Matches in SemOpenAlex for { <https://semopenalex.org/work/W2198552972> ?p ?o ?g. }
Showing items 1 to 77 of
77
with 100 items per page.
- W2198552972 endingPage "506" @default.
- W2198552972 startingPage "491" @default.
- W2198552972 abstract "Alum-precipitated keyhole limpet hemocyanin (KLH) and polymerized human serum albumin (HSA) were injected into the hind foot pads of rabbits. Many months later the popliteal lymph nodes were removed and cell cultures prepared and incubated in media containing different concentrations of KLH or native HSA. These primed cells responded to some concentrations of KLH with the synthesis not only of homologous antibody but of heterologous IgG antibody to HSA. They also responded to some concentrations of HSA with the production of heterologous antibody to KLH as well as homologous antibody. In some experiments the addition of KLH induced the cells to synthesize as much antibody to HSA as did the addition of HSA itself. The nonspecific stimulation of the anamnestic antibody response to HSA required the cultures to contain KLH, HSA, KLH-reactive memory cells and, presumably memory cells reactive with HSA.The suspension of KLH-and HSA-primed cells responded to other concentrations of KLH or egg albumin (EA) with inhibition of the antibody response to HSA. This non-specific inhibition did not require lymph node cells which had been primed by the previous injection of KLH or EA.KLH and HSA did not cross-react with respect to immunogenicity in vitro or in vivo or reactivity with antibody in vitro.According to a model which was proposed, the KLH induced KLH-reactive T lymphocytes to produce soluble factor(s) which regulated the response of HSA-reactive B lymphocytes to HSA-specific determinants which persisted from the original injection." @default.
- W2198552972 created "2016-06-24" @default.
- W2198552972 creator A5012716370 @default.
- W2198552972 creator A5080972507 @default.
- W2198552972 date "1972-01-01" @default.
- W2198552972 modified "2023-09-23" @default.
- W2198552972 title "In Vitro Regulation of the Anamnestic Antibody Response Upon Addition of Heterologous Antigens to Primed Lymphoid Cells" @default.
- W2198552972 cites W1547751414 @default.
- W2198552972 cites W1982587463 @default.
- W2198552972 cites W2000310005 @default.
- W2198552972 cites W2006413595 @default.
- W2198552972 cites W2055226978 @default.
- W2198552972 cites W2056269741 @default.
- W2198552972 cites W2068973446 @default.
- W2198552972 cites W2077996503 @default.
- W2198552972 cites W2078794607 @default.
- W2198552972 cites W2109612147 @default.
- W2198552972 cites W2315807648 @default.
- W2198552972 doi "https://doi.org/10.3109/08820137209022959" @default.
- W2198552972 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/4680355" @default.
- W2198552972 hasPublicationYear "1972" @default.
- W2198552972 type Work @default.
- W2198552972 sameAs 2198552972 @default.
- W2198552972 citedByCount "7" @default.
- W2198552972 crossrefType "journal-article" @default.
- W2198552972 hasAuthorship W2198552972A5012716370 @default.
- W2198552972 hasAuthorship W2198552972A5080972507 @default.
- W2198552972 hasConcept C104317684 @default.
- W2198552972 hasConcept C147483822 @default.
- W2198552972 hasConcept C153911025 @default.
- W2198552972 hasConcept C159654299 @default.
- W2198552972 hasConcept C185592680 @default.
- W2198552972 hasConcept C202751555 @default.
- W2198552972 hasConcept C203014093 @default.
- W2198552972 hasConcept C2776727803 @default.
- W2198552972 hasConcept C2778597219 @default.
- W2198552972 hasConcept C2779915011 @default.
- W2198552972 hasConcept C2780115692 @default.
- W2198552972 hasConcept C2780868878 @default.
- W2198552972 hasConcept C55493867 @default.
- W2198552972 hasConcept C86803240 @default.
- W2198552972 hasConceptScore W2198552972C104317684 @default.
- W2198552972 hasConceptScore W2198552972C147483822 @default.
- W2198552972 hasConceptScore W2198552972C153911025 @default.
- W2198552972 hasConceptScore W2198552972C159654299 @default.
- W2198552972 hasConceptScore W2198552972C185592680 @default.
- W2198552972 hasConceptScore W2198552972C202751555 @default.
- W2198552972 hasConceptScore W2198552972C203014093 @default.
- W2198552972 hasConceptScore W2198552972C2776727803 @default.
- W2198552972 hasConceptScore W2198552972C2778597219 @default.
- W2198552972 hasConceptScore W2198552972C2779915011 @default.
- W2198552972 hasConceptScore W2198552972C2780115692 @default.
- W2198552972 hasConceptScore W2198552972C2780868878 @default.
- W2198552972 hasConceptScore W2198552972C55493867 @default.
- W2198552972 hasConceptScore W2198552972C86803240 @default.
- W2198552972 hasIssue "5" @default.
- W2198552972 hasLocation W21985529721 @default.
- W2198552972 hasLocation W21985529722 @default.
- W2198552972 hasOpenAccess W2198552972 @default.
- W2198552972 hasPrimaryLocation W21985529721 @default.
- W2198552972 hasRelatedWork W1131056809 @default.
- W2198552972 hasRelatedWork W1482659481 @default.
- W2198552972 hasRelatedWork W1508291394 @default.
- W2198552972 hasRelatedWork W1541476921 @default.
- W2198552972 hasRelatedWork W1549031222 @default.
- W2198552972 hasRelatedWork W1617229007 @default.
- W2198552972 hasRelatedWork W1978858659 @default.
- W2198552972 hasRelatedWork W2013671168 @default.
- W2198552972 hasRelatedWork W2065806719 @default.
- W2198552972 hasRelatedWork W2198552972 @default.
- W2198552972 hasVolume "1" @default.
- W2198552972 isParatext "false" @default.
- W2198552972 isRetracted "false" @default.
- W2198552972 magId "2198552972" @default.
- W2198552972 workType "article" @default.