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• W2199037100 abstract "The ability of an organism to adapt to aversive stressfulsituations or life challenging circumstances is very crucial to its state of healthand survival. However, breakdown in adaptation due to persistent uncontrollablestress, leads to impairment of bodily functions and onset of a variety of pathologicaldisorders especially memory decline. This study was designed to evaluate the effectof Jobelyn® (JB), a potent antioxidant sorghum-based food supplementon unpredictable chronic mild stress (UCMS)-induced memory impairment in mice. MaleSwiss mice were given JB (5 - 50mg/kg, p.o) 30 min prior to exposure to UCMS for 14 consecutive days beforetesting for memory. Thereafter, the serum corticosterone level was estimatedby using ELISA kits. The levels of malondialdehyde (MDA) and glutathione (GSH) as well as acetylcholinesterase activitywere estimated in the brain homogenate using spectrophotometer. Histology of thebrain tissues and estimation of the populations of viable neurons in the hippocampalregion were done after staining with hematoxyline and eosin. Our results showed that JB reversed memoryimpairment and suppressed corticosterone concentrations induced by UCMS. Moreover,JB reduced oxidative stress in the brain of UCMS-mice as shown by decreased MDA levels and elevated GSH concentrations. It also decreasedbrain acetylcholinesterase activity when compared with chronic stress group (p <0.05). Furthermore, JB (5 - 10 mg/kg, p.o) offered significant protection againstUCMS-induced degeneration and death of neuronal cells of the cornu ammonis 3 (CA3)of the hippocampal region of the brain indicating neuroprotection. Taken together,these findings suggest that JB attenuates memory deficits induced by UCMS in miceand may be useful therapeutically for stress-related cognitive dysfunctions. Thereduction in the levels of serum corticosterone, antioxidation, neuroprotectionand inhibition of cholinesterase enzyme might be contributing significantly to thepositive effect of JB on memory in mice exposed to unpredictable chronic mild stress." @default.
• W2199037100 created "2016-06-24" @default.
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• W2199037100 date "2015-01-01" @default.
• W2199037100 modified "2023-09-26" @default.
• W2199037100 title "Jobelyn^&reg;, a Sorghum-Based Nutritional Supplement Attenuates Unpredictable Chronic Mild Stress-Induced Memory Deficits in Mice" @default.
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• W2199037100 doi "https://doi.org/10.4236/jbbs.2015.513056" @default.
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