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- W2198507924 endingPage "145" @default.
- W2198507924 startingPage "130" @default.
- W2198507924 abstract "AMP-activated protein kinase (AMPK) has consequently been evolved in eukaryotic cells as an ancient metabolic enzyme with the ability to sense compromised availability of cellular energy resulting from various physiological or pathological stimuli. This chapter highlights recent advances in understanding the role of AMPK activity in the brain and its impact on neuronal metabolism, its neuron-specific (“neuronlike”) functions, its role in neuronal cell death and neurodegeneration, and its role as a potential therapeutic target. Most of in vivo studies have shown deleterious effects of AMPK in ischemic brain. However, a study by Kuramoto et al. has described AMPK as initiating a neuroprotective signaling cascade. Both an increase in our knowledge of the diverse substrates of AMPK, as well as a better temporal and spatial analysis of AMPK signaling effects will likely deliver new key insights into the role of AMPK in neurodevelopment, neuronal physiology, and neuronal injury." @default.
- W2198507924 created "2016-06-24" @default.
- W2198507924 creator A5058995380 @default.
- W2198507924 creator A5061169544 @default.
- W2198507924 creator A5066581807 @default.
- W2198507924 date "2015-09-25" @default.
- W2198507924 modified "2023-09-27" @default.
- W2198507924 title "AMP-Activated Protein Kinase (AMPK) as a Cellular Energy Sensor and Therapeutic Target for Neuroprotection" @default.
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