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- W2197348281 abstract "THE ROLE OF α3β4* SUBTYPE OF NICOTINIC ACETYLCHOLINE RECEPTORS IN REVERSING OPIOID-INDUCED CONSTIPATION IN MICE By Aravind Reddy Gade, MS A Dissertation submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy at Virginia Commonwealth University. Virginia Commonwealth University, 2015 Major Director: Hamid I. Akbarali, Ph.D. Professor, Department of Pharmacology and Toxicology Opioids are excellent pain relievers. A major side-effect of chronic opioid treatment is constipation whereas withdrawal following chronic exposure leads to diarrhea and increased gastrointestinal motility. These effects of chronic opioids are mediated by μ-opioid receptors expressed on enteric neurons. Previous studies have shown that chronic opioids enhance sensitivity to nicotine in the gastrointestinal tract. This suggested that prokinetic effects of nicotine mediated through the activation of nicotinic acetylcholine receptors (nAChRs) may be useful in reversing opioid-induced constipation. The goal of this dissertation was to investigate the nAChR subtype expressed on enteric neurons and their role in reversing opioid-induced constipation. The effect of nicotine on small intestinal transit and fecal pellet output were determined in-vivo in morphine-pelleted mice" @default.
- W2197348281 created "2016-06-24" @default.
- W2197348281 creator A5052315987 @default.
- W2197348281 date "2015-01-01" @default.
- W2197348281 modified "2023-09-23" @default.
- W2197348281 title "The role of alpha3beta4* subtype of nicotinic acetylcholine receptors in reversing opioid-induced constipation in mice" @default.
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- W2197348281 doi "https://doi.org/10.25772/bqjg-d471" @default.
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