Matches in SemOpenAlex for { <https://semopenalex.org/work/W2200539970> ?p ?o ?g. }
- W2200539970 endingPage "1411" @default.
- W2200539970 startingPage "1400" @default.
- W2200539970 abstract "Generating kidney organoids using human stem cells could offer promising prospects for research and therapeutic purposes. However, no cell-based strategy has generated nephrons displaying an intact three-dimensional epithelial filtering barrier. Here, we generated organoids using murine embryonic kidney cells, and documented that these tissues recapitulated the complex three-dimensional filtering structure of glomerular slits in vivo and accomplished selective glomerular filtration and tubular reabsorption. Exploiting this technology, we mixed human amniotic fluid stem cells with mouse embryonic kidney cells to establish three-dimensional chimeric organoids that engrafted in vivo and grew to form vascularized glomeruli and tubular structures. Human cells contributed to the formation of glomerular structures, differentiated into podocytes with slit diaphragms, and internalized exogenously infused BSA, thus attaining in vivo degrees of specialization and function unprecedented for donor stem cells. In conclusion, human amniotic fluid stem cell chimeric organoids may offer new paths for studying renal development and human podocyte disease, and for facilitating drug discovery and translational research." @default.
- W2200539970 created "2016-06-24" @default.
- W2200539970 creator A5004848162 @default.
- W2200539970 creator A5007893696 @default.
- W2200539970 creator A5015538475 @default.
- W2200539970 creator A5020474537 @default.
- W2200539970 creator A5023556434 @default.
- W2200539970 creator A5033003059 @default.
- W2200539970 creator A5035442609 @default.
- W2200539970 creator A5048185523 @default.
- W2200539970 creator A5054640225 @default.
- W2200539970 creator A5071305673 @default.
- W2200539970 creator A5073398411 @default.
- W2200539970 creator A5075056969 @default.
- W2200539970 creator A5078814791 @default.
- W2200539970 creator A5090115261 @default.
- W2200539970 date "2015-10-29" @default.
- W2200539970 modified "2023-10-14" @default.
- W2200539970 title "Functional Human Podocytes Generated in Organoids from Amniotic Fluid Stem Cells" @default.
- W2200539970 cites W1968002068 @default.
- W2200539970 cites W1968216888 @default.
- W2200539970 cites W1970339827 @default.
- W2200539970 cites W1975281925 @default.
- W2200539970 cites W1981012330 @default.
- W2200539970 cites W1989244336 @default.
- W2200539970 cites W2000657793 @default.
- W2200539970 cites W2000714884 @default.
- W2200539970 cites W2008926735 @default.
- W2200539970 cites W2017252528 @default.
- W2200539970 cites W2023115164 @default.
- W2200539970 cites W2029706942 @default.
- W2200539970 cites W2037801572 @default.
- W2200539970 cites W2044928246 @default.
- W2200539970 cites W2054225562 @default.
- W2200539970 cites W2073097828 @default.
- W2200539970 cites W2075695335 @default.
- W2200539970 cites W2091652646 @default.
- W2200539970 cites W2092292069 @default.
- W2200539970 cites W2092946806 @default.
- W2200539970 cites W2093529221 @default.
- W2200539970 cites W2094283653 @default.
- W2200539970 cites W2105250253 @default.
- W2200539970 cites W2111650261 @default.
- W2200539970 cites W2116228354 @default.
- W2200539970 cites W2126394082 @default.
- W2200539970 cites W2129416468 @default.
- W2200539970 cites W2137313377 @default.
- W2200539970 cites W2144695452 @default.
- W2200539970 cites W2144897740 @default.
- W2200539970 cites W2150699722 @default.
- W2200539970 cites W2152858552 @default.
- W2200539970 cites W2164755825 @default.
- W2200539970 cites W2165438231 @default.
- W2200539970 cites W2172053176 @default.
- W2200539970 cites W2181641521 @default.
- W2200539970 cites W2259302643 @default.
- W2200539970 cites W2316465341 @default.
- W2200539970 cites W2332798572 @default.
- W2200539970 cites W2338476068 @default.
- W2200539970 cites W2396916896 @default.
- W2200539970 cites W50679073 @default.
- W2200539970 doi "https://doi.org/10.1681/asn.2015030316" @default.
- W2200539970 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4849826" @default.
- W2200539970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26516208" @default.
- W2200539970 hasPublicationYear "2015" @default.
- W2200539970 type Work @default.
- W2200539970 sameAs 2200539970 @default.
- W2200539970 citedByCount "48" @default.
- W2200539970 countsByYear W22005399702015 @default.
- W2200539970 countsByYear W22005399702016 @default.
- W2200539970 countsByYear W22005399702017 @default.
- W2200539970 countsByYear W22005399702018 @default.
- W2200539970 countsByYear W22005399702019 @default.
- W2200539970 countsByYear W22005399702020 @default.
- W2200539970 countsByYear W22005399702021 @default.
- W2200539970 countsByYear W22005399702022 @default.
- W2200539970 countsByYear W22005399702023 @default.
- W2200539970 crossrefType "journal-article" @default.
- W2200539970 hasAuthorship W2200539970A5004848162 @default.
- W2200539970 hasAuthorship W2200539970A5007893696 @default.
- W2200539970 hasAuthorship W2200539970A5015538475 @default.
- W2200539970 hasAuthorship W2200539970A5020474537 @default.
- W2200539970 hasAuthorship W2200539970A5023556434 @default.
- W2200539970 hasAuthorship W2200539970A5033003059 @default.
- W2200539970 hasAuthorship W2200539970A5035442609 @default.
- W2200539970 hasAuthorship W2200539970A5048185523 @default.
- W2200539970 hasAuthorship W2200539970A5054640225 @default.
- W2200539970 hasAuthorship W2200539970A5071305673 @default.
- W2200539970 hasAuthorship W2200539970A5073398411 @default.
- W2200539970 hasAuthorship W2200539970A5075056969 @default.
- W2200539970 hasAuthorship W2200539970A5078814791 @default.
- W2200539970 hasAuthorship W2200539970A5090115261 @default.
- W2200539970 hasBestOaLocation W22005399701 @default.
- W2200539970 hasConcept C104317684 @default.
- W2200539970 hasConcept C109661977 @default.
- W2200539970 hasConcept C134018914 @default.
- W2200539970 hasConcept C138851942 @default.
- W2200539970 hasConcept C145103041 @default.