Matches in SemOpenAlex for { <https://semopenalex.org/work/W2199151507> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2199151507 endingPage "752.e3" @default.
- W2199151507 startingPage "746" @default.
- W2199151507 abstract "Transient acute reversible lymphopenia occurring within hours after glucocorticoid administration is a well-known phenomenon. The objective of this study was to establish the impact of chronic methylprednisolone (mPDN) administration on lymphocyte counts in patients with immune-mediated inflammatory disorders.The charts of 44 women and 17 men (median age, 59 years) with several immune-mediated inflammatory disorders receiving oral mPDN for at least 4 months were reviewed. Morning lymphocyte counts measured during treatment (LP) were compared with pretreatment values (LA). In addition, the acute effect of mPDN on lymphocyte counts was evaluated in 43 of these patients by quantifying lymphocyte subpopulations before and 8 hours after mPDN administration. Values are expressed as median with 25%-75% interquartile range.The initial daily oral mPDN dose was 28 mg (12-32 mg). An increase in morning lymphocyte counts was detected 13 days (8.5-16 days) after initiation of mPDN treatment (LP: 2130/μL vs LA: 1650/μL; P = .0121) and persisted over time. Morning lymphocytosis (LP ≥4000/μL) was observed in 15 patients, including 7 with hyperlymphocytosis (LP ≥5000/μL). The increase in morning lymphocyte counts during treatment was most marked for CD4 T cells. In the subset of patients who agreed to a second blood test after mPDN absorption, a 49% decrease in the lymphocyte count (P <.0001) was transiently observed at the 8-hour time point.A significant increase of the morning lymphocyte count is frequently observed in patients with immune-mediated inflammatory disorders chronically treated with oral mPDN. Heightened awareness that the timing of blood sampling in corticosteroid-treated patients affects lymphocyte counts, with possible hyperlymphocytosis before absorption, should help avoid unnecessary investigations and worry." @default.
- W2199151507 created "2016-06-24" @default.
- W2199151507 creator A5024851869 @default.
- W2199151507 creator A5048483620 @default.
- W2199151507 creator A5065181686 @default.
- W2199151507 creator A5065756605 @default.
- W2199151507 creator A5068735109 @default.
- W2199151507 creator A5072613674 @default.
- W2199151507 creator A5080850235 @default.
- W2199151507 date "2016-07-01" @default.
- W2199151507 modified "2023-09-27" @default.
- W2199151507 title "Methylprednisolone-Induced Lymphocytosis in Patients with Immune-Mediated Inflammatory Disorders" @default.
- W2199151507 cites W1964681740 @default.
- W2199151507 cites W1977047809 @default.
- W2199151507 cites W2016074676 @default.
- W2199151507 cites W2024977437 @default.
- W2199151507 cites W2026146807 @default.
- W2199151507 cites W2031922967 @default.
- W2199151507 cites W2032949137 @default.
- W2199151507 cites W2040982724 @default.
- W2199151507 cites W2047111125 @default.
- W2199151507 cites W2054152453 @default.
- W2199151507 cites W2056528694 @default.
- W2199151507 cites W2076863034 @default.
- W2199151507 cites W2082905866 @default.
- W2199151507 cites W2084995200 @default.
- W2199151507 cites W2097974226 @default.
- W2199151507 cites W2099829129 @default.
- W2199151507 cites W2145972397 @default.
- W2199151507 cites W2150691073 @default.
- W2199151507 cites W4213039537 @default.
- W2199151507 doi "https://doi.org/10.1016/j.amjmed.2016.02.013" @default.
- W2199151507 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26968468" @default.
- W2199151507 hasPublicationYear "2016" @default.
- W2199151507 type Work @default.
- W2199151507 sameAs 2199151507 @default.
- W2199151507 citedByCount "8" @default.
- W2199151507 countsByYear W21991515072017 @default.
- W2199151507 countsByYear W21991515072019 @default.
- W2199151507 countsByYear W21991515072020 @default.
- W2199151507 countsByYear W21991515072021 @default.
- W2199151507 countsByYear W21991515072022 @default.
- W2199151507 countsByYear W21991515072023 @default.
- W2199151507 crossrefType "journal-article" @default.
- W2199151507 hasAuthorship W2199151507A5024851869 @default.
- W2199151507 hasAuthorship W2199151507A5048483620 @default.
- W2199151507 hasAuthorship W2199151507A5065181686 @default.
- W2199151507 hasAuthorship W2199151507A5065756605 @default.
- W2199151507 hasAuthorship W2199151507A5068735109 @default.
- W2199151507 hasAuthorship W2199151507A5072613674 @default.
- W2199151507 hasAuthorship W2199151507A5080850235 @default.
- W2199151507 hasConcept C119060515 @default.
- W2199151507 hasConcept C126322002 @default.
- W2199151507 hasConcept C19720800 @default.
- W2199151507 hasConcept C203014093 @default.
- W2199151507 hasConcept C2777761686 @default.
- W2199151507 hasConcept C2777802486 @default.
- W2199151507 hasConcept C2780126324 @default.
- W2199151507 hasConcept C2780372218 @default.
- W2199151507 hasConcept C2780841215 @default.
- W2199151507 hasConcept C71924100 @default.
- W2199151507 hasConcept C8891405 @default.
- W2199151507 hasConcept C90924648 @default.
- W2199151507 hasConceptScore W2199151507C119060515 @default.
- W2199151507 hasConceptScore W2199151507C126322002 @default.
- W2199151507 hasConceptScore W2199151507C19720800 @default.
- W2199151507 hasConceptScore W2199151507C203014093 @default.
- W2199151507 hasConceptScore W2199151507C2777761686 @default.
- W2199151507 hasConceptScore W2199151507C2777802486 @default.
- W2199151507 hasConceptScore W2199151507C2780126324 @default.
- W2199151507 hasConceptScore W2199151507C2780372218 @default.
- W2199151507 hasConceptScore W2199151507C2780841215 @default.
- W2199151507 hasConceptScore W2199151507C71924100 @default.
- W2199151507 hasConceptScore W2199151507C8891405 @default.
- W2199151507 hasConceptScore W2199151507C90924648 @default.
- W2199151507 hasIssue "7" @default.
- W2199151507 hasLocation W21991515071 @default.
- W2199151507 hasLocation W21991515072 @default.
- W2199151507 hasOpenAccess W2199151507 @default.
- W2199151507 hasPrimaryLocation W21991515071 @default.
- W2199151507 hasRelatedWork W1506984959 @default.
- W2199151507 hasRelatedWork W1970769266 @default.
- W2199151507 hasRelatedWork W2026431573 @default.
- W2199151507 hasRelatedWork W2056385328 @default.
- W2199151507 hasRelatedWork W2142814959 @default.
- W2199151507 hasRelatedWork W2149871822 @default.
- W2199151507 hasRelatedWork W2199151507 @default.
- W2199151507 hasRelatedWork W2422805264 @default.
- W2199151507 hasRelatedWork W2575644119 @default.
- W2199151507 hasRelatedWork W4294307798 @default.
- W2199151507 hasVolume "129" @default.
- W2199151507 isParatext "false" @default.
- W2199151507 isRetracted "false" @default.
- W2199151507 magId "2199151507" @default.
- W2199151507 workType "article" @default.