• W2196632372 hasAuthorship W2196632372A5085352453 @default.
• W2196632372 hasBestOaLocation W21966323721 @default.
• W2196632372 hasConcept C147483822 @default.
• W2196632372 hasConcept C159047783 @default.
• W2196632372 hasConcept C159654299 @default.
• W2196632372 hasConcept C185592680 @default.
• W2196632372 hasConcept C195616568 @default.
• W2196632372 hasConcept C203014093 @default.
• W2196632372 hasConcept C2776258796 @default.
• W2196632372 hasConcept C2779664074 @default.
• W2196632372 hasConcept C3013748606 @default.
• W2196632372 hasConcept C41008148 @default.
• W2196632372 hasConcept C41625074 @default.
• W2196632372 hasConcept C55493867 @default.
• W2196632372 hasConcept C76155785 @default.
• W2196632372 hasConcept C86803240 @default.
• W2196632372 hasConceptScore W2196632372C147483822 @default.
• W2196632372 hasConceptScore W2196632372C159047783 @default.
• W2196632372 hasConceptScore W2196632372C159654299 @default.
• W2196632372 hasConceptScore W2196632372C185592680 @default.
• W2196632372 hasConceptScore W2196632372C195616568 @default.
• W2196632372 hasConceptScore W2196632372C203014093 @default.
• W2196632372 hasConceptScore W2196632372C2776258796 @default.
• W2196632372 hasConceptScore W2196632372C2779664074 @default.
• W2196632372 hasConceptScore W2196632372C3013748606 @default.
• W2196632372 hasConceptScore W2196632372C41008148 @default.
• W2196632372 hasConceptScore W2196632372C41625074 @default.
• W2196632372 hasConceptScore W2196632372C55493867 @default.
• W2196632372 hasConceptScore W2196632372C76155785 @default.
• W2196632372 hasConceptScore W2196632372C86803240 @default.
• W2196632372 hasIssue "6" @default.
• W2196632372 hasLocation W21966323721 @default.
• W2196632372 hasLocation W21966323722 @default.
• W2196632372 hasOpenAccess W2196632372 @default.
• W2196632372 hasPrimaryLocation W21966323721 @default.
• W2196632372 hasRelatedWork W2026020730 @default.
• W2196632372 hasRelatedWork W2032558153 @default.
• W2196632372 hasRelatedWork W2043541068 @default.

• next