FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2197454865> ?p ?o ?g. }

• W2197454865 endingPage "475" @default.
• W2197454865 startingPage "465" @default.
• W2197454865 abstract "The contribution of human neutrophils to the protection against fungal infections by Aspergillus fumigatus is essential but not fully understood. Whereas healthy people can inhale spores of A. fumigatus without developing disease, neutropenic patients and those receiving immunosuppressive drugs have a higher incidence of invasive fungal infections. To study the role of neutrophils in protection against A. fumigatus infections, we developed an in vitro assay in which the interactions between human neutrophils and A. fumigatus were observed in real time, at single-cell resolution, in precisely controlled conditions. We measured the outcomes of neutrophil-fungus interactions and found that human neutrophils have a limited ability to migrate toward A. fumigatus and block the growth of A. fumigatus conidia (proportion with growth blocked, 69%). The blocking ability of human neutrophils increased to 85.1% when they were stimulated by uniform concentrations of fMLP and was enhanced further, to 99.4%, in the presence of chemoattractant gradients. Neutrophils from patients receiving immunosuppressive treatment after transplantation were less effective against the fungus than those from healthy donors, and broader heterogeneity exists between patients, compared with healthy individuals. Further studies using this microfluidic platform will help understand the relevance of innate immune deficiencies responsible for the higher risk of fungal infections in patients with immunosuppressive disease." @default.
• W2197454865 created "2016-06-24" @default.
• W2197454865 creator A5021460440 @default.
• W2197454865 creator A5042617889 @default.
• W2197454865 creator A5064290143 @default.
• W2197454865 creator A5066059486 @default.
• W2197454865 creator A5067505926 @default.
• W2197454865 creator A5072837552 @default.
• W2197454865 creator A5076825767 @default.
• W2197454865 creator A5087468269 @default.
• W2197454865 date "2015-08-12" @default.
• W2197454865 modified "2023-10-16" @default.
• W2197454865 title "Human Neutrophils Are Primed by Chemoattractant Gradients for Blocking the Growth of<i>Aspergillus fumigatus</i>" @default.
• W2197454865 cites W1916951787 @default.
• W2197454865 cites W1966092471 @default.
• W2197454865 cites W1967781603 @default.
• W2197454865 cites W1979790110 @default.
• W2197454865 cites W1979878015 @default.
• W2197454865 cites W1988618549 @default.
• W2197454865 cites W2002836781 @default.
• W2197454865 cites W2004178128 @default.
• W2197454865 cites W2008854979 @default.
• W2197454865 cites W2013172275 @default.
• W2197454865 cites W2021009407 @default.
• W2197454865 cites W2036903343 @default.
• W2197454865 cites W2050513753 @default.
• W2197454865 cites W2051415060 @default.
• W2197454865 cites W2054605333 @default.
• W2197454865 cites W2061652403 @default.
• W2197454865 cites W2084241068 @default.
• W2197454865 cites W2105678060 @default.
• W2197454865 cites W2114162558 @default.
• W2197454865 cites W2119645560 @default.
• W2197454865 cites W2126554260 @default.
• W2197454865 cites W2127386412 @default.
• W2197454865 cites W2144671759 @default.
• W2197454865 cites W2144728423 @default.
• W2197454865 cites W2152961129 @default.
• W2197454865 cites W2162074188 @default.
• W2197454865 cites W2162184832 @default.
• W2197454865 cites W2166909888 @default.
• W2197454865 cites W2171595787 @default.
• W2197454865 cites W2320278097 @default.
• W2197454865 cites W2409624505 @default.
• W2197454865 cites W2415281123 @default.
• W2197454865 cites W2520163263 @default.
• W2197454865 cites W4206004587 @default.
• W2197454865 cites W4211087629 @default.
• W2197454865 cites W4235641583 @default.
• W2197454865 cites W4254102874 @default.
• W2197454865 doi "https://doi.org/10.1093/infdis/jiv419" @default.
• W2197454865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4704668" @default.
• W2197454865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26272935" @default.
• W2197454865 hasPublicationYear "2015" @default.
• W2197454865 type Work @default.
• W2197454865 sameAs 2197454865 @default.
• W2197454865 citedByCount "28" @default.
• W2197454865 countsByYear W21974548652016 @default.
• W2197454865 countsByYear W21974548652017 @default.
• W2197454865 countsByYear W21974548652018 @default.
• W2197454865 countsByYear W21974548652019 @default.
• W2197454865 countsByYear W21974548652020 @default.
• W2197454865 countsByYear W21974548652021 @default.
• W2197454865 countsByYear W21974548652022 @default.
• W2197454865 countsByYear W21974548652023 @default.
• W2197454865 crossrefType "journal-article" @default.
• W2197454865 hasAuthorship W2197454865A5021460440 @default.
• W2197454865 hasAuthorship W2197454865A5042617889 @default.
• W2197454865 hasAuthorship W2197454865A5064290143 @default.
• W2197454865 hasAuthorship W2197454865A5066059486 @default.
• W2197454865 hasAuthorship W2197454865A5067505926 @default.
• W2197454865 hasAuthorship W2197454865A5072837552 @default.
• W2197454865 hasAuthorship W2197454865A5076825767 @default.
• W2197454865 hasAuthorship W2197454865A5087468269 @default.
• W2197454865 hasBestOaLocation W21974548651 @default.
• W2197454865 hasConcept C136449434 @default.
• W2197454865 hasConcept C170493617 @default.
• W2197454865 hasConcept C202751555 @default.
• W2197454865 hasConcept C203014093 @default.
• W2197454865 hasConcept C2776391196 @default.
• W2197454865 hasConcept C2779175654 @default.
• W2197454865 hasConcept C2779787849 @default.
• W2197454865 hasConcept C54166955 @default.
• W2197454865 hasConcept C55493867 @default.
• W2197454865 hasConcept C86803240 @default.
• W2197454865 hasConcept C8891405 @default.
• W2197454865 hasConcept C89423630 @default.
• W2197454865 hasConceptScore W2197454865C136449434 @default.
• W2197454865 hasConceptScore W2197454865C170493617 @default.
• W2197454865 hasConceptScore W2197454865C202751555 @default.
• W2197454865 hasConceptScore W2197454865C203014093 @default.
• W2197454865 hasConceptScore W2197454865C2776391196 @default.
• W2197454865 hasConceptScore W2197454865C2779175654 @default.
• W2197454865 hasConceptScore W2197454865C2779787849 @default.
• W2197454865 hasConceptScore W2197454865C54166955 @default.
• W2197454865 hasConceptScore W2197454865C55493867 @default.
• W2197454865 hasConceptScore W2197454865C86803240 @default.
• W2197454865 hasConceptScore W2197454865C8891405 @default.

• next