FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2199263774> ?p ?o ?g. }

• W2199263774 endingPage "23319" @default.
• W2199263774 startingPage "23310" @default.
• W2199263774 abstract "Here we report a target-catalyzed DNA four-way junction (DNA-4WJ) on the basis of toehold-mediated DNA strand displacement reaction (TM-SDR), which is readily applied in enzyme-free amplified chemiluminescence resonance energy transfer (CRET) imaging of microRNA. In this system, the introduction of target microRNA-let-7a (miR-let-7a) activates a cascade of assembly steps with four DNA hairpins, followed by a disassembly step in which the target microRNA is displaced and released from DNA-4WJ to catalyze the self-assembly of additional branched junctions. As a result, G-quadruplex subunit sequences and fluorophore fluorescein amidite (FAM) are encoded in DNA-4WJ in a close proximity, stimulating a CRET process in the presence of hemin/K+ to form horseradish peroxidase (HRP)-mimicking DNAzyme that catalyzes the generation of luminol/H2O2 chemiluminescence (CL), which further transfers to FAM. The background signal is easily reduced using magnetic graphene oxide (MGO) to remove unreacted species through magnetic separation, which makes a great contribution to improve the detection sensitivity and achieves a detection limit as low as 6.9 fM microRNA-let-7a (miR-let-7a). In addition, four-input concatenated logic circuits with an automatic reset function have been successfully constructed relying on the architecture of the proposed DNA-4WJ. More importantly, DNA nanohydrogels are self-assembled using DNA-4WJs as building units after centrifugation, which are driven by liquid crystallization and dense packaging of building units. Moreover, the DNA nanohydrogels are readily functionalized by incorporating with aptamers, bioimaging agents, and drug loading sites, which thus are served as efficient nanocarriers for targeted drug delivery and cancer therapy with high loading capacity and excellent biocompatibility." @default.
• W2199263774 created "2016-06-24" @default.
• W2199263774 creator A5005951490 @default.
• W2199263774 creator A5062750065 @default.
• W2199263774 creator A5079634357 @default.
• W2199263774 creator A5085479406 @default.
• W2199263774 date "2015-10-09" @default.
• W2199263774 modified "2023-10-17" @default.
• W2199263774 title "Target-Catalyzed DNA Four-Way Junctions for CRET Imaging of MicroRNA, Concatenated Logic Operations, and Self-Assembly of DNA Nanohydrogels for Targeted Drug Delivery" @default.
• W2199263774 cites W1774512411 @default.
• W2199263774 cites W1806374299 @default.
• W2199263774 cites W1829978875 @default.
• W2199263774 cites W1973528774 @default.
• W2199263774 cites W1983971366 @default.
• W2199263774 cites W1998547532 @default.
• W2199263774 cites W2004316626 @default.
• W2199263774 cites W2018924940 @default.
• W2199263774 cites W2021683440 @default.
• W2199263774 cites W2039288218 @default.
• W2199263774 cites W2053235652 @default.
• W2199263774 cites W2061567757 @default.
• W2199263774 cites W2066649475 @default.
• W2199263774 cites W2066661864 @default.
• W2199263774 cites W2092528383 @default.
• W2199263774 cites W2093863716 @default.
• W2199263774 cites W2094844506 @default.
• W2199263774 cites W2098263168 @default.
• W2199263774 cites W2102699655 @default.
• W2199263774 cites W2108013644 @default.
• W2199263774 cites W2115568341 @default.
• W2199263774 cites W2122240189 @default.
• W2199263774 cites W2131886674 @default.
• W2199263774 cites W2135417735 @default.
• W2199263774 cites W2140532084 @default.
• W2199263774 cites W2148304424 @default.
• W2199263774 cites W2154459955 @default.
• W2199263774 cites W2157337481 @default.
• W2199263774 cites W2168199960 @default.
• W2199263774 cites W2169120163 @default.
• W2199263774 cites W2169310432 @default.
• W2199263774 cites W230874093 @default.
• W2199263774 cites W2314455132 @default.
• W2199263774 cites W2315138333 @default.
• W2199263774 cites W2320441505 @default.
• W2199263774 cites W2322917738 @default.
• W2199263774 cites W2325331248 @default.
• W2199263774 cites W2327851543 @default.
• W2199263774 cites W4243768052 @default.
• W2199263774 doi "https://doi.org/10.1021/acsami.5b07827" @default.
• W2199263774 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26420675" @default.
• W2199263774 hasPublicationYear "2015" @default.
• W2199263774 type Work @default.
• W2199263774 sameAs 2199263774 @default.
• W2199263774 citedByCount "63" @default.
• W2199263774 countsByYear W21992637742016 @default.
• W2199263774 countsByYear W21992637742017 @default.
• W2199263774 countsByYear W21992637742018 @default.
• W2199263774 countsByYear W21992637742019 @default.
• W2199263774 countsByYear W21992637742020 @default.
• W2199263774 countsByYear W21992637742021 @default.
• W2199263774 countsByYear W21992637742022 @default.
• W2199263774 countsByYear W21992637742023 @default.
• W2199263774 crossrefType "journal-article" @default.
• W2199263774 hasAuthorship W2199263774A5005951490 @default.
• W2199263774 hasAuthorship W2199263774A5062750065 @default.
• W2199263774 hasAuthorship W2199263774A5079634357 @default.
• W2199263774 hasAuthorship W2199263774A5085479406 @default.
• W2199263774 hasConcept C121332964 @default.
• W2199263774 hasConcept C12554922 @default.
• W2199263774 hasConcept C129275984 @default.
• W2199263774 hasConcept C171250308 @default.
• W2199263774 hasConcept C181199279 @default.
• W2199263774 hasConcept C185592680 @default.
• W2199263774 hasConcept C192562407 @default.
• W2199263774 hasConcept C21951064 @default.
• W2199263774 hasConcept C2777676563 @default.
• W2199263774 hasConcept C552990157 @default.
• W2199263774 hasConcept C55493867 @default.
• W2199263774 hasConcept C62520636 @default.
• W2199263774 hasConcept C84211826 @default.
• W2199263774 hasConcept C86803240 @default.
• W2199263774 hasConcept C91881484 @default.
• W2199263774 hasConcept C96305047 @default.
• W2199263774 hasConceptScore W2199263774C121332964 @default.
• W2199263774 hasConceptScore W2199263774C12554922 @default.
• W2199263774 hasConceptScore W2199263774C129275984 @default.
• W2199263774 hasConceptScore W2199263774C171250308 @default.
• W2199263774 hasConceptScore W2199263774C181199279 @default.
• W2199263774 hasConceptScore W2199263774C185592680 @default.
• W2199263774 hasConceptScore W2199263774C192562407 @default.
• W2199263774 hasConceptScore W2199263774C21951064 @default.
• W2199263774 hasConceptScore W2199263774C2777676563 @default.
• W2199263774 hasConceptScore W2199263774C552990157 @default.
• W2199263774 hasConceptScore W2199263774C55493867 @default.
• W2199263774 hasConceptScore W2199263774C62520636 @default.
• W2199263774 hasConceptScore W2199263774C84211826 @default.
• W2199263774 hasConceptScore W2199263774C86803240 @default.
• W2199263774 hasConceptScore W2199263774C91881484 @default.

• next