Matches in SemOpenAlex for { <https://semopenalex.org/work/W2198959093> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2198959093 abstract "s / Pancreatology 15 (2015) S1eS141 S33 Materials & methods: In vitro, pancreatic cancer cell survival, migration, invasion, and epithelial-to-mesenchymal transition (EMT) were assessed upon exposure with conditioned media obtained from CAF primary cultures isolated from human PDA resections. In vivo, pancreatic tumor growth and metastases were explored in athymic mice orthotopically co-xenografted with CAFs and pancreatic cancer cells. Results: We demonstrated that the dramatic increase in pancreatic cancer cell survival, migration, invasion and EMT, induced by CAF's conditioned media is abolished when CAFs are previously treated with the multi-receptor somatostatin analog SOM230 (pasireotide). Mechanistically, SOM230 acts through the somatostatin receptor sub-type sst1 exclusively expressed in CAFs, to inhibit mTORC1-4E-BP1-protein synthesis pathway. Functional analyses of CAF secreted mediators demonstrated that IL-6 is critically involved in their pro-tumoral features in a phosphoinositide 3-kinase-dependent manner. In vivo, SOM230 treatment of xenografted mice demonstrated a potent anti-metastatic potential. Conclusion: Our results highlight a novel promising antimetastatic activity for SOM230 indirectly targeting pancreatic cancer cells through pharmacological inhibition of stromal CAFs." @default.
- W2198959093 created "2016-06-24" @default.
- W2198959093 creator A5001164379 @default.
- W2198959093 creator A5015386151 @default.
- W2198959093 creator A5017183454 @default.
- W2198959093 creator A5026049234 @default.
- W2198959093 creator A5031667128 @default.
- W2198959093 creator A5067780549 @default.
- W2198959093 creator A5076979609 @default.
- W2198959093 creator A5082485345 @default.
- W2198959093 creator A5089418989 @default.
- W2198959093 creator A5089550509 @default.
- W2198959093 date "2015-06-01" @default.
- W2198959093 modified "2023-10-03" @default.
- W2198959093 title "Periostin promotes pancreatic carcinogenesis and metastatic spread" @default.
- W2198959093 doi "https://doi.org/10.1016/j.pan.2015.05.145" @default.
- W2198959093 hasPublicationYear "2015" @default.
- W2198959093 type Work @default.
- W2198959093 sameAs 2198959093 @default.
- W2198959093 citedByCount "0" @default.
- W2198959093 crossrefType "journal-article" @default.
- W2198959093 hasAuthorship W2198959093A5001164379 @default.
- W2198959093 hasAuthorship W2198959093A5015386151 @default.
- W2198959093 hasAuthorship W2198959093A5017183454 @default.
- W2198959093 hasAuthorship W2198959093A5026049234 @default.
- W2198959093 hasAuthorship W2198959093A5031667128 @default.
- W2198959093 hasAuthorship W2198959093A5067780549 @default.
- W2198959093 hasAuthorship W2198959093A5076979609 @default.
- W2198959093 hasAuthorship W2198959093A5082485345 @default.
- W2198959093 hasAuthorship W2198959093A5089418989 @default.
- W2198959093 hasAuthorship W2198959093A5089550509 @default.
- W2198959093 hasConcept C121608353 @default.
- W2198959093 hasConcept C126322002 @default.
- W2198959093 hasConcept C142724271 @default.
- W2198959093 hasConcept C150903083 @default.
- W2198959093 hasConcept C16930146 @default.
- W2198959093 hasConcept C189165786 @default.
- W2198959093 hasConcept C198826908 @default.
- W2198959093 hasConcept C207001950 @default.
- W2198959093 hasConcept C2776297358 @default.
- W2198959093 hasConcept C2777699602 @default.
- W2198959093 hasConcept C2780210213 @default.
- W2198959093 hasConcept C502942594 @default.
- W2198959093 hasConcept C71924100 @default.
- W2198959093 hasConcept C80115893 @default.
- W2198959093 hasConcept C86803240 @default.
- W2198959093 hasConcept C95444343 @default.
- W2198959093 hasConceptScore W2198959093C121608353 @default.
- W2198959093 hasConceptScore W2198959093C126322002 @default.
- W2198959093 hasConceptScore W2198959093C142724271 @default.
- W2198959093 hasConceptScore W2198959093C150903083 @default.
- W2198959093 hasConceptScore W2198959093C16930146 @default.
- W2198959093 hasConceptScore W2198959093C189165786 @default.
- W2198959093 hasConceptScore W2198959093C198826908 @default.
- W2198959093 hasConceptScore W2198959093C207001950 @default.
- W2198959093 hasConceptScore W2198959093C2776297358 @default.
- W2198959093 hasConceptScore W2198959093C2777699602 @default.
- W2198959093 hasConceptScore W2198959093C2780210213 @default.
- W2198959093 hasConceptScore W2198959093C502942594 @default.
- W2198959093 hasConceptScore W2198959093C71924100 @default.
- W2198959093 hasConceptScore W2198959093C80115893 @default.
- W2198959093 hasConceptScore W2198959093C86803240 @default.
- W2198959093 hasConceptScore W2198959093C95444343 @default.
- W2198959093 hasLocation W21989590931 @default.
- W2198959093 hasOpenAccess W2198959093 @default.
- W2198959093 hasPrimaryLocation W21989590931 @default.
- W2198959093 hasRelatedWork W1481294161 @default.
- W2198959093 hasRelatedWork W1585127947 @default.
- W2198959093 hasRelatedWork W1985649037 @default.
- W2198959093 hasRelatedWork W2116746706 @default.
- W2198959093 hasRelatedWork W2133506852 @default.
- W2198959093 hasRelatedWork W2153450196 @default.
- W2198959093 hasRelatedWork W2325272952 @default.
- W2198959093 hasRelatedWork W2593800477 @default.
- W2198959093 hasRelatedWork W2745178996 @default.
- W2198959093 hasRelatedWork W2769277514 @default.
- W2198959093 hasRelatedWork W2804047512 @default.
- W2198959093 hasRelatedWork W2810023065 @default.
- W2198959093 hasRelatedWork W2921558231 @default.
- W2198959093 hasRelatedWork W2944887118 @default.
- W2198959093 hasRelatedWork W2969520818 @default.
- W2198959093 hasRelatedWork W3006360681 @default.
- W2198959093 hasRelatedWork W3126758049 @default.
- W2198959093 hasRelatedWork W3158934247 @default.
- W2198959093 hasRelatedWork W3174408211 @default.
- W2198959093 hasRelatedWork W2398317880 @default.
- W2198959093 isParatext "false" @default.
- W2198959093 isRetracted "false" @default.
- W2198959093 magId "2198959093" @default.
- W2198959093 workType "article" @default.