FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2198635648> ?p ?o ?g. }

• W2198635648 abstract "There is increasing concern about the potential for nephrotoxicity in patients with chronic hepatitis B (CHB) treated long-term with nucleotide analogs.We examined renal dysfunction and its associated risk factors in patients with CHB treated with antiviral regimens containing either nucleosides or nucleotide analogs. We undertook a retrospective cohort study from 2006 to 2014 at the Hospital for Tropical Diseases, Bangkok, Thailand, and analyzed the data of 102 patients with a median follow-up time of 44.5 months (range 4-101 months).Seventy-three patients were treated with an antiviral regime containing a nucleoside analog, and 29 with a regime containing a nucleotide analog. Abnormally elevated serum creatinine concentration was observed in 12 patients (11.8 %) after 8 years of treatment. Thirty one percent of patients treated with nucleotide analogs had elevated serum creatinine levels and three of these patients (10.3 %) developed nephrotoxicity. In contrast, serum creatinine concentrations were elevated in three of the 73 patients treated with a nucleoside analog (4.1 %), and none developed nephrotoxicity. The incidence of renal dysfunction by the nucleotide analog regimen was cumulative, with 11.1, 21.0, 26.5 and 47.6 % of patients affected after 2, 4, 6 and 8 years, respectively. Univariate and multivariate analysis indicated that a nucleotide analog-based regimen significantly predicted renal dysfunction (odds ratio 10.5, 95 % confidence intervals 2.6-42.4, P <0.001).The long-term use of nucleotide analogs increased the risk of nephrotoxicity in patients with CHB. Thus, the regular assessment of renal function is recommended for all patients with CHB, particularly those treated with a nucleotide analog." @default.
• W2198635648 created "2016-06-24" @default.
• W2198635648 creator A5021610593 @default.
• W2198635648 creator A5027391063 @default.
• W2198635648 creator A5037479612 @default.
• W2198635648 creator A5052635259 @default.
• W2198635648 creator A5061745439 @default.
• W2198635648 creator A5069560390 @default.
• W2198635648 creator A5079209660 @default.
• W2198635648 creator A5083960272 @default.
• W2198635648 creator A5089194097 @default.
• W2198635648 date "2015-12-01" @default.
• W2198635648 modified "2023-10-09" @default.
• W2198635648 title "Nephrotoxicity caused by oral antiviral agents in patients with chronic hepatitis B treated in a hospital for tropical diseases in Thailand" @default.
• W2198635648 cites W1977793801 @default.
• W2198635648 cites W1985644058 @default.
• W2198635648 cites W1986864408 @default.
• W2198635648 cites W1987753756 @default.
• W2198635648 cites W1995744590 @default.
• W2198635648 cites W2001589305 @default.
• W2198635648 cites W2009509017 @default.
• W2198635648 cites W2013875474 @default.
• W2198635648 cites W2018706343 @default.
• W2198635648 cites W2020985855 @default.
• W2198635648 cites W2024324088 @default.
• W2198635648 cites W2027897535 @default.
• W2198635648 cites W2030888755 @default.
• W2198635648 cites W2031317669 @default.
• W2198635648 cites W2041179784 @default.
• W2198635648 cites W2044951291 @default.
• W2198635648 cites W2055339444 @default.
• W2198635648 cites W2063546567 @default.
• W2198635648 cites W2075135851 @default.
• W2198635648 cites W2076571011 @default.
• W2198635648 cites W2091989309 @default.
• W2198635648 cites W2145349124 @default.
• W2198635648 cites W2152331550 @default.
• W2198635648 cites W2168682946 @default.
• W2198635648 cites W2393327590 @default.
• W2198635648 cites W836635215 @default.
• W2198635648 doi "https://doi.org/10.1186/s40360-015-0037-6" @default.
• W2198635648 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4677430" @default.
• W2198635648 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26651337" @default.
• W2198635648 hasPublicationYear "2015" @default.
• W2198635648 type Work @default.
• W2198635648 sameAs 2198635648 @default.
• W2198635648 citedByCount "5" @default.
• W2198635648 countsByYear W21986356482016 @default.
• W2198635648 countsByYear W21986356482017 @default.
• W2198635648 countsByYear W21986356482018 @default.
• W2198635648 countsByYear W21986356482019 @default.
• W2198635648 crossrefType "journal-article" @default.
• W2198635648 hasAuthorship W2198635648A5021610593 @default.
• W2198635648 hasAuthorship W2198635648A5027391063 @default.
• W2198635648 hasAuthorship W2198635648A5037479612 @default.
• W2198635648 hasAuthorship W2198635648A5052635259 @default.
• W2198635648 hasAuthorship W2198635648A5061745439 @default.
• W2198635648 hasAuthorship W2198635648A5069560390 @default.
• W2198635648 hasAuthorship W2198635648A5079209660 @default.
• W2198635648 hasAuthorship W2198635648A5083960272 @default.
• W2198635648 hasAuthorship W2198635648A5089194097 @default.
• W2198635648 hasBestOaLocation W21986356481 @default.
• W2198635648 hasConcept C126189478 @default.
• W2198635648 hasConcept C126322002 @default.
• W2198635648 hasConcept C144301174 @default.
• W2198635648 hasConcept C156957248 @default.
• W2198635648 hasConcept C159641895 @default.
• W2198635648 hasConcept C2777382497 @default.
• W2198635648 hasConcept C2778653478 @default.
• W2198635648 hasConcept C2780091579 @default.
• W2198635648 hasConcept C2780306776 @default.
• W2198635648 hasConcept C2781413609 @default.
• W2198635648 hasConcept C38180746 @default.
• W2198635648 hasConcept C71924100 @default.
• W2198635648 hasConcept C90924648 @default.
• W2198635648 hasConceptScore W2198635648C126189478 @default.
• W2198635648 hasConceptScore W2198635648C126322002 @default.
• W2198635648 hasConceptScore W2198635648C144301174 @default.
• W2198635648 hasConceptScore W2198635648C156957248 @default.
• W2198635648 hasConceptScore W2198635648C159641895 @default.
• W2198635648 hasConceptScore W2198635648C2777382497 @default.
• W2198635648 hasConceptScore W2198635648C2778653478 @default.
• W2198635648 hasConceptScore W2198635648C2780091579 @default.
• W2198635648 hasConceptScore W2198635648C2780306776 @default.
• W2198635648 hasConceptScore W2198635648C2781413609 @default.
• W2198635648 hasConceptScore W2198635648C38180746 @default.
• W2198635648 hasConceptScore W2198635648C71924100 @default.
• W2198635648 hasConceptScore W2198635648C90924648 @default.
• W2198635648 hasFunder F4320335147 @default.
• W2198635648 hasIssue "1" @default.
• W2198635648 hasLocation W21986356481 @default.
• W2198635648 hasLocation W21986356482 @default.
• W2198635648 hasLocation W21986356483 @default.
• W2198635648 hasLocation W21986356484 @default.
• W2198635648 hasOpenAccess W2198635648 @default.
• W2198635648 hasPrimaryLocation W21986356481 @default.
• W2198635648 hasRelatedWork W1030837842 @default.
• W2198635648 hasRelatedWork W2042710484 @default.
• W2198635648 hasRelatedWork W2058466993 @default.
• W2198635648 hasRelatedWork W2084889883 @default.

• next