Matches in SemOpenAlex for { <https://semopenalex.org/work/W2197888933> ?p ?o ?g. }
- W2197888933 endingPage "44" @default.
- W2197888933 startingPage "33" @default.
- W2197888933 abstract "Abstract Vitamin E is group of natural antioxidants comprised of tocopherols and tocotrienols. Structural analogs of vitamin E exhibit selective antiproliferative activity that has been intensively studied over the last decade in various cancer cells (MCF-7, MDA-MB-231, LNCaP, PC-3, A549, K562, Jurkat). 2D- and 3D-QSAR studies were applied on a series of 30 derivatives of tocopherols, tocotrienols and chromane with antiproliferative activity in MCF-7 breast cancer cell line. All molecular structures were previously optimized using ab initio Hartree-Fock/3-21 G method. Partial Least Square Regression analysis was used to develop 2D- and 3D-QSAR model. Statistical parameters: R2 = 0.798, Q2 = 0.772, R2pred = 0.685 (2D-QSAR) and R2 = 0.960, Q2 = 0.830, R2pred = 0.649 (3D-QSAR) indicated on good predictive power of both models. Based on the applied QSAR studies were identified molecular determinant with the greatest influence on the antiproliferative activity and designed novel compounds with enhanced activity against MCF-7 breast cancer cells." @default.
- W2197888933 created "2016-06-24" @default.
- W2197888933 creator A5013717837 @default.
- W2197888933 creator A5017866760 @default.
- W2197888933 creator A5044944147 @default.
- W2197888933 creator A5050801978 @default.
- W2197888933 creator A5074835497 @default.
- W2197888933 date "2016-02-01" @default.
- W2197888933 modified "2023-09-25" @default.
- W2197888933 title "QSAR studies and design of new analogs of vitamin E with enhanced antiproliferative activity on MCF-7 breast cancer cells" @default.
- W2197888933 cites W1528831599 @default.
- W2197888933 cites W1570912112 @default.
- W2197888933 cites W1780914609 @default.
- W2197888933 cites W1970212349 @default.
- W2197888933 cites W1974778190 @default.
- W2197888933 cites W1993871655 @default.
- W2197888933 cites W1996732400 @default.
- W2197888933 cites W2005464759 @default.
- W2197888933 cites W2009221662 @default.
- W2197888933 cites W2011079470 @default.
- W2197888933 cites W2011580004 @default.
- W2197888933 cites W2011795370 @default.
- W2197888933 cites W2015516594 @default.
- W2197888933 cites W2016440321 @default.
- W2197888933 cites W2020994403 @default.
- W2197888933 cites W2028426028 @default.
- W2197888933 cites W2030436572 @default.
- W2197888933 cites W2045406957 @default.
- W2197888933 cites W2047270735 @default.
- W2197888933 cites W2048000631 @default.
- W2197888933 cites W2052084403 @default.
- W2197888933 cites W2055776987 @default.
- W2197888933 cites W2066420346 @default.
- W2197888933 cites W2071993071 @default.
- W2197888933 cites W2076018148 @default.
- W2197888933 cites W2077338331 @default.
- W2197888933 cites W2079783670 @default.
- W2197888933 cites W2086190989 @default.
- W2197888933 cites W2087661061 @default.
- W2197888933 cites W2091193109 @default.
- W2197888933 cites W2108619906 @default.
- W2197888933 cites W2115420718 @default.
- W2197888933 cites W2117195140 @default.
- W2197888933 cites W2118868944 @default.
- W2197888933 cites W2127336290 @default.
- W2197888933 cites W2128245586 @default.
- W2197888933 cites W2129352477 @default.
- W2197888933 cites W2139862399 @default.
- W2197888933 cites W2153127376 @default.
- W2197888933 cites W2155358697 @default.
- W2197888933 cites W2166070864 @default.
- W2197888933 cites W2313909535 @default.
- W2197888933 cites W2330060845 @default.
- W2197888933 cites W4244209983 @default.
- W2197888933 cites W2072277274 @default.
- W2197888933 doi "https://doi.org/10.1016/j.jtice.2015.07.019" @default.
- W2197888933 hasPublicationYear "2016" @default.
- W2197888933 type Work @default.
- W2197888933 sameAs 2197888933 @default.
- W2197888933 citedByCount "20" @default.
- W2197888933 countsByYear W21978889332016 @default.
- W2197888933 countsByYear W21978889332017 @default.
- W2197888933 countsByYear W21978889332019 @default.
- W2197888933 countsByYear W21978889332020 @default.
- W2197888933 countsByYear W21978889332021 @default.
- W2197888933 countsByYear W21978889332022 @default.
- W2197888933 crossrefType "journal-article" @default.
- W2197888933 hasAuthorship W2197888933A5013717837 @default.
- W2197888933 hasAuthorship W2197888933A5017866760 @default.
- W2197888933 hasAuthorship W2197888933A5044944147 @default.
- W2197888933 hasAuthorship W2197888933A5050801978 @default.
- W2197888933 hasAuthorship W2197888933A5074835497 @default.
- W2197888933 hasConcept C109541995 @default.
- W2197888933 hasConcept C121608353 @default.
- W2197888933 hasConcept C126322002 @default.
- W2197888933 hasConcept C164126121 @default.
- W2197888933 hasConcept C185592680 @default.
- W2197888933 hasConcept C2994423619 @default.
- W2197888933 hasConcept C530470458 @default.
- W2197888933 hasConcept C55493867 @default.
- W2197888933 hasConcept C71240020 @default.
- W2197888933 hasConcept C71924100 @default.
- W2197888933 hasConceptScore W2197888933C109541995 @default.
- W2197888933 hasConceptScore W2197888933C121608353 @default.
- W2197888933 hasConceptScore W2197888933C126322002 @default.
- W2197888933 hasConceptScore W2197888933C164126121 @default.
- W2197888933 hasConceptScore W2197888933C185592680 @default.
- W2197888933 hasConceptScore W2197888933C2994423619 @default.
- W2197888933 hasConceptScore W2197888933C530470458 @default.
- W2197888933 hasConceptScore W2197888933C55493867 @default.
- W2197888933 hasConceptScore W2197888933C71240020 @default.
- W2197888933 hasConceptScore W2197888933C71924100 @default.
- W2197888933 hasFunder F4320322729 @default.
- W2197888933 hasLocation W21978889331 @default.
- W2197888933 hasOpenAccess W2197888933 @default.
- W2197888933 hasPrimaryLocation W21978889331 @default.
- W2197888933 hasRelatedWork W2011154259 @default.
- W2197888933 hasRelatedWork W2076386220 @default.