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• W2199016288 abstract "It has been reported that T cell numbers are maintained in adults predominantly through the expansion of post-thymic, memory T cells, whereas in infants, T cells are predominantly maintained through the production of new naïve T cells by the thymus t. However, we and others have recently demonstrated that the adult thymus is still capable of thymopoiesis and can contribute to T cell reconstitution in adults 2, 3. Several methods have been used to measure thymopoietic capacity. Thymic size as measured by radiographic imaging t or volumetric computerized tomograph measurements 4’ 5 has been correlated with numbers of CD4+CD45RA+ naïve T cells and the number of phenotypically naïve T cells after transplantation has been shown to correlate with antigen-specific function 6. However, there are concerns about limitations of estimating thymic function based on naïve T cell phenotype alone. T cells expressing a naïve phenotype are not necessarily accurate surrogate markers of thymic function. Following thymic emigration, CD45RA+ naïve T cells can have a long quiescent lifespan 7, may proliferate in an antigen-independent manner 8, or may rapidly convert to CD45RO+ memory/effector phenotype T cells 9. Furthermore, naïve T cell markers may be acquired by memory T cells (especially CDS+ T cells) 9, further compounding the difficulty in accurate enumeration of naïve T cells 10,1 t" @default.
• W2199016288 created "2016-06-24" @default.
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• W2199016288 date "2002-01-01" @default.
• W2199016288 modified "2023-10-12" @default.
• W2199016288 title "IL-7, The thymus, and Naïve T Cells" @default.
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• W2199016288 doi "https://doi.org/10.1007/978-1-4615-0757-4_11" @default.
• W2199016288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12405190" @default.
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