FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2197389618> ?p ?o ?g. }

• W2197389618 endingPage "1022" @default.
• W2197389618 startingPage "1015" @default.
• W2197389618 abstract "Cutaneous acetylcholine (ACh)-mediated dilation is commonly used to assess microvascular function, but the mechanisms of dilation are poorly understood. Depending on dose and method of administration, nitric oxide (NO) and prostanoids are involved to varying extents and the roles of endothelial-derived hyperpolarizing factors (EDHFs) are unclear. In the present study, five incremental doses of ACh (0.01-100 mM) were delivered either as a 1-min bolus ( protocol 1, n = 12) or as a ≥20-min continuous infusion ( protocol 2, n = 10) via microdialysis fibers infused with 1) lactated Ringer, 2) tetraethylammonium (TEA) [a calcium-activated potassium channel (K Ca ) and EDHF inhibitor], 3) L-NNA+ketorolac [NO synthase (NOS) and cyclooxygenase (COX) inhibitors], and 4) TEA+L-NNA+Ketorolac. The hyperemic response was characterized as peak and area under the curve (AUC) cutaneous vascular conductance (CVC) for bolus infusions or plateau CVC for continuous infusions, and reported as %maximal CVC. In protocol 1, TEA, alone and combined with NOS+COX inhibition, attenuated peak CVC (100 mM Ringer 59 ± 6% vs. TEA 43 ± 5%, P < 0.05; L-NNA+ketorolac 35 ± 4% vs. TEA+L-NNA+ketorolac 25 ± 4%, P < 0.05) and AUC (Ringer 25,414 ± 3,528 vs. TEA 21,403 ± 3,416%·s, P < 0.05; L-NNA+ketorolac 25,628 ± 3,828% . s vs. TEA+L-NNA+ketorolac 20,772 ± 3,711%·s, P < 0.05), although these effects were only significant at the highest dose of ACh. At lower doses, TEA lengthened the total time of the hyperemic response (10 mM Ringer 609 ± 78 s vs. TEA 860 ± 67 s, P < 0.05). In protocol 2, TEA alone did not affect plateau CVC, but attenuated plateau in combination with NOS+COX inhibition (100 mM 50.4 ± 6.6% vs. 30.9 ± 6.3%, P < 0.05). Therefore, EDHFs contribute to cutaneous ACh-mediated dilation, but their relative contribution is altered by the dose and infusion procedure." @default.
• W2197389618 created "2016-06-24" @default.
• W2197389618 creator A5039262499 @default.
• W2197389618 creator A5049874519 @default.
• W2197389618 creator A5077010538 @default.
• W2197389618 date "2015-11-01" @default.
• W2197389618 modified "2023-10-14" @default.
• W2197389618 title "Endothelial-derived hyperpolarization contributes to acetylcholine-mediated vasodilation in human skin in a dose-dependent manner" @default.
• W2197389618 cites W1494015354 @default.
• W2197389618 cites W1512208301 @default.
• W2197389618 cites W1543858055 @default.
• W2197389618 cites W1546150314 @default.
• W2197389618 cites W1745475402 @default.
• W2197389618 cites W1753089048 @default.
• W2197389618 cites W1901856024 @default.
• W2197389618 cites W1962948334 @default.
• W2197389618 cites W1966448013 @default.
• W2197389618 cites W1972099526 @default.
• W2197389618 cites W1976439756 @default.
• W2197389618 cites W1993321878 @default.
• W2197389618 cites W1995115564 @default.
• W2197389618 cites W1995410621 @default.
• W2197389618 cites W2001644667 @default.
• W2197389618 cites W2006164532 @default.
• W2197389618 cites W2009356635 @default.
• W2197389618 cites W2012185701 @default.
• W2197389618 cites W2013226898 @default.
• W2197389618 cites W2014152566 @default.
• W2197389618 cites W2015407072 @default.
• W2197389618 cites W2018783875 @default.
• W2197389618 cites W2026499114 @default.
• W2197389618 cites W2041001842 @default.
• W2197389618 cites W2045349934 @default.
• W2197389618 cites W2048148521 @default.
• W2197389618 cites W2061846540 @default.
• W2197389618 cites W2064489455 @default.
• W2197389618 cites W2067696654 @default.
• W2197389618 cites W2069174503 @default.
• W2197389618 cites W2097830293 @default.
• W2197389618 cites W2099439022 @default.
• W2197389618 cites W2107314742 @default.
• W2197389618 cites W2112396940 @default.
• W2197389618 cites W2115563064 @default.
• W2197389618 cites W2118445762 @default.
• W2197389618 cites W2126017233 @default.
• W2197389618 cites W2128705796 @default.
• W2197389618 cites W2128986918 @default.
• W2197389618 cites W2129668596 @default.
• W2197389618 cites W2129892668 @default.
• W2197389618 cites W2130336900 @default.
• W2197389618 cites W2131236495 @default.
• W2197389618 cites W2143200013 @default.
• W2197389618 cites W2143502990 @default.
• W2197389618 cites W2164947554 @default.
• W2197389618 cites W2166928530 @default.
• W2197389618 cites W2166936192 @default.
• W2197389618 cites W2167393076 @default.
• W2197389618 cites W2334159027 @default.
• W2197389618 cites W2408672930 @default.
• W2197389618 cites W2410787202 @default.
• W2197389618 doi "https://doi.org/10.1152/japplphysiol.00201.2015" @default.
• W2197389618 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4628993" @default.
• W2197389618 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26384409" @default.
• W2197389618 hasPublicationYear "2015" @default.
• W2197389618 type Work @default.
• W2197389618 sameAs 2197389618 @default.
• W2197389618 citedByCount "28" @default.
• W2197389618 countsByYear W21973896182015 @default.
• W2197389618 countsByYear W21973896182016 @default.
• W2197389618 countsByYear W21973896182017 @default.
• W2197389618 countsByYear W21973896182018 @default.
• W2197389618 countsByYear W21973896182019 @default.
• W2197389618 countsByYear W21973896182020 @default.
• W2197389618 countsByYear W21973896182021 @default.
• W2197389618 countsByYear W21973896182022 @default.
• W2197389618 countsByYear W21973896182023 @default.
• W2197389618 crossrefType "journal-article" @default.
• W2197389618 hasAuthorship W2197389618A5039262499 @default.
• W2197389618 hasAuthorship W2197389618A5049874519 @default.
• W2197389618 hasAuthorship W2197389618A5077010538 @default.
• W2197389618 hasBestOaLocation W21973896182 @default.
• W2197389618 hasConcept C120770815 @default.
• W2197389618 hasConcept C134018914 @default.
• W2197389618 hasConcept C178790620 @default.
• W2197389618 hasConcept C181199279 @default.
• W2197389618 hasConcept C185592680 @default.
• W2197389618 hasConcept C2775910092 @default.
• W2197389618 hasConcept C2778446825 @default.
• W2197389618 hasConcept C2779689624 @default.
• W2197389618 hasConcept C2780820201 @default.
• W2197389618 hasConcept C2781295685 @default.
• W2197389618 hasConcept C42219234 @default.
• W2197389618 hasConcept C50156730 @default.
• W2197389618 hasConcept C517785266 @default.
• W2197389618 hasConcept C519581460 @default.
• W2197389618 hasConcept C529278444 @default.
• W2197389618 hasConcept C55493867 @default.
• W2197389618 hasConcept C71924100 @default.

• next