Matches in SemOpenAlex for { <https://semopenalex.org/work/W2199708805> ?p ?o ?g. }
- W2199708805 endingPage "1513" @default.
- W2199708805 startingPage "1511" @default.
- W2199708805 abstract "Enantiomerically pure chiral amines are ubiquitous chemical building blocks in bioactive pharmaceutical products and their synthesis from simple starting materials is of great interest. One of the most attractive strategies is the stereoselective installation of a chiral amine through C-H amination, which is a challenging chemical transformation. Herein we report the application of a multienzyme cascade, generated in a single bacterial whole-cell system, which is able to catalyze stereoselective benzylic aminations with ee values of 97.5%. The cascade uses four heterologously expressed recombinant enzymes with cofactors provided by the host cell and isopropyl amine added as the amine donor. The cascade presents the first example of the successful de novo design of a single whole-cell biocatalyst for formal stereoselective C-H amination." @default.
- W2199708805 created "2016-06-24" @default.
- W2199708805 creator A5018621965 @default.
- W2199708805 creator A5063051779 @default.
- W2199708805 creator A5067959288 @default.
- W2199708805 creator A5072616467 @default.
- W2199708805 creator A5073735499 @default.
- W2199708805 creator A5090072935 @default.
- W2199708805 date "2015-12-21" @default.
- W2199708805 modified "2023-10-03" @default.
- W2199708805 title "Whole-Cell Biocatalysts for Stereoselective C−H Amination Reactions" @default.
- W2199708805 cites W1902645650 @default.
- W2199708805 cites W1984977604 @default.
- W2199708805 cites W1995612596 @default.
- W2199708805 cites W1997518275 @default.
- W2199708805 cites W2018843701 @default.
- W2199708805 cites W2027583385 @default.
- W2199708805 cites W2041553704 @default.
- W2199708805 cites W2051170144 @default.
- W2199708805 cites W2069544596 @default.
- W2199708805 cites W2077437218 @default.
- W2199708805 cites W2080967263 @default.
- W2199708805 cites W2083524668 @default.
- W2199708805 cites W2093518771 @default.
- W2199708805 cites W2094303759 @default.
- W2199708805 cites W2123321938 @default.
- W2199708805 cites W2125859860 @default.
- W2199708805 cites W2129795349 @default.
- W2199708805 cites W2133621392 @default.
- W2199708805 cites W2135551767 @default.
- W2199708805 cites W2161278159 @default.
- W2199708805 cites W2167083461 @default.
- W2199708805 cites W2167149302 @default.
- W2199708805 cites W2249971244 @default.
- W2199708805 cites W2266239956 @default.
- W2199708805 cites W2321271242 @default.
- W2199708805 cites W2411848501 @default.
- W2199708805 cites W4213136489 @default.
- W2199708805 cites W4232842950 @default.
- W2199708805 cites W4234557919 @default.
- W2199708805 cites W4245327166 @default.
- W2199708805 cites W4248515401 @default.
- W2199708805 doi "https://doi.org/10.1002/anie.201510028" @default.
- W2199708805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26689856" @default.
- W2199708805 hasPublicationYear "2015" @default.
- W2199708805 type Work @default.
- W2199708805 sameAs 2199708805 @default.
- W2199708805 citedByCount "83" @default.
- W2199708805 countsByYear W21997088052016 @default.
- W2199708805 countsByYear W21997088052017 @default.
- W2199708805 countsByYear W21997088052018 @default.
- W2199708805 countsByYear W21997088052019 @default.
- W2199708805 countsByYear W21997088052020 @default.
- W2199708805 countsByYear W21997088052021 @default.
- W2199708805 countsByYear W21997088052022 @default.
- W2199708805 countsByYear W21997088052023 @default.
- W2199708805 crossrefType "journal-article" @default.
- W2199708805 hasAuthorship W2199708805A5018621965 @default.
- W2199708805 hasAuthorship W2199708805A5063051779 @default.
- W2199708805 hasAuthorship W2199708805A5067959288 @default.
- W2199708805 hasAuthorship W2199708805A5072616467 @default.
- W2199708805 hasAuthorship W2199708805A5073735499 @default.
- W2199708805 hasAuthorship W2199708805A5090072935 @default.
- W2199708805 hasConcept C104264131 @default.
- W2199708805 hasConcept C131779359 @default.
- W2199708805 hasConcept C161790260 @default.
- W2199708805 hasConcept C178790620 @default.
- W2199708805 hasConcept C181647583 @default.
- W2199708805 hasConcept C185592680 @default.
- W2199708805 hasConcept C191503008 @default.
- W2199708805 hasConcept C198503264 @default.
- W2199708805 hasConcept C21951064 @default.
- W2199708805 hasConcept C2779938440 @default.
- W2199708805 hasConcept C65024703 @default.
- W2199708805 hasConcept C71240020 @default.
- W2199708805 hasConceptScore W2199708805C104264131 @default.
- W2199708805 hasConceptScore W2199708805C131779359 @default.
- W2199708805 hasConceptScore W2199708805C161790260 @default.
- W2199708805 hasConceptScore W2199708805C178790620 @default.
- W2199708805 hasConceptScore W2199708805C181647583 @default.
- W2199708805 hasConceptScore W2199708805C185592680 @default.
- W2199708805 hasConceptScore W2199708805C191503008 @default.
- W2199708805 hasConceptScore W2199708805C198503264 @default.
- W2199708805 hasConceptScore W2199708805C21951064 @default.
- W2199708805 hasConceptScore W2199708805C2779938440 @default.
- W2199708805 hasConceptScore W2199708805C65024703 @default.
- W2199708805 hasConceptScore W2199708805C71240020 @default.
- W2199708805 hasFunder F4320320006 @default.
- W2199708805 hasFunder F4320320300 @default.
- W2199708805 hasIssue "4" @default.
- W2199708805 hasLocation W21997088051 @default.
- W2199708805 hasLocation W21997088052 @default.
- W2199708805 hasOpenAccess W2199708805 @default.
- W2199708805 hasPrimaryLocation W21997088051 @default.
- W2199708805 hasRelatedWork W1564546943 @default.
- W2199708805 hasRelatedWork W1974709238 @default.
- W2199708805 hasRelatedWork W2021492309 @default.
- W2199708805 hasRelatedWork W2199708805 @default.