FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2199795619> ?p ?o ?g. }

• W2199795619 endingPage "7" @default.
• W2199795619 startingPage "3" @default.
• W2199795619 abstract "The possibility that inflammatory processes in the brain contribute to the etiopathogenesis of seizures and the establishment of a chronic epileptic focus is increasingly recognized as a result of supportive evidence in experimental models and in the clinical setting. Prototypical inflammatory cytokines (such as IL-1beta) and danger signals (such as HMGB1 and S100beta) are overexpressed in human and experimental epileptogenic tissue, prominently by glia. Neurons and endothelial cells of the blood-brain barrier contribute to inflammatory processes. All these cell types also express receptors for inflammatory mediators, suggesting that inflammatory molecules in the brain exert both autocrine and paracrine activation of intracellular signaling cascades; thus, they may act as soluble mediators of cell communication in diseased tissue. In experimental models, seizures also trigger brain inflammation in the absence of cell loss; in human epileptogenic tissue, the type of neuropathology associated with chronic seizures contributes to determine the type of cells expressing the inflammatory mediators, and the extent to which inflammation occurs. Inflammatory molecules, such as IL-1beta and HMGB1, have proconvulsant activity in various seizure models, most likely by decreasing seizure threshold via functional interactions with classical neurotransmitter systems. These findings reveal novel glioneuronal communications in epileptic tissue that highlight potential new targets for therapeutic intervention." @default.
• W2199795619 created "2016-06-24" @default.
• W2199795619 creator A5070101998 @default.
• W2199795619 date "2014-01-01" @default.
• W2199795619 modified "2023-10-17" @default.
• W2199795619 title "Epilepsy and Inflammation in the Brain: Overview and Pathophysiology" @default.
• W2199795619 cites W1482709215 @default.
• W2199795619 cites W1522823711 @default.
• W2199795619 cites W1555113073 @default.
• W2199795619 cites W1968420305 @default.
• W2199795619 cites W1970423904 @default.
• W2199795619 cites W1971775352 @default.
• W2199795619 cites W1974398884 @default.
• W2199795619 cites W1976582395 @default.
• W2199795619 cites W1977291679 @default.
• W2199795619 cites W1978525572 @default.
• W2199795619 cites W1979096652 @default.
• W2199795619 cites W1982558709 @default.
• W2199795619 cites W1985911926 @default.
• W2199795619 cites W1988802500 @default.
• W2199795619 cites W1990535528 @default.
• W2199795619 cites W1994627202 @default.
• W2199795619 cites W2003907850 @default.
• W2199795619 cites W2005101685 @default.
• W2199795619 cites W2022671065 @default.
• W2199795619 cites W2022796522 @default.
• W2199795619 cites W2022981588 @default.
• W2199795619 cites W2031855726 @default.
• W2199795619 cites W2033242795 @default.
• W2199795619 cites W2040793043 @default.
• W2199795619 cites W2040958998 @default.
• W2199795619 cites W2042393720 @default.
• W2199795619 cites W2049455313 @default.
• W2199795619 cites W2053111794 @default.
• W2199795619 cites W2073007581 @default.
• W2199795619 cites W2077178493 @default.
• W2199795619 cites W2078412655 @default.
• W2199795619 cites W2080742766 @default.
• W2199795619 cites W2081689918 @default.
• W2199795619 cites W2083881390 @default.
• W2199795619 cites W2087982685 @default.
• W2199795619 cites W2093093918 @default.
• W2199795619 cites W2097145372 @default.
• W2199795619 cites W2098569132 @default.
• W2199795619 cites W2100170919 @default.
• W2199795619 cites W2103046674 @default.
• W2199795619 cites W2108170307 @default.
• W2199795619 cites W2109590683 @default.
• W2199795619 cites W2110412659 @default.
• W2199795619 cites W2112937635 @default.
• W2199795619 cites W2120932443 @default.
• W2199795619 cites W2121260921 @default.
• W2199795619 cites W2127587930 @default.
• W2199795619 cites W2132680120 @default.
• W2199795619 cites W2135328571 @default.
• W2199795619 cites W2140790402 @default.
• W2199795619 cites W2141720672 @default.
• W2199795619 cites W2146768507 @default.
• W2199795619 cites W2148780480 @default.
• W2199795619 cites W2150047376 @default.
• W2199795619 cites W2154880023 @default.
• W2199795619 cites W2161456882 @default.
• W2199795619 cites W2167121498 @default.
• W2199795619 doi "https://doi.org/10.5698/1535-7511-14.s2.3" @default.
• W2199795619 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3966641" @default.
• W2199795619 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24955068" @default.
• W2199795619 hasPublicationYear "2014" @default.
• W2199795619 type Work @default.
• W2199795619 sameAs 2199795619 @default.
• W2199795619 citedByCount "145" @default.
• W2199795619 countsByYear W21997956192014 @default.
• W2199795619 countsByYear W21997956192015 @default.
• W2199795619 countsByYear W21997956192016 @default.
• W2199795619 countsByYear W21997956192017 @default.
• W2199795619 countsByYear W21997956192018 @default.
• W2199795619 countsByYear W21997956192019 @default.
• W2199795619 countsByYear W21997956192020 @default.
• W2199795619 countsByYear W21997956192021 @default.
• W2199795619 countsByYear W21997956192022 @default.
• W2199795619 countsByYear W21997956192023 @default.
• W2199795619 crossrefType "journal-article" @default.
• W2199795619 hasAuthorship W2199795619A5070101998 @default.
• W2199795619 hasBestOaLocation W21997956192 @default.
• W2199795619 hasConcept C10162356 @default.
• W2199795619 hasConcept C126322002 @default.
• W2199795619 hasConcept C128240485 @default.
• W2199795619 hasConcept C142724271 @default.
• W2199795619 hasConcept C1491633281 @default.
• W2199795619 hasConcept C169760540 @default.
• W2199795619 hasConcept C170493617 @default.
• W2199795619 hasConcept C189014844 @default.
• W2199795619 hasConcept C203014093 @default.
• W2199795619 hasConcept C2776914184 @default.
• W2199795619 hasConcept C2778186239 @default.
• W2199795619 hasConcept C2779134260 @default.
• W2199795619 hasConcept C2780130745 @default.
• W2199795619 hasConcept C2780545709 @default.
• W2199795619 hasConcept C54355233 @default.

• next