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- W2199769752 abstract "breast cancer” (estrogen/progesterone receptor status) from the 2006 publication of Ma et al. a meta-analysis of reproductive factors and breast cancer risk [1] would argue otherwise. In a number of studies, early menarche has been identified as an important risk factor for breast cancer which has been explained by increased hormonal exposure. But among monozygotic twins, this risk becomes much stronger, implicating genetic factors as well [2]. The focus of recent female cancer epidemiological study designs has shifted from adult cohort studies to the ontogeny of female reproductive organs [2–5], presenting potential causal data either leading to or resulting from precocious puberty, late versus early breast development, parity and age at first birth. In a recent microarray gene expression study we found a group of related genes known to regulate the cell cycle and suppression of tumor growth (termed tumor related genes or TRGs) to be one of the most prominent groups of genes to increase hypothalamic expression throughout female puberty [6]. When the above factors are considered within the context of the newly unveiled hypothalamic polygenic TRG network, compelling research questions" @default.
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- W2199769752 date "2008-01-01" @default.
- W2199769752 modified "2023-09-23" @default.
- W2199769752 title "Early Puberty Onset and Female Cancers—Is There a Link?" @default.
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