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- W2199117770 abstract "This poster will describe research conducted at the MIND Research Network,UNM HSC Psychiatry Department, and UNM Center on Alcoholism, Substance Abuse, and Addictions, as well as further directions to be be taken with the study. We used magnetoencephalography (MEG) to investigate the auditory ‘augmenting/reducing’ paradigm in patients with post-traumatic stress disorder (PTSD). In classic augmenting/reducing experiments, auditory tones of variable loudness are played to subjects while their neural activity is monitored with electroencephalography (EEG). The EEG response amplitude near 200ms post-stimulus in control subjects generally exhibits a linear relationship to loudness: louder tones elicit greater response, an ‘augmenting’ relationship. The response in many subjects with PTSD to louder sounds, however, stops increasing or decreases in response to louder sounds upon reaching a threshold loudness (approximately 85 dB), showing a ‘reducing’ relationship. Previous experiments measured augmenting and reducing using only EEG, which measures the response amplitude without localizing the signal source. We replicated the augmenting/reducing experiment using simultaneous EEG and MEG to localize the source of response activity. Prior analysis in our lab has shown that auditory cortex activation, an area generally involved in response to auditory stimuli, does not completely account for the EEG response. We will perform regression analysis of activation area against loudness in order to find possible regions responsible for inhibiting the response in subjects with PTSD. This analysis may provide insight into neural and psychological causes of the reduced EEG response. We will also examine the relationship between ‘reducing’ and PTSD symptom severity, as measured by the CAPS scale and other tests, to test how closely ‘reducing’ correlates with behavioral aspects of PTSD. The poster will describe and visualize results of source localization and correlations between neuropsychological variables and EEG/MEG response. Implications and future research directions will also be discussed." @default.
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- W2199117770 date "2013-01-01" @default.
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- W2199117770 title "Localization of Inhibited Neural Response in Subjects with Post-Traumatic Stress Disorder" @default.
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