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• W2198351935 abstract "Refractometers are commonly used to determine urine specific gravity (SG) in the assessment of hydration status and urine specimen validity testing. Few comprehensive performance evaluations are available demonstrating refractometer capability from a clinical laboratory perspective. The objective of this study was therefore to conduct an analytical validation of a handheld digital refractometer used for human urine SG testing.A MISCO Palm Abbe™ refractometer was used for all experiments, including device familiarization, carryover, precision, accuracy, linearity, analytical sensitivity, evaluation of potential substances which contribute to SG (i.e. “interference”), and reference interval evaluation. A manual refractometer, urine osmometer, and a solute score (sum of urine chloride, creatinine, glucose, potassium, sodium, total protein, and urea nitrogen; all in mg/dL) were used as comparative methods for accuracy assessment.Significant carryover was not observed. A wash step was still included as good laboratory practice. Low imprecision (%CV, <0.01) was demonstrated using low and high QC material. Accuracy studies showed strong correlation to manual refractometry. Linear correlation was also demonstrated between SG, osmolality, and solute score. Linearity of Palm Abbe performance was verified with observed error of ≤0.1%. Increases in SG were observed with increasing concentrations of albumin, creatinine, glucose, hemoglobin, sodium chloride, and urea. Transference of a previously published urine SG reference interval of 1.0020–1.0300 was validated.The Palm Abbe digital refractometer was a fast, simple, and accurate way to measure urine SG. Analytical validity was confirmed by the present experiments." @default.
• W2198351935 created "2016-06-24" @default.
• W2198351935 creator A5061656670 @default.
• W2198351935 date "1956-01-01" @default.
• W2198351935 modified "2023-09-27" @default.
• W2198351935 title "Materials for the Biophysical and Biochemical Study of Cell Division" @default.
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• W2198351935 doi "https://doi.org/10.1016/b978-1-4832-3110-5.50007-8" @default.
• W2198351935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/13354509" @default.
• W2198351935 hasPublicationYear "1956" @default.
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