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- W2197148295 endingPage "31" @default.
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- W2197148295 abstract "Diabetes mellitus is a chronic metabolic disorder with a high prevalence worldwide. Animal models of diabetes represent an important tool in diabetes investigation that helps us to avoid unnecessary and ethically challenging studies in human subjects, as well as to obtain a comprehensive scientific viewpoint of this disease. Although there are several methods through which diabetes can be induced, chemical methods of alloxan- and streptozotocin-induced diabetes represent the most important and highly preferable experimental models for this pathological condition. Therefore, the aim of this article was to review the current knowledge related to quoted models of diabetes, including to this point available information about mechanism of action, particular time- and dose-dependent protocols, frequent problems, as well as major limitations linked to laboratory application of alloxan and sterptozotocin in inducing diabetes. Given that diabetes is known to be closely associated with serious health consequences it is of fundamental importance that current animal models for induction of diabetes should be continuously upgraded in order to improve overall prevention, diagnosis and treatment of this pathological condition." @default.
- W2197148295 created "2016-06-24" @default.
- W2197148295 creator A5027359935 @default.
- W2197148295 creator A5054661711 @default.
- W2197148295 creator A5074980595 @default.
- W2197148295 date "2016-03-01" @default.
- W2197148295 modified "2023-10-12" @default.
- W2197148295 title "Experimental diabetes induced by alloxan and streptozotocin: The current state of the art" @default.
- W2197148295 cites W1019169857 @default.
- W2197148295 cites W111158469 @default.
- W2197148295 cites W1493113918 @default.
- W2197148295 cites W1499012478 @default.
- W2197148295 cites W1507426115 @default.
- W2197148295 cites W1516436527 @default.
- W2197148295 cites W1535873634 @default.
- W2197148295 cites W1541897964 @default.
- W2197148295 cites W1544719142 @default.
- W2197148295 cites W1573634888 @default.
- W2197148295 cites W1592649636 @default.
- W2197148295 cites W1847367967 @default.
- W2197148295 cites W1865758164 @default.
- W2197148295 cites W1881787419 @default.
- W2197148295 cites W1895973721 @default.
- W2197148295 cites W1913230283 @default.
- W2197148295 cites W1950404040 @default.
- W2197148295 cites W1965207348 @default.
- W2197148295 cites W1967706329 @default.
- W2197148295 cites W1967977416 @default.
- W2197148295 cites W1973631125 @default.
- W2197148295 cites W1973709977 @default.
- W2197148295 cites W1975536395 @default.
- W2197148295 cites W1975636506 @default.
- W2197148295 cites W1975760825 @default.
- W2197148295 cites W1975820990 @default.
- W2197148295 cites W1976439535 @default.
- W2197148295 cites W1976873226 @default.
- W2197148295 cites W1979855583 @default.
- W2197148295 cites W1980196380 @default.
- W2197148295 cites W1981418790 @default.
- W2197148295 cites W1982371325 @default.
- W2197148295 cites W1983746471 @default.
- W2197148295 cites W1985332518 @default.
- W2197148295 cites W1985743555 @default.
- W2197148295 cites W1988760657 @default.
- W2197148295 cites W1990898321 @default.
- W2197148295 cites W1994114471 @default.
- W2197148295 cites W1994737024 @default.
- W2197148295 cites W1994928244 @default.
- W2197148295 cites W1995341804 @default.
- W2197148295 cites W1998401813 @default.
- W2197148295 cites W1998767886 @default.
- W2197148295 cites W2000157637 @default.
- W2197148295 cites W2002082805 @default.
- W2197148295 cites W2005802877 @default.
- W2197148295 cites W2006788286 @default.
- W2197148295 cites W2010086282 @default.
- W2197148295 cites W2011299231 @default.
- W2197148295 cites W2012676956 @default.
- W2197148295 cites W2013121339 @default.
- W2197148295 cites W2013401521 @default.
- W2197148295 cites W2015001567 @default.
- W2197148295 cites W2015482067 @default.
- W2197148295 cites W2015704370 @default.
- W2197148295 cites W2015881389 @default.
- W2197148295 cites W2017804617 @default.
- W2197148295 cites W2018318979 @default.
- W2197148295 cites W2021549782 @default.
- W2197148295 cites W2022271344 @default.
- W2197148295 cites W2024059437 @default.
- W2197148295 cites W2024300266 @default.
- W2197148295 cites W2028475901 @default.
- W2197148295 cites W2029364037 @default.
- W2197148295 cites W2030370547 @default.
- W2197148295 cites W2031149113 @default.
- W2197148295 cites W2031525264 @default.
- W2197148295 cites W2032371813 @default.
- W2197148295 cites W2035954089 @default.
- W2197148295 cites W2037742489 @default.
- W2197148295 cites W2038018821 @default.
- W2197148295 cites W2038374779 @default.
- W2197148295 cites W2039695803 @default.
- W2197148295 cites W2039762060 @default.
- W2197148295 cites W2040267509 @default.
- W2197148295 cites W2041148626 @default.
- W2197148295 cites W2042293867 @default.
- W2197148295 cites W2043238274 @default.
- W2197148295 cites W2044337263 @default.
- W2197148295 cites W2044942299 @default.
- W2197148295 cites W2045847046 @default.
- W2197148295 cites W2046644382 @default.
- W2197148295 cites W2048798398 @default.
- W2197148295 cites W2049073771 @default.
- W2197148295 cites W2050178835 @default.
- W2197148295 cites W2050192181 @default.
- W2197148295 cites W2050480355 @default.
- W2197148295 cites W2051523080 @default.
- W2197148295 cites W2051740389 @default.
- W2197148295 cites W2051947850 @default.