FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2199173863> ?p ?o ?g. }

• W2199173863 endingPage "379" @default.
• W2199173863 startingPage "370" @default.
• W2199173863 abstract "Objective— Palmitoylation, the reversible addition of the lipid palmitate to a cysteine, can alter protein localization, stability, and function. The ZDHHC family of protein acyl transferases catalyzes palmitoylation of numerous proteins. The role of ZDHHC enzymes in intact tissue and in vivo is largely unknown. Herein, we characterize vascular functions in a mouse that expresses a nonfunctional ZDHHC21 (F233Δ). Approach and Results— Physiological studies of isolated aortae and mesenteric arteries from F233Δ mice revealed an unexpected defect in responsiveness to phenylephrine, an α1 adrenergic receptor agonist. In vivo, F233Δ mice displayed a blunted response to infusion of phenylephrine, and they were found to have elevated catecholamine levels and elevated vascular α1 adrenergic receptor gene expression. Telemetry studies showed that the F233Δ mice were tachycardic and hypotensive at baseline, consistent with diminished vascular tone. In biochemical studies, ZDHHC21 was shown to palmitoylate the α1D adrenoceptor and to interact with it in a molecular complex, thus suggesting a possible molecular mechanism by which the receptor can be regulated by ZDHHC21. Conclusions— Together, the data support a model in which ZDHHC21 F233Δ diminishes the function of vascular α1 adrenergic receptors, leading to reduced vascular tone, which manifests in vivo as hypotension and tachycardia. This is to our knowledge the first demonstration of a ZDHHC isoform affecting vascular function in vivo and identifies a novel molecular mode of regulation of vascular tone and blood pressure." @default.
• W2199173863 created "2016-06-24" @default.
• W2199173863 creator A5021638873 @default.
• W2199173863 creator A5023248825 @default.
• W2199173863 creator A5053543166 @default.
• W2199173863 creator A5053944497 @default.
• W2199173863 creator A5065994871 @default.
• W2199173863 creator A5067669342 @default.
• W2199173863 creator A5081685809 @default.
• W2199173863 creator A5082807034 @default.
• W2199173863 creator A5086341563 @default.
• W2199173863 date "2016-02-01" @default.
• W2199173863 modified "2023-10-18" @default.
• W2199173863 title "The Protein Acyl Transferase ZDHHC21 Modulates α1 Adrenergic Receptor Function and Regulates Hemodynamics" @default.
• W2199173863 cites W1159211040 @default.
• W2199173863 cites W1838021531 @default.
• W2199173863 cites W1974374321 @default.
• W2199173863 cites W1979746078 @default.
• W2199173863 cites W1981625060 @default.
• W2199173863 cites W1989996182 @default.
• W2199173863 cites W1991361029 @default.
• W2199173863 cites W1996712217 @default.
• W2199173863 cites W1998917031 @default.
• W2199173863 cites W2005576024 @default.
• W2199173863 cites W2009079516 @default.
• W2199173863 cites W2012395579 @default.
• W2199173863 cites W2017294957 @default.
• W2199173863 cites W2025673519 @default.
• W2199173863 cites W2027675867 @default.
• W2199173863 cites W2029954557 @default.
• W2199173863 cites W2031375592 @default.
• W2199173863 cites W2034512365 @default.
• W2199173863 cites W2045164997 @default.
• W2199173863 cites W2045216160 @default.
• W2199173863 cites W2046912635 @default.
• W2199173863 cites W2050419119 @default.
• W2199173863 cites W2051808752 @default.
• W2199173863 cites W2055965228 @default.
• W2199173863 cites W2057168970 @default.
• W2199173863 cites W2068034774 @default.
• W2199173863 cites W2071686994 @default.
• W2199173863 cites W2075514757 @default.
• W2199173863 cites W2077606276 @default.
• W2199173863 cites W2078410070 @default.
• W2199173863 cites W2087354432 @default.
• W2199173863 cites W2087780172 @default.
• W2199173863 cites W2089178885 @default.
• W2199173863 cites W2091193879 @default.
• W2199173863 cites W2091394988 @default.
• W2199173863 cites W2093139150 @default.
• W2199173863 cites W2095914409 @default.
• W2199173863 cites W2097428556 @default.
• W2199173863 cites W2099647122 @default.
• W2199173863 cites W2118972598 @default.
• W2199173863 cites W2119956579 @default.
• W2199173863 cites W2123294439 @default.
• W2199173863 cites W2129096803 @default.
• W2199173863 cites W2148864136 @default.
• W2199173863 cites W2149258280 @default.
• W2199173863 cites W2150601291 @default.
• W2199173863 cites W2152508553 @default.
• W2199173863 cites W2155055420 @default.
• W2199173863 cites W2155291851 @default.
• W2199173863 cites W2161079001 @default.
• W2199173863 cites W2164102845 @default.
• W2199173863 cites W2171494192 @default.
• W2199173863 cites W4243308053 @default.
• W2199173863 doi "https://doi.org/10.1161/atvbaha.115.306942" @default.
• W2199173863 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4984414" @default.
• W2199173863 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26715683" @default.
• W2199173863 hasPublicationYear "2016" @default.
• W2199173863 type Work @default.
• W2199173863 sameAs 2199173863 @default.
• W2199173863 citedByCount "17" @default.
• W2199173863 countsByYear W21991738632016 @default.
• W2199173863 countsByYear W21991738632018 @default.
• W2199173863 countsByYear W21991738632020 @default.
• W2199173863 countsByYear W21991738632021 @default.
• W2199173863 countsByYear W21991738632022 @default.
• W2199173863 countsByYear W21991738632023 @default.
• W2199173863 crossrefType "journal-article" @default.
• W2199173863 hasAuthorship W2199173863A5021638873 @default.
• W2199173863 hasAuthorship W2199173863A5023248825 @default.
• W2199173863 hasAuthorship W2199173863A5053543166 @default.
• W2199173863 hasAuthorship W2199173863A5053944497 @default.
• W2199173863 hasAuthorship W2199173863A5065994871 @default.
• W2199173863 hasAuthorship W2199173863A5067669342 @default.
• W2199173863 hasAuthorship W2199173863A5081685809 @default.
• W2199173863 hasAuthorship W2199173863A5082807034 @default.
• W2199173863 hasAuthorship W2199173863A5086341563 @default.
• W2199173863 hasBestOaLocation W21991738631 @default.
• W2199173863 hasConcept C126322002 @default.
• W2199173863 hasConcept C134018914 @default.
• W2199173863 hasConcept C146727910 @default.
• W2199173863 hasConcept C150903083 @default.
• W2199173863 hasConcept C158453852 @default.
• W2199173863 hasConcept C170493617 @default.
• W2199173863 hasConcept C181199279 @default.

• next