FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2196635253> ?p ?o ?g. }

• W2196635253 abstract "Steroids are often combined with local anesthetic (LA) and injected to reduce pain associated with various chronic non-cancer pain (CNCP) complaints. The biological rationale behind injection of a steroid solution is unclear, and it is uncertain whether the addition of steroids offers any additional benefits over injection of LA alone. We propose to conduct a systematic review and meta-analysis to summarize the evidence for using steroids and LA vs. LA alone in the treatment of CNCP. An experienced librarian will perform a comprehensive search of EMBASE, MEDLINE, and the Cochrane Central Registry of Controlled Trials (CENTRAL) databases with search terms for clinical indications, LA, and steroid agents. We will review bibliographies of all relevant published reviews in the last 5 years for additional studies. Eligible trials will be published in English and randomly allocate patients with CNCP to treatment with steroid and LA injection therapy or injection with LA alone. We will use the guidelines published by the Initiative on Methods, Measurement, and Pain Assessment in Clinical Trials (IMMPACT) to inform the outcomes that we collect and present. Teams of reviewers will independently and in duplicate assess trial eligibility, abstract data, and assess risk of bias among eligible trials. We will prioritize intention to treat analysis and, when possible, pool outcomes across trials using random effects models. We will report our findings as risk differences, weighted mean differences, or standardized mean differences for individual outcomes. Further, to ensure interpretability of our results, we will present risk differences and measures of relative effect for pain reduction based on anchor-based minimally important clinical differences. We will conduct a priori defined subgroup analyses and use the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) system to evaluate the certainty of the evidence on an outcome-by-outcome basis. Our review will evaluate both the effectiveness and the adverse events associated with steroid plus LA vs. LA alone for CNCP, evaluate the quality of the evidence using the GRADE approach, and prioritize patient-important outcomes guided by IMMPACT recommendations. Our results will facilitate evidence-based management of patients with chronic non-cancer pain and identify key areas for future research. PROSPERO CRD42015020614" @default.
• W2196635253 created "2016-06-24" @default.
• W2196635253 creator A5000519200 @default.
• W2196635253 creator A5000654491 @default.
• W2196635253 creator A5017471824 @default.
• W2196635253 creator A5024152253 @default.
• W2196635253 creator A5029801001 @default.
• W2196635253 creator A5036745525 @default.
• W2196635253 creator A5063394859 @default.
• W2196635253 creator A5069929663 @default.
• W2196635253 creator A5082714626 @default.
• W2196635253 creator A5088020127 @default.
• W2196635253 date "2016-02-01" @default.
• W2196635253 modified "2023-10-18" @default.
• W2196635253 title "Local anesthetic injections with or without steroid for chronic non-cancer pain: a protocol for a systematic review and meta-analysis of randomized controlled trials" @default.
• W2196635253 cites W108376642 @default.
• W2196635253 cites W111371916 @default.
• W2196635253 cites W136077900 @default.
• W2196635253 cites W137900692 @default.
• W2196635253 cites W1444168786 @default.
• W2196635253 cites W1508800778 @default.
• W2196635253 cites W1530955749 @default.
• W2196635253 cites W1532685410 @default.
• W2196635253 cites W1659853421 @default.
• W2196635253 cites W181796427 @default.
• W2196635253 cites W1818495483 @default.
• W2196635253 cites W1843875225 @default.
• W2196635253 cites W1924732381 @default.
• W2196635253 cites W192909 @default.
• W2196635253 cites W1935436718 @default.
• W2196635253 cites W1937485064 @default.
• W2196635253 cites W1942192054 @default.
• W2196635253 cites W1963854579 @default.
• W2196635253 cites W1964228822 @default.
• W2196635253 cites W1974871673 @default.
• W2196635253 cites W1974928391 @default.
• W2196635253 cites W1981097272 @default.
• W2196635253 cites W1983714352 @default.
• W2196635253 cites W1984423812 @default.
• W2196635253 cites W1993520198 @default.
• W2196635253 cites W1994405178 @default.
• W2196635253 cites W1997577305 @default.
• W2196635253 cites W2008941884 @default.
• W2196635253 cites W2012830786 @default.
• W2196635253 cites W201442124 @default.
• W2196635253 cites W2015859642 @default.
• W2196635253 cites W2015938598 @default.
• W2196635253 cites W2017778083 @default.
• W2196635253 cites W2018048562 @default.
• W2196635253 cites W2018638145 @default.
• W2196635253 cites W2020576103 @default.
• W2196635253 cites W2022040927 @default.
• W2196635253 cites W2029662381 @default.
• W2196635253 cites W2030641663 @default.
• W2196635253 cites W2032160051 @default.
• W2196635253 cites W2033121188 @default.
• W2196635253 cites W2037097193 @default.
• W2196635253 cites W2043564581 @default.
• W2196635253 cites W2045594606 @default.
• W2196635253 cites W2045861753 @default.
• W2196635253 cites W2047901811 @default.
• W2196635253 cites W2048105386 @default.
• W2196635253 cites W2050889717 @default.
• W2196635253 cites W2051522425 @default.
• W2196635253 cites W2054036955 @default.
• W2196635253 cites W2054227310 @default.
• W2196635253 cites W2054384899 @default.
• W2196635253 cites W2055953531 @default.
• W2196635253 cites W2057340920 @default.
• W2196635253 cites W2058297570 @default.
• W2196635253 cites W2063248446 @default.
• W2196635253 cites W2066378123 @default.
• W2196635253 cites W2067331418 @default.
• W2196635253 cites W2068011806 @default.
• W2196635253 cites W2071042968 @default.
• W2196635253 cites W2074669792 @default.
• W2196635253 cites W2075048005 @default.
• W2196635253 cites W2075069948 @default.
• W2196635253 cites W2075599327 @default.
• W2196635253 cites W2076879633 @default.
• W2196635253 cites W2077029183 @default.
• W2196635253 cites W2077685376 @default.
• W2196635253 cites W2078173913 @default.
• W2196635253 cites W2081491846 @default.
• W2196635253 cites W2083815143 @default.
• W2196635253 cites W2085544937 @default.
• W2196635253 cites W2091636526 @default.
• W2196635253 cites W2091734353 @default.
• W2196635253 cites W2099901505 @default.
• W2196635253 cites W2100841075 @default.
• W2196635253 cites W2100889180 @default.
• W2196635253 cites W2105352739 @default.
• W2196635253 cites W2111664065 @default.
• W2196635253 cites W2116255049 @default.
• W2196635253 cites W2121393149 @default.
• W2196635253 cites W2121999286 @default.
• W2196635253 cites W2124167284 @default.
• W2196635253 cites W2124345737 @default.
• W2196635253 cites W2126990938 @default.
• W2196635253 cites W2129587581 @default.

• next