Matches in SemOpenAlex for { <https://semopenalex.org/work/W21990241> ?p ?o ?g. }
- W21990241 endingPage "331" @default.
- W21990241 startingPage "321" @default.
- W21990241 abstract "Inflammatory reaction surrounding the ablated area is a major confounding factor in the early detection of viable tumor after radiofrequency (RF) ablation. A difference in the responsiveness of normal and tumor blood vessels to vasoactive agents may be used to distinguish these regions in post-ablation follow-up. The goal of this study was to examine longitudinal perfusion changes in untreated viable tumor and the peripheral hyperemic rim of RF-ablated tumor in response to a vasoconstrictor (phenylephrine) or vasodilator (hydralazine) in a subcutaneous rat tumor model.Bilateral subcutaneous shoulder tumors were inoculated in 24 BDIX rats and evenly divided into two groups (phenylephrine and hydralazine groups). One tumor in each animal was completely treated with RF ablation (at 90 +/- 2 degrees C for 3 minutes), and the other remained untreated. Computed tomographic perfusion scans before and after phenylephrine (10 microg/kg) or hydralazine (5 mg/kg) administration were performed 2, 7, and 14 days after ablation. Four rats per group were euthanized on each scan day, and pathologic evaluation was performed. The changes of blood flow in the peripheral rim of ablated tumor and untreated viable tumor in response to phenylephrine or hydralazine at each time point were compared. The diagnostic accuracy of viable tumor using the percentage change of blood flow in response to phenylephrine and hydralazine was compared using receiver-operating characteristic analysis.The peripheral rim of ablated tumor presented with a hyperemic reaction with dilated vessels and congestion on day 2 after ablation, numerous inflammatory vessels on day 7, and granulation tissue formation on day 14. Phenylephrine significantly decreased the blood flow in the peripheral hyperemic rim of ablated tumor on days 2, 7, and 14 by 16.3 +/- 9.7% (P = .001), 24.0 +/- 22.6% (P = .007), and 31.1 +/- 25.4% (P = .045), respectively. In untreated viable tumor, the change in blood flow after phenylephrine was irregular and insignificant. Hydralazine decreased the blood flow in the peripheral rim of both ablated tumor and untreated viable tumor. Receiver-operating characteristic analysis showed that reliable tumor diagnosis using the percentage change of blood flow in response to phenylephrine was noted on days 2 and 7, for which the areas under the curve were 0.82 (95% confidence interval, 0.64-1.00) and 0.81 (95% confidence interval, 0.56-1.00), respectively. However, tumor diagnosis using the blood flow change in response to hydralazine was unreliable.Phenylephrine markedly decreased blood flow in the peripheral hyperemic rim of ablated tumor but had little effect on the untreated viable tumor. Computed tomographic perfusion with phenylephrine may be useful in the long-term treatment assessment of RF ablation." @default.
- W21990241 created "2016-06-24" @default.
- W21990241 creator A5026282888 @default.
- W21990241 creator A5038760567 @default.
- W21990241 creator A5045127913 @default.
- W21990241 creator A5066766358 @default.
- W21990241 creator A5075423015 @default.
- W21990241 creator A5076771130 @default.
- W21990241 date "2009-03-01" @default.
- W21990241 modified "2023-09-23" @default.
- W21990241 title "Radiofrequency Ablation" @default.
- W21990241 cites W122478359 @default.
- W21990241 cites W1519745137 @default.
- W21990241 cites W1972579825 @default.
- W21990241 cites W1980236184 @default.
- W21990241 cites W1985172851 @default.
- W21990241 cites W1993866602 @default.
- W21990241 cites W1998000914 @default.
- W21990241 cites W2000537464 @default.
- W21990241 cites W2018269740 @default.
- W21990241 cites W2023298136 @default.
- W21990241 cites W2035871872 @default.
- W21990241 cites W2035984559 @default.
- W21990241 cites W2067865889 @default.
- W21990241 cites W2072740741 @default.
- W21990241 cites W2083246937 @default.
- W21990241 cites W2084713314 @default.
- W21990241 cites W2087656963 @default.
- W21990241 cites W2125132262 @default.
- W21990241 cites W2136596547 @default.
- W21990241 cites W2151418705 @default.
- W21990241 cites W2157668569 @default.
- W21990241 cites W2163957808 @default.
- W21990241 cites W2171416930 @default.
- W21990241 cites W2171953456 @default.
- W21990241 cites W2289249866 @default.
- W21990241 cites W4293029089 @default.
- W21990241 doi "https://doi.org/10.1016/j.acra.2008.09.008" @default.
- W21990241 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3309415" @default.
- W21990241 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19201361" @default.
- W21990241 hasPublicationYear "2009" @default.
- W21990241 type Work @default.
- W21990241 sameAs 21990241 @default.
- W21990241 citedByCount "11" @default.
- W21990241 countsByYear W219902412012 @default.
- W21990241 countsByYear W219902412013 @default.
- W21990241 countsByYear W219902412014 @default.
- W21990241 countsByYear W219902412015 @default.
- W21990241 countsByYear W219902412016 @default.
- W21990241 countsByYear W219902412020 @default.
- W21990241 countsByYear W219902412021 @default.
- W21990241 countsByYear W219902412022 @default.
- W21990241 crossrefType "journal-article" @default.
- W21990241 hasAuthorship W21990241A5026282888 @default.
- W21990241 hasAuthorship W21990241A5038760567 @default.
- W21990241 hasAuthorship W21990241A5045127913 @default.
- W21990241 hasAuthorship W21990241A5066766358 @default.
- W21990241 hasAuthorship W21990241A5075423015 @default.
- W21990241 hasAuthorship W21990241A5076771130 @default.
- W21990241 hasBestOaLocation W219902412 @default.
- W21990241 hasConcept C126322002 @default.
- W21990241 hasConcept C126894567 @default.
- W21990241 hasConcept C146957229 @default.
- W21990241 hasConcept C158846371 @default.
- W21990241 hasConcept C2777377203 @default.
- W21990241 hasConcept C2777952589 @default.
- W21990241 hasConcept C2778902805 @default.
- W21990241 hasConcept C2780521442 @default.
- W21990241 hasConcept C2989005 @default.
- W21990241 hasConcept C46762472 @default.
- W21990241 hasConcept C71924100 @default.
- W21990241 hasConcept C84393581 @default.
- W21990241 hasConceptScore W21990241C126322002 @default.
- W21990241 hasConceptScore W21990241C126894567 @default.
- W21990241 hasConceptScore W21990241C146957229 @default.
- W21990241 hasConceptScore W21990241C158846371 @default.
- W21990241 hasConceptScore W21990241C2777377203 @default.
- W21990241 hasConceptScore W21990241C2777952589 @default.
- W21990241 hasConceptScore W21990241C2778902805 @default.
- W21990241 hasConceptScore W21990241C2780521442 @default.
- W21990241 hasConceptScore W21990241C2989005 @default.
- W21990241 hasConceptScore W21990241C46762472 @default.
- W21990241 hasConceptScore W21990241C71924100 @default.
- W21990241 hasConceptScore W21990241C84393581 @default.
- W21990241 hasIssue "3" @default.
- W21990241 hasLocation W219902411 @default.
- W21990241 hasLocation W219902412 @default.
- W21990241 hasLocation W219902413 @default.
- W21990241 hasLocation W219902414 @default.
- W21990241 hasOpenAccess W21990241 @default.
- W21990241 hasPrimaryLocation W219902411 @default.
- W21990241 hasRelatedWork W1970195707 @default.
- W21990241 hasRelatedWork W2058269092 @default.
- W21990241 hasRelatedWork W2084835819 @default.
- W21990241 hasRelatedWork W2102240528 @default.
- W21990241 hasRelatedWork W2117625558 @default.
- W21990241 hasRelatedWork W2132430687 @default.
- W21990241 hasRelatedWork W2154641732 @default.