FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2199156677> ?p ?o ?g. }

• W2199156677 endingPage "872" @default.
• W2199156677 startingPage "863" @default.
• W2199156677 abstract "The extensive heterogeneity of breast cancer complicates the precise assessment of tumour aggressiveness, making therapeutic decisions difficult and treatments inappropriate in some cases. Consequently, the long-term metastasis-free survival rate of patients receiving adjuvant chemotherapy is only 60%. There is a genuine need to identify parameters that might accurately predict the effectiveness of this treatment for each patient. Using cDNA arrays, we profiled tumour samples from 55 women with poor-prognosis breast cancer treated with adjuvant anthracycline-based chemotherapy. Gene expression monitoring was applied to a set of about 1000 candidate cancer genes. Differences in expression profiles provided molecular evidence of the clinical heterogeneity of disease. First, we confirmed the capacity of a 23-gene predictor set, identified in a previous study, to distinguish between tumours associated with different survival. Second, using a refined gene set derived from the previous one, we distinguished, among the 55 clinically homogeneous tumours, three classes with significantly different clinical outcome: 5-year overall survival and metastasis-free survival rates were respectively 100% and 75% in the first class, 65% and 56% in the second and 40% and 20% in the third. This discrimination resulted from the differential expression of two clusters of genes encoding proteins with diverse functions, including the estrogen receptor (ER). Another finding was the identification of two ER-positive tumour subgroups with different survival. These results indicate that gene expression profiling can predict clinical outcome and lead to a more precise classification of breast tumours. Furthermore, the characterization of discriminator genes might accelerate the development of new specific and alternative therapies, allowing more rationally tailored treatments that are potentially more efficient and less toxic." @default.
• W2199156677 created "2016-06-24" @default.
• W2199156677 creator A5091721810 @default.
• W2199156677 date "2002-04-15" @default.
• W2199156677 modified "2023-10-12" @default.
• W2199156677 title "Gene expression profiles of poor-prognosis primary breast cancer correlate with survival" @default.
• W2199156677 cites W1262485082 @default.
• W2199156677 cites W1495406308 @default.
• W2199156677 cites W1501495997 @default.
• W2199156677 cites W1562190372 @default.
• W2199156677 cites W1651215666 @default.
• W2199156677 cites W1727290854 @default.
• W2199156677 cites W178915733 @default.
• W2199156677 cites W1932878073 @default.
• W2199156677 cites W1949238489 @default.
• W2199156677 cites W1969443066 @default.
• W2199156677 cites W1970517858 @default.
• W2199156677 cites W1979300931 @default.
• W2199156677 cites W1983546164 @default.
• W2199156677 cites W1987572677 @default.
• W2199156677 cites W1988078905 @default.
• W2199156677 cites W2008233728 @default.
• W2199156677 cites W2009439483 @default.
• W2199156677 cites W2014428384 @default.
• W2199156677 cites W2018843280 @default.
• W2199156677 cites W2025769699 @default.
• W2199156677 cites W2044551606 @default.
• W2199156677 cites W2049569603 @default.
• W2199156677 cites W2062233672 @default.
• W2199156677 cites W2072787342 @default.
• W2199156677 cites W2089279843 @default.
• W2199156677 cites W2097232179 @default.
• W2199156677 cites W2097255042 @default.
• W2199156677 cites W2097413644 @default.
• W2199156677 cites W2107267953 @default.
• W2199156677 cites W2107428528 @default.
• W2199156677 cites W2109363337 @default.
• W2199156677 cites W2121092400 @default.
• W2199156677 cites W2122128696 @default.
• W2199156677 cites W2131994307 @default.
• W2199156677 cites W2133408654 @default.
• W2199156677 cites W2141127028 @default.
• W2199156677 cites W2143024670 @default.
• W2199156677 cites W2143997044 @default.
• W2199156677 cites W2147246240 @default.
• W2199156677 cites W2150926065 @default.
• W2199156677 cites W2259897691 @default.
• W2199156677 cites W2287180088 @default.
• W2199156677 cites W2401428488 @default.
• W2199156677 cites W2407894080 @default.
• W2199156677 cites W2597616474 @default.
• W2199156677 cites W2098872446 @default.
• W2199156677 doi "https://doi.org/10.1093/hmg/11.8.863" @default.
• W2199156677 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11971868" @default.
• W2199156677 hasPublicationYear "2002" @default.
• W2199156677 type Work @default.
• W2199156677 sameAs 2199156677 @default.
• W2199156677 citedByCount "123" @default.
• W2199156677 countsByYear W21991566772012 @default.
• W2199156677 countsByYear W21991566772013 @default.
• W2199156677 countsByYear W21991566772014 @default.
• W2199156677 countsByYear W21991566772015 @default.
• W2199156677 countsByYear W21991566772016 @default.
• W2199156677 countsByYear W21991566772017 @default.
• W2199156677 countsByYear W21991566772019 @default.
• W2199156677 countsByYear W21991566772021 @default.
• W2199156677 countsByYear W21991566772023 @default.
• W2199156677 crossrefType "journal-article" @default.
• W2199156677 hasAuthorship W2199156677A5091721810 @default.
• W2199156677 hasBestOaLocation W21991566771 @default.
• W2199156677 hasConcept C104317684 @default.
• W2199156677 hasConcept C10515644 @default.
• W2199156677 hasConcept C121608353 @default.
• W2199156677 hasConcept C126322002 @default.
• W2199156677 hasConcept C143998085 @default.
• W2199156677 hasConcept C150194340 @default.
• W2199156677 hasConcept C18431079 @default.
• W2199156677 hasConcept C2776283816 @default.
• W2199156677 hasConcept C2776802502 @default.
• W2199156677 hasConcept C2779013556 @default.
• W2199156677 hasConcept C2779733811 @default.
• W2199156677 hasConcept C2779740036 @default.
• W2199156677 hasConcept C530470458 @default.
• W2199156677 hasConcept C54355233 @default.
• W2199156677 hasConcept C71924100 @default.
• W2199156677 hasConcept C84606932 @default.
• W2199156677 hasConcept C86803240 @default.
• W2199156677 hasConceptScore W2199156677C104317684 @default.
• W2199156677 hasConceptScore W2199156677C10515644 @default.
• W2199156677 hasConceptScore W2199156677C121608353 @default.
• W2199156677 hasConceptScore W2199156677C126322002 @default.
• W2199156677 hasConceptScore W2199156677C143998085 @default.
• W2199156677 hasConceptScore W2199156677C150194340 @default.
• W2199156677 hasConceptScore W2199156677C18431079 @default.
• W2199156677 hasConceptScore W2199156677C2776283816 @default.
• W2199156677 hasConceptScore W2199156677C2776802502 @default.
• W2199156677 hasConceptScore W2199156677C2779013556 @default.
• W2199156677 hasConceptScore W2199156677C2779733811 @default.

• next