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- W2199569371 abstract "Hepatitis C virus (HCV) is the major cause of transfusion-associated hepatitis and accounts for a significant proportion of hepatitis cases worldwide. Most, if not all, infections become persistent and about 60% of cases develop chronic liver disease with various outcomes ranging from an asymptomatic carrier state to chronic active hepatitis and liver cirrhosis, which is strongly associated with the development of hepatocellular carcinoma. Since the initial cloning of the viral genome in 1989, our knowledge of the molecular biology of HCV has increased rapidly and led to the identification of several potential targets for antiviral intervention. In contrast, the low replication of the virus in cell culture, the lack of convenient animal models and the high genome variability present major challenges for drug development. This review will describe candidate drug targets and summarize ‘classical’ and ‘novel’ approaches currently being pursued to develop efficient HCV-specific therapies." @default.
- W2199569371 created "2016-06-24" @default.
- W2199569371 creator A5015740141 @default.
- W2199569371 date "1997-08-01" @default.
- W2199569371 modified "2023-10-03" @default.
- W2199569371 title "Molecular Targets in Inhibition of Hepatitis C Virus Replication" @default.
- W2199569371 cites W1506258653 @default.
- W2199569371 cites W1524967393 @default.
- W2199569371 cites W1530421800 @default.
- W2199569371 cites W1531200550 @default.
- W2199569371 cites W1538074723 @default.
- W2199569371 cites W1543166608 @default.
- W2199569371 cites W1548411824 @default.
- W2199569371 cites W1559621613 @default.
- W2199569371 cites W1564935170 @default.
- W2199569371 cites W1574175588 @default.
- W2199569371 cites W1574715597 @default.
- W2199569371 cites W1580329779 @default.
- W2199569371 cites W1582561043 @default.
- W2199569371 cites W1595507615 @default.
- W2199569371 cites W1612448259 @default.
- W2199569371 cites W1620465551 @default.
- W2199569371 cites W1622437624 @default.
- W2199569371 cites W1635062911 @default.
- W2199569371 cites W1647141819 @default.
- W2199569371 cites W1652147248 @default.
- W2199569371 cites W1656291587 @default.
- W2199569371 cites W1657824585 @default.
- W2199569371 cites W1673662691 @default.
- W2199569371 cites W1673857160 @default.
- W2199569371 cites W1762448935 @default.
- W2199569371 cites W1776345984 @default.
- W2199569371 cites W1820552472 @default.
- W2199569371 cites W1824353359 @default.
- W2199569371 cites W1836032532 @default.
- W2199569371 cites W1847011379 @default.
- W2199569371 cites W1877659824 @default.
- W2199569371 cites W1896010868 @default.
- W2199569371 cites W1914838920 @default.
- W2199569371 cites W1914884504 @default.
- W2199569371 cites W1914939604 @default.
- W2199569371 cites W1926962086 @default.
- W2199569371 cites W1928472258 @default.
- W2199569371 cites W1929220997 @default.
- W2199569371 cites W1950162085 @default.
- W2199569371 cites W1956249391 @default.
- W2199569371 cites W1957867949 @default.
- W2199569371 cites W1963636589 @default.
- W2199569371 cites W1964993943 @default.
- W2199569371 cites W1965642201 @default.
- W2199569371 cites W1971368161 @default.
- W2199569371 cites W1971475307 @default.
- W2199569371 cites W1971597849 @default.
- W2199569371 cites W1971792395 @default.
- W2199569371 cites W1971800756 @default.
- W2199569371 cites W1972846278 @default.
- W2199569371 cites W1973165481 @default.
- W2199569371 cites W1974238871 @default.
- W2199569371 cites W1974655988 @default.
- W2199569371 cites W1974879228 @default.
- W2199569371 cites W1975423158 @default.
- W2199569371 cites W1976707255 @default.
- W2199569371 cites W1979919755 @default.
- W2199569371 cites W1981063326 @default.
- W2199569371 cites W1981326731 @default.
- W2199569371 cites W1982302584 @default.
- W2199569371 cites W1982957818 @default.
- W2199569371 cites W1983149942 @default.
- W2199569371 cites W1985694728 @default.
- W2199569371 cites W1985882441 @default.
- W2199569371 cites W1986077941 @default.
- W2199569371 cites W1989062065 @default.
- W2199569371 cites W1990333416 @default.
- W2199569371 cites W1990884146 @default.
- W2199569371 cites W1991352994 @default.
- W2199569371 cites W1995634184 @default.
- W2199569371 cites W1995678223 @default.
- W2199569371 cites W1996453956 @default.
- W2199569371 cites W2001241073 @default.
- W2199569371 cites W2001945066 @default.
- W2199569371 cites W2006251590 @default.
- W2199569371 cites W2006309458 @default.
- W2199569371 cites W2008954911 @default.
- W2199569371 cites W2009581957 @default.
- W2199569371 cites W2014127609 @default.
- W2199569371 cites W2016245502 @default.
- W2199569371 cites W2017874433 @default.
- W2199569371 cites W2019655344 @default.
- W2199569371 cites W2021108691 @default.
- W2199569371 cites W2022013776 @default.
- W2199569371 cites W2022965184 @default.
- W2199569371 cites W2023365135 @default.
- W2199569371 cites W2026133647 @default.
- W2199569371 cites W2027598863 @default.
- W2199569371 cites W2028365005 @default.
- W2199569371 cites W2028843900 @default.
- W2199569371 cites W2029111090 @default.
- W2199569371 cites W2029176233 @default.