Matches in SemOpenAlex for { <https://semopenalex.org/work/W2199524936> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2199524936 endingPage "134" @default.
- W2199524936 startingPage "123" @default.
- W2199524936 abstract "In an accurately determined X-ray diffraction study of the thyroid hormone thyroxine (T4), the two independent conformations in the crystal lattice show significant differences in the outer phenyl ring geometry when compared with that of 3,5,3'-triiodothyronine (T3). The major differences between the T4 and T3 structures are a shortened C4'-O4' bond, contraction of the C3'-C4'-C5' angle and an increase in the C3' and C5' angles of T4. These changes can be correlated with the difference in acidity of the 4'-OH of T4 and T3 and help to explain binding affinity differences among thyroactive compounds. The hydrogen bond directionality observed in T4 and other thyroid structures offers an insight into the molecular details of the hormone-receptor site. The conformation of one T4 molecule is cisoid, that of the other transoid, the first such instance of different overall conformations to be found in the same crystal lattice. One T4 molecule has the side chain nearly coplanar with the inner ring, an unusual conformation among thyroid structures." @default.
- W2199524936 created "2016-06-24" @default.
- W2199524936 creator A5088782676 @default.
- W2199524936 date "1979-01-01" @default.
- W2199524936 modified "2023-10-17" @default.
- W2199524936 title "Molecular Conformation of Thyroid Hormones: Structure and Binding Interactions of Thyroxine" @default.
- W2199524936 cites W1561580790 @default.
- W2199524936 cites W1573434238 @default.
- W2199524936 cites W2003492423 @default.
- W2199524936 cites W2033647778 @default.
- W2199524936 cites W2043141755 @default.
- W2199524936 cites W2062992896 @default.
- W2199524936 cites W2077904997 @default.
- W2199524936 cites W2129335319 @default.
- W2199524936 cites W2321678990 @default.
- W2199524936 doi "https://doi.org/10.1080/07435807909061100" @default.
- W2199524936 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/510217" @default.
- W2199524936 hasPublicationYear "1979" @default.
- W2199524936 type Work @default.
- W2199524936 sameAs 2199524936 @default.
- W2199524936 citedByCount "4" @default.
- W2199524936 countsByYear W21995249362017 @default.
- W2199524936 countsByYear W21995249362020 @default.
- W2199524936 crossrefType "journal-article" @default.
- W2199524936 hasAuthorship W2199524936A5088782676 @default.
- W2199524936 hasConcept C112887158 @default.
- W2199524936 hasConcept C115624301 @default.
- W2199524936 hasConcept C134018914 @default.
- W2199524936 hasConcept C178790620 @default.
- W2199524936 hasConcept C185592680 @default.
- W2199524936 hasConcept C193547582 @default.
- W2199524936 hasConcept C2778288131 @default.
- W2199524936 hasConcept C2779571634 @default.
- W2199524936 hasConcept C2780378348 @default.
- W2199524936 hasConcept C32909587 @default.
- W2199524936 hasConcept C526584372 @default.
- W2199524936 hasConcept C55493867 @default.
- W2199524936 hasConcept C71240020 @default.
- W2199524936 hasConcept C71315377 @default.
- W2199524936 hasConcept C8010536 @default.
- W2199524936 hasConcept C86803240 @default.
- W2199524936 hasConceptScore W2199524936C112887158 @default.
- W2199524936 hasConceptScore W2199524936C115624301 @default.
- W2199524936 hasConceptScore W2199524936C134018914 @default.
- W2199524936 hasConceptScore W2199524936C178790620 @default.
- W2199524936 hasConceptScore W2199524936C185592680 @default.
- W2199524936 hasConceptScore W2199524936C193547582 @default.
- W2199524936 hasConceptScore W2199524936C2778288131 @default.
- W2199524936 hasConceptScore W2199524936C2779571634 @default.
- W2199524936 hasConceptScore W2199524936C2780378348 @default.
- W2199524936 hasConceptScore W2199524936C32909587 @default.
- W2199524936 hasConceptScore W2199524936C526584372 @default.
- W2199524936 hasConceptScore W2199524936C55493867 @default.
- W2199524936 hasConceptScore W2199524936C71240020 @default.
- W2199524936 hasConceptScore W2199524936C71315377 @default.
- W2199524936 hasConceptScore W2199524936C8010536 @default.
- W2199524936 hasConceptScore W2199524936C86803240 @default.
- W2199524936 hasIssue "2" @default.
- W2199524936 hasLocation W21995249361 @default.
- W2199524936 hasLocation W21995249362 @default.
- W2199524936 hasOpenAccess W2199524936 @default.
- W2199524936 hasPrimaryLocation W21995249361 @default.
- W2199524936 hasRelatedWork W1972899349 @default.
- W2199524936 hasRelatedWork W2014324318 @default.
- W2199524936 hasRelatedWork W2063401985 @default.
- W2199524936 hasRelatedWork W2071073987 @default.
- W2199524936 hasRelatedWork W2420782624 @default.
- W2199524936 hasRelatedWork W2504212939 @default.
- W2199524936 hasRelatedWork W2557472534 @default.
- W2199524936 hasRelatedWork W2767205953 @default.
- W2199524936 hasRelatedWork W2788975530 @default.
- W2199524936 hasRelatedWork W646380683 @default.
- W2199524936 hasVolume "6" @default.
- W2199524936 isParatext "false" @default.
- W2199524936 isRetracted "false" @default.
- W2199524936 magId "2199524936" @default.
- W2199524936 workType "article" @default.